A Model of Bacterial Intestinal Infections in Drosophila melanogaster (2007)
Nadine T. Nehme, Samuel Liégeois, Beatrix Kele, Philippe Giammarinaro, Elizabeth Pradel, Jules A. Hoffmann, ...
Serratia marcescens is an entomopathogenic bacterium that opportunistically infects a wide range of hosts, including humans. In a model of septic injury, if directly introduced into the body cavity...
Shin-Hong Shiao, Daniel Zachary, Jules A. Hoffmann, Elena A. Levashina
The midgut epithelium of the mosquito malaria vector Anopheles is a hostile environment for Plasmodium, with most parasites succumbing to host defenses. This study addresses morphological and...
Vincent Bischoff, Cécile Vignal, Bernard Duvic, Ivo G. Boneca, Jules A. Hoffmann, Julien Royet
Peptidoglycan-recognition proteins (PGRPs) are evolutionarily conserved molecules that are structurally related to bacterial amidases. Several Drosophila PGRPs have lost this enzymatic activity and...
The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response
Basset, Alan, Khush, Ranjiv S., Braun, Anne, Gardan, Louis, Boccard, Frédéric, Hoffmann, Jules A., ...
Although Drosophila possesses potent immune responses, little is known about the microbial pathogens that infect Drosophila. We have identified members of the bacterial genus Erwinia that induce the...
Lagueux, Marie, Perrodou, Emmanuel, Levashina, Elena A., Capovilla, Maria, Hoffmann, Jules A.
We show that Drosophila expresses four genes encoding proteins with significant similarities with the thiolester-containing proteins of the complement C3/α2-macroglobulin superfamily. The genes are...
Uttenweiler-Joseph, Sandrine, Moniatte, Marc, Lagueux, Marie, Van Dorsselaer, Alain, Hoffmann, Jules A., Bulet, Philippe
We have developed an approach based on a differential mass spectrometric analysis to detect molecules induced during the immune response of Drosophila, regardless of their biological activities. For...
Analysis of the Drosophila host defense in domino mutant larvae, which are devoid of hemocytes
Braun, Anne, Hoffmann, Jules A., Meister, Marie
We have analyzed the Drosophila immune response in domino mutant larvae, which are devoid of blood cells. The domino mutants have a good larval viability, but they die as prepupae. We show that, on...
Lemaitre, Bruno, Reichhart, Jean-Marc, Hoffmann, Jules A.
Insects respond to microbial infection by the rapid and transient expression of several genes encoding potent antimicrobial peptides. Herein we demonstrate that this antimicrobial response of...
Toll-related receptors and the control of antimicrobial peptide expression in Drosophila
Tauszig, Servane, Jouanguy, Emmanuelle, Hoffmann, Jules A., Imler, Jean-Luc
Insects defend themselves against infectious microorganisms by synthesizing potent antimicrobial peptides. Drosophila has appeared in recent years as a favorable model to study this innate host...
Gambicin: A novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae
Vizioli, Jacopo, Bulet, Philippe, Hoffmann, Jules A., Kafatos, Fotis C., Müller, Hans-Michael, Dimopoulos, George
A novel mosquito antimicrobial peptide, gambicin, and the corresponding gene were isolated in parallel through differential display-PCR, an expressed sequence tag (EST) project, and characterization...
A genome-wide analysis of immune responses in Drosophila
Irving, Phil, Troxler, Laurent, Heuer, Timothy S., Belvin, Marcia, Kopczynski, Casey, Reichhart, Jean-Marc, ...
Oligonucleotide DNA microarrays were used for a genome-wide analysis of immune-challenged Drosophila infected with Gram-positive or Gram-negative bacteria, or with fungi. Aside from the expression of...
A serpin mutant links Toll activation to melanization in the host defence of Drosophila
Ligoxygakis, Petros, Pelte, Nadège, Ji, Chuanyi, Leclerc, Vincent, Duvic, Bernard, Belvin, Marcia, ...
A prominent response during the Drosophila host defence is the induction of proteolytic cascades, some of which lead to localized melanization of pathogen surfaces, while others activate one of the...
Kurz, C.Léopold, Chauvet, Sophie, Andrès, Emmanuel, Aurouze, Marianne, Vallet, Isabelle, Michel, Gérard P.F., ...
The human opportunistic pathogen Serratia marcescens is a bacterium with a broad host range, and represents a growing problem for public health. Serratia marcescens kills Caenorhabditis elegans after...
Costet, Marie F., El Achouri, Mostafa, Charlet, Maurice, Lanot, Rene, Benveniste, Pierre, Hoffmann, Jules A.
Wheat seedlings germinating in the presence of the systemic fungicide fenpropimorph accumulate 9β,19-cyclopropylsterols (95% of total sterols) in place of Δ5-sterols, which are normally produced in...
PVF2, a PDGF/VEGF-like growth factor, induces hemocyte proliferation in Drosophila larvae
Munier, Anne-Isabelle, Doucet, Daniel, Perrodou, Emmanuel, Zachary, Daniel, Meister, Marie, Hoffmann, Jules A., ...
Blood cells play a crucial role in both morphogenetic and immunological processes in Drosophila, yet the factors regulating their proliferation remain largely unknown. In order to address this...
Downregulation of the Drosophila Immune Response by Peptidoglycan-Recognition Proteins SC1 and SC2
Bischoff, Vincent, Vignal, Cécile, Duvic, Bernard, Boneca, Ivo G, Hoffmann, Jules A, Royet, Julien
Peptidoglycan-recognition proteins (PGRPs) are evolutionarily conserved molecules that are structurally related to bacterial amidases. Several Drosophila PGRPs have lost this enzymatic activity and...
The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response
Basset, Alan, Khush, Ranjiv S., Braun, Anne, Gardan, Louis, Boccard, Frédéric, Hoffmann, Jules A., ...
Although Drosophila possesses potent immune responses, little is known about the microbial pathogens that infect Drosophila. We have identified members of the bacterial genus Erwinia that induce the...
Lagueux, Marie, Perrodou, Emmanuel, Levashina, Elena A., Capovilla, Maria, Hoffmann, Jules A.
We show that Drosophila expresses four genes encoding proteins with significant similarities with the thiolester-containing proteins of the complement C3/α2-macroglobulin superfamily. The genes are...
Uttenweiler-Joseph, Sandrine, Moniatte, Marc, Lagueux, Marie, Van Dorsselaer, Alain, Hoffmann, Jules A., Bulet, Philippe
We have developed an approach based on a differential mass spectrometric analysis to detect molecules induced during the immune response of Drosophila, regardless of their biological activities. For...
Analysis of the Drosophila host defense in domino mutant larvae, which are devoid of hemocytes
Braun, Anne, Hoffmann, Jules A., Meister, Marie
We have analyzed the Drosophila immune response in domino mutant larvae, which are devoid of blood cells. The domino mutants have a good larval viability, but they die as prepupae. We show that, on...
Lemaitre, Bruno, Reichhart, Jean-Marc, Hoffmann, Jules A.
Insects respond to microbial infection by the rapid and transient expression of several genes encoding potent antimicrobial peptides. Herein we demonstrate that this antimicrobial response of...
Toll-related receptors and the control of antimicrobial peptide expression in Drosophila
Tauszig, Servane, Jouanguy, Emmanuelle, Hoffmann, Jules A., Imler, Jean-Luc
Insects defend themselves against infectious microorganisms by synthesizing potent antimicrobial peptides. Drosophila has appeared in recent years as a favorable model to study this innate host...
Gambicin: A novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae
Vizioli, Jacopo, Bulet, Philippe, Hoffmann, Jules A., Kafatos, Fotis C., Müller, Hans-Michael, Dimopoulos, George
A novel mosquito antimicrobial peptide, gambicin, and the corresponding gene were isolated in parallel through differential display-PCR, an expressed sequence tag (EST) project, and characterization...
A genome-wide analysis of immune responses in Drosophila
Irving, Phil, Troxler, Laurent, Heuer, Timothy S., Belvin, Marcia, Kopczynski, Casey, Reichhart, Jean-Marc, ...
Oligonucleotide DNA microarrays were used for a genome-wide analysis of immune-challenged Drosophila infected with Gram-positive or Gram-negative bacteria, or with fungi. Aside from the expression of...
A serpin mutant links Toll activation to melanization in the host defence of Drosophila
Ligoxygakis, Petros, Pelte, Nadège, Ji, Chuanyi, Leclerc, Vincent, Duvic, Bernard, Belvin, Marcia, ...
A prominent response during the Drosophila host defence is the induction of proteolytic cascades, some of which lead to localized melanization of pathogen surfaces, while others activate one of the...
Kurz, C.Léopold, Chauvet, Sophie, Andrès, Emmanuel, Aurouze, Marianne, Vallet, Isabelle, Michel, Gérard P.F., ...
The human opportunistic pathogen Serratia marcescens is a bacterium with a broad host range, and represents a growing problem for public health. Serratia marcescens kills Caenorhabditis elegans after...
Costet, Marie F., El Achouri, Mostafa, Charlet, Maurice, Lanot, Rene, Benveniste, Pierre, Hoffmann, Jules A.
Wheat seedlings germinating in the presence of the systemic fungicide fenpropimorph accumulate 9β,19-cyclopropylsterols (95% of total sterols) in place of Δ5-sterols, which are normally produced in...
PVF2, a PDGF/VEGF-like growth factor, induces hemocyte proliferation in Drosophila larvae
Munier, Anne-Isabelle, Doucet, Daniel, Perrodou, Emmanuel, Zachary, Daniel, Meister, Marie, Hoffmann, Jules A., ...
Blood cells play a crucial role in both morphogenetic and immunological processes in Drosophila, yet the factors regulating their proliferation remain largely unknown. In order to address this...
Downregulation of the Drosophila Immune Response by Peptidoglycan-Recognition Proteins SC1 and SC2
Bischoff, Vincent, Vignal, Cécile, Duvic, Bernard, Boneca, Ivo G, Hoffmann, Jules A, Royet, Julien
Peptidoglycan-recognition proteins (PGRPs) are evolutionarily conserved molecules that are structurally related to bacterial amidases. Several Drosophila PGRPs have lost this enzymatic activity and...
Shiao, Shin-Hong, Whitten, Miranda M. A, Zachary, Daniel, Hoffmann, Jules A, Levashina, Elena A
The midgut epithelium of the mosquito malaria vector Anopheles is a hostile environment for Plasmodium, with most parasites succumbing to host defenses. This study addresses morphological and...
Prophenoloxidase activation is not required for survival to microbial infections in Drosophila
Leclerc, Vincent, Pelte, Nadège, Chamy, Laure El, Martinelli, Cosimo, Ligoxygakis, Petros, Hoffmann, Jules A, ...
The antimicrobial defence of Drosophila relies on cellular and humoral processes, of which the inducible synthesis of antimicrobial peptides has attracted interest in recent years. Another potential...
A Model of Bacterial Intestinal Infections in Drosophila melanogaster
Nehme, Nadine T, Liégeois, Samuel, Kele, Beatrix, Giammarinaro, Philippe, Pradel, Elizabeth, Hoffmann, Jules A, ...
Serratia marcescens is an entomopathogenic bacterium that opportunistically infects a wide range of hosts, including humans. In a model of septic injury, if directly introduced into the body cavity...