Joseph P. Gaut

Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis

Gaut, Joseph P., Yeh, George C., Tran, Hung Duy, Byun, Jaeman, Henderson, Jeffrey P., Richter, Grace M., ...

The myeloperoxidase system of neutrophils uses hydrogen peroxide and chloride to generate hypochlorous acid, a potent bactericidal oxidant in vitro. In a mouse model of polymicrobial sepsis, we...

Myeloperoxidase produces nitrating oxidants in vivo

Gaut, Joseph P., Byun, Jaeman, Tran, Hung D., Lauber, Wendy M., Carroll, James A., Hotchkiss, Richard S., ...

Despite intense interest in pathways that generate reactive nitrogen species, the physiologically relevant mechanisms for inflammatory tissue injury remain poorly understood. One possible mediator is...

Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis

Gaut, Joseph P., Yeh, George C., Tran, Hung Duy, Byun, Jaeman, Henderson, Jeffrey P., Richter, Grace M., ...

The myeloperoxidase system of neutrophils uses hydrogen peroxide and chloride to generate hypochlorous acid, a potent bactericidal oxidant in vitro. In a mouse model of polymicrobial sepsis, we...

Myeloperoxidase produces nitrating oxidants in vivo

Gaut, Joseph P., Byun, Jaeman, Tran, Hung D., Lauber, Wendy M., Carroll, James A., Hotchkiss, Richard S., ...

Despite intense interest in pathways that generate reactive nitrogen species, the physiologically relevant mechanisms for inflammatory tissue injury remain poorly understood. One possible mediator is...