Joseph DeYoung

Letter. Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies (2006)

Service, Susan, DeYoung, Joseph, Karayiorgou, Maria, Roos, J. Louw, Pretorious, Herman, Bedoya, Gabriel, ...

The genome-wide distribution of linkage disequilibrium (LD) determines the strategy for selecting markers for association studies, but it varies between populations. We assayed LD in large samples...

Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies (2006)

Service, Susan, DeYoung, Joseph, Karayiorgou, Maria, Roos, J. Louw, Pretorious, Herman, Bedoya, Gabriel, ...

The genome-wide distribution of linkage disequilibrium (LD) determines the strategy for selecting markers for association studies, but it varies between populations. We assayed LD in large samples...

Natural variation in human membrane transporter genes reveals evolutionary and functional constraints

Leabman, Maya K., Huang, Conrad C., DeYoung, Joseph, Carlson, Elaine J., Taylor, Travis R., De La Cruz, Melanie, ...

Membrane transporters maintain cellular and organismal homeostasis by importing nutrients and exporting toxic compounds. Transporters also play a crucial role in drug response, serving as drug...

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1

Shu, Yan, Leabman, Maya K., Feng, Bo, Mangravite, Lara M., Huang, Conrad C., Stryke, Doug, ...

The organic cation transporter, OCT1, is a major hepatic transporter that mediates the uptake of many organic cations from the blood into the liver where the compounds may be metabolized or secreted...

Hereditary Vascular Retinopathy, Cerebroretinal Vasculopathy, and Hereditary Endotheliopathy with Retinopathy, Nephropathy, and Stroke Map to a Single Locus on Chromosome 3p21.1-p21.3

Ophoff, Roel A., DeYoung, Joseph, Service, Susan K., Joosse, Marijke, Caffo, Nathan A., Sandkuijl, Lodewijk A., ...

We performed a genomewide search for linkage in an extended Dutch family with hereditary vascular retinopathy associated with migraine and Raynaud phenomenon. Patients with vascular retinopathy are...

Natural variation in human membrane transporter genes reveals evolutionary and functional constraints

Leabman, Maya K., Huang, Conrad C., DeYoung, Joseph, Carlson, Elaine J., Taylor, Travis R., De La Cruz, Melanie, ...

Membrane transporters maintain cellular and organismal homeostasis by importing nutrients and exporting toxic compounds. Transporters also play a crucial role in drug response, serving as drug...

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1

Shu, Yan, Leabman, Maya K., Feng, Bo, Mangravite, Lara M., Huang, Conrad C., Stryke, Doug, ...

The organic cation transporter, OCT1, is a major hepatic transporter that mediates the uptake of many organic cations from the blood into the liver where the compounds may be metabolized or secreted...

Hereditary Vascular Retinopathy, Cerebroretinal Vasculopathy, and Hereditary Endotheliopathy with Retinopathy, Nephropathy, and Stroke Map to a Single Locus on Chromosome 3p21.1-p21.3

Ophoff, Roel A., DeYoung, Joseph, Service, Susan K., Joosse, Marijke, Caffo, Nathan A., Sandkuijl, Lodewijk A., ...

We performed a genomewide search for linkage in an extended Dutch family with hereditary vascular retinopathy associated with migraine and Raynaud phenomenon. Patients with vascular retinopathy are...