Diss. -- Tampereen yliopisto.
ANX7, a candidate tumor suppressor gene for prostate cancer
Srivastava, Meera, Bubendorf, Lukas, Srikantan, Vasantha, Fossom, Linda, Nolan, Lisa, Glasman, Mirta, ...
The ANX7 gene is located on human chromosome 10q21, a site long hypothesized to harbor a tumor suppressor gene(s) (TSG) associated with prostate and other cancers. To test whether ANX7 might be a...
Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer
Monni, Outi, Bärlund, Maarit, Mousses, Spyro, Kononen, Juha, Sauter, Guido, Heiskanen, Mervi, ...
The biological significance of DNA amplification in cancer is thought to be due to the selection of increased expression of a single or few important genes. However, systematic surveys of the copy...
ANX7, a candidate tumor suppressor gene for prostate cancer
Srivastava, Meera, Bubendorf, Lukas, Srikantan, Vasantha, Fossom, Linda, Nolan, Lisa, Glasman, Mirta, ...
The ANX7 gene is located on human chromosome 10q21, a site long hypothesized to harbor a tumor suppressor gene(s) (TSG) associated with prostate and other cancers. To test whether ANX7 might be a...
Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer
Monni, Outi, Bärlund, Maarit, Mousses, Spyro, Kononen, Juha, Sauter, Guido, Heiskanen, Mervi, ...
The biological significance of DNA amplification in cancer is thought to be due to the selection of increased expression of a single or few important genes. However, systematic surveys of the copy...
A CHEK2 Genetic Variant Contributing to a Substantial Fraction of Familial Breast Cancer
Vahteristo, Pia, Bartkova, Jirina, Eerola, Hannaleena, Syrjäkoski, Kirsi, Ojala, Salla, Kilpivaara, Outi, ...
CHEK2 (previously known as “CHK2”) is a cell-cycle–checkpoint kinase that phosphorylates p53 and BRCA1 in response to DNA damage. A protein-truncating mutation, 1100delC in exon 10, which...
Moch, Holger, Schraml, Peter, Bubendorf, Lukas, Mirlacher, Martina, Kononen, Juha, Gasser, Thomas, ...
Many genes and signaling pathways are involved in renal cell carcinoma (RCC) development. However, genetic tumor markers have not gained use in RCC diagnostics and prognosis prediction....
Richter, Jan, Wagner, Urs, Kononen, Juha, Fijan, André, Bruderer, James, Schmid, Ulrico, ...
Studies by comparative genomic hybridization revealed that the 19q13 chromosomal region is frequently amplified in bladder cancer. The cyclin E gene (CCNE), coding for a regulatory subunit of...
Schraml, Peter, Struckmann, Kirsten, Bednar, Rudolf, Fu, Wenting, Gasser, Thomas, Wilber, Kim, ...
Inactivation of tumor suppressor genes on chromosome 9p is considered a critical event in renal cell carcinoma pathogenesis. Alterations of CDKN2A on 9p21 have been reported in renal cancer cell...
Tissue Microarrays for Rapid Linking of Molecular Changes to Clinical Endpoints
Torhorst, Joachim, Bucher, Christoph, Kononen, Juha, Haas, Philippe, Zuber, Markus, Köchli, Ossi R., ...
Advances in genomics and proteomics are dramatically increasing the need to evaluate large numbers of molecular targets for their diagnostic, predictive or prognostic value in clinical oncology....
Andersen, Claus L., Monni, Outi, Wagner, Urs, Kononen, Juha, Bärlund, Maarit, Bucher, Christoph, ...
The chromosomal region 17q23 has been shown to be commonly amplified in breast tumors, especially those with poor prognosis. In addition to breast cancer, studies by comparative genomic hybridization...
Van De Rijn, Matt, Perou, Charles M., Tibshirani, Rob, Haas, Phillippe, Kallioniemi, Olli, Kononen, Juha, ...
While several prognostic factors have been identified in breast carcinoma, the clinical outcome remains hard to predict for individual patients. Better predictive markers are needed to help guide...