Scientific Commons: Judith A. Erkmann

Mutations in the RNA Binding Domain of Stem-Loop Binding Protein Define Separable Requirements for RNA Binding and for Histone Pre-mRNA Processing

Dominski, Zbigniew, Erkmann, Judith A., Greenland, John A., Marzluff, William F.

Expression of replication-dependent histone genes at the posttranscriptional level is controlled by stem-loop binding protein (SLBP). One function of SLBP is to bind the stem-loop structure in the...

SLBP is associated with histone mRNA on polyribosomes as a component of the histone mRNP

Whitfield, Michael L., Kaygun, Handan, Erkmann, Judith A., Townley-Tilson, W. H. Davin, Dominski, Zbigniew, Marzluff, William F.

The stem–loop binding protein (SLBP) binds the 3′ end of histone mRNA and is present both in nucleus, and in the cytoplasm on the polyribosomes. SLBP participates in the processing of the histone...

Nuclear Import of the Stem–Loop Binding Protein and Localization during the Cell Cycle

Erkmann, Judith A., Wagner, Eric J., Dong, Jian, Zhang, Yanping, Kutay, Ulrike, Marzluff, William F.

A key factor involved in the processing of histone pre-mRNAs in the nucleus and translation of mature histone mRNAs in the cytoplasm is the stem–loop binding protein (SLBP). In this work, we have...

Nuclear export of metazoan replication-dependent histone mRNAs is dependent on RNA length and is mediated by TAP

ERKMANN, JUDITH A., SÀNCHEZ, RICARDO, TREICHEL, NATHALIE, MARZLUFF, WILLIAM F., KUTAY, ULRIKE

Replication-dependent histone mRNAs are the only metazoan mRNAs that are not polyadenylated, ending instead in a conserved stem–loop sequence. Histone pre-mRNAs lack introns and are processed in...

A novel zinc finger protein is associated with U7 snRNP and interacts with the stem–loop binding protein in the histone pre-mRNP to stimulate 3′-end processing

Dominski, Zbigniew, Erkmann, Judith A., Yang, Xiaocui, Sànchez, Ricardo, Marzluff, William F.

The stem–loop binding protein (SLBP) is the posttranscriptional regulator of histone mRNA in metazoan cells. SLBP binds histone pre-mRNAs and facilitates 3′-end processing by promoting stable...