Dogan, Soner, Hu, Xin, Zhang, Yan, Maihle, Nita J, Grande, Joseph P, Cleary, Margot P
Abstract Introduction Obesity is a risk factor for postmenopausal breast cancer and is associated with shortened mammary tumor (MT) latency in MMTV-TGF-α mice with dietary-induced obesity. One link...
Transgenic Sickle Mice Are Markedly Sensitive to Renal Ischemia-Reperfusion Injury
Nath, Karl A., Grande, Joseph P., Croatt, Anthony J., Frank, Elena, Caplice, Noel M., Hebbel, Robert P., ...
Ischemic injury is invoked as a mechanism contributing to end-organ damage and other complications of sickle cell disease (SCD). However, the intrinsic sensitivity of tissues in SCD to ischemic...
Anomalous Renal Effects of Tin Protoporphyrin in a Murine Model of Sickle Cell Disease
Juncos, Julio P., Grande, Joseph P., Murali, Narayana, Croatt, Anthony J., Juncos, Luis A., Hebbel, Robert P., ...
In human and murine models of sickle cell disease (SCD), heme oxygenase-1 (HO-1) is induced in the kidney, an organ commonly involved in SCD. The present study assessed the role of HO-1 by using a...
Nath, Karl A., Haggard, Jill J., Croatt, Anthony J., Grande, Joseph P., Poss, Kenneth D., Alam, Jawed
Heme oxygenase (HO) is the rate limiting enzyme in the degradation of heme, and its isozyme, HO-1, may protect against tissue injury. One posited mechanism is the degradation of heme released from...
Oxidative Stress and Induction of Heme Oxygenase-1 in the Kidney in Sickle Cell Disease
Nath, Karl A., Grande, Joseph P., Haggard, Jill J., Croatt, Anthony J., Katusic, Zvonimir S., Solovey, Anna, ...
Chronic nephropathy is a recognized complication of sickle cell disease. Using a transgenic sickle mouse, we examined whether oxidative stress occurs in the sickle kidney, the origins and functional...
Nath, Karl A., Kanakiriya, Sharan K. R., Grande, Joseph P., Croatt, Anthony J., Katusic, Zvonimir S.
We hypothesized that the venous limb of an arteriovenous (AV) fistula would evince up-regulation of genes relevant to vascular remodeling along with neointimal hyperplasia and relevant histological...
Renal Hemodynamic, Inflammatory, and Apoptotic Responses to Lipopolysaccharide in HO-1−/− Mice
Tracz, Michal J., Juncos, Julio P., Grande, Joseph P., Croatt, Anthony J., Ackerman, Allan W., Rajagopalan, Govindarajan, ...
Lipopolysaccharide (LPS) induces the stress-responsive gene heme oxygenase-1 (HO-1). The present study examined the significance of HO-1 in response to LPS. In HO-1−/− mice, as compared with...