Joseph Mikusa

Effects of A-317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration

McGaraughty, Steve, Wismer, Carol T, Zhu, Chang Z, Mikusa, Joseph, Honore, Prisca, Chu, Katharine L, ...

We have recently reported that systemic delivery of A-317491, the first non-nucleotide antagonist that has high affinity and selectivity for blocking P2X3 homomeric and P2X2/3 heteromeric channels,...

Endogenous opioid mechanisms partially mediate P2X3/P2X2/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain

McGaraughty, Steve, Honore, Prisca, Wismer, Carol T, Mikusa, Joseph, Zhu, Chang Z, McDonald, Heath A, ...

P2X3/P2X2/3 receptors have emerged as important components of nociception. However, there is limited information regarding the neurochemical systems that are affected by antagonism of the P2X3/P2X2/3...