Jeroen P. Roose, Maximilian Diehn, Michael G. Tomlinson, Joseph Lin, Ash A. Alizadeh, David Botstein, ...
In the absence of basal signaling, RAG activity is high at a time during T cell development when it is otherwise normally suppressed.
Jeroen P. Roose, Maximilian Diehn, Michael G. Tomlinson, Joseph Lin, Ash A. Alizadeh, David Botstein, ...
Signal transduction pathways guided by cellular receptors commonly exhibit low-level constitutive signaling in a continuous, ligand-independent manner. The dynamic equilibrium of positive and...
Factors involved with the activation of the protein tyrosine kinase itk / (1998)
Thesis (M.S.)--University of California, San Diego, 1998.
T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression
Roose, Jeroen P, Diehn, Maximilian, Tomlinson, Michael G, Lin, Joseph, Alizadeh, Ash A, Botstein, David, ...
Signal transduction pathways guided by cellular receptors commonly exhibit low-level constitutive signaling in a continuous, ligand-independent manner. The dynamic equilibrium of positive and...
T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression
Roose, Jeroen P, Diehn, Maximilian, Tomlinson, Michael G, Lin, Joseph, Alizadeh, Ash A, Botstein, David, ...
Signal transduction pathways guided by cellular receptors commonly exhibit low-level constitutive signaling in a continuous, ligand-independent manner. The dynamic equilibrium of positive and...
Friend, Lindzy D., Shah, Dulari D., Deppong, Christine, Lin, Joseph, Bricker, Traci L., Juehne, Twyla I., ...
Activation of naive T cells requires the integration of signals through the antigen receptor and CD28. Although there is agreement on the importance of CD28, there remains controversy on the...
NF90 regulates inducible IL-2 gene expression in T cells
Shi, Lingfang, Godfrey, Wayne R., Lin, Joseph, Zhao, Guohua, Kao, Peter N.
Activation of T cells induces the production of T cell growth and survival factor interleukin (IL) 2. Regulatory T cells intrinsically fail to induce IL-2 expression upon activation and can suppress...
The c-SMAC: sorting it all out (or in)
Lin, Joseph, Miller, Mark J., Shaw, Andrey S.
T cells integrate and transduce the key signals necessary to mount an appropriate immune response. To do this, they rely on both secreted factors as well as physical cell–cell contact. Much...
CD148 is a receptor-like protein tyrosine phosphatase up-regulated on T cells after T cell receptor (TCR) stimulation. To examine the physiologic role of CD148 in TCR signaling, we used an inducible...