David S. Shames, Luc Girard, Boning Gao, Mitsuo Sato, Cheryl M. Lewis, Narayan Shivapurkar, ...
BackgroundPromoter hypermethylation coupled with loss of heterozygosity at the same locus results in loss of gene function in many tumor cells. The “rules” governing which genes are methylated...
Correction: A DNA microarray survey of gene expression in normal human tissues (2005)
Shyamsundar, Radha, Kim, Young H, Higgins, John P, Montgomery, Kelli, Jorden, Michelle, Sethuraman, Anand, ...
No abstract available.
A DNA microarray survey of gene expression in normal human tissues (2005)
Shyamsundar, Radha, Kim, Young H, Higgins, John P, Montgomery, Kelli, Jorden, Michelle, Sethuraman, Anand, ...
Abstract Background Numerous studies have used DNA microarrays to survey gene expression in cancer and other disease states. Comparatively little is known about the genes expressed across the gamut...
Jeffrey, Stefanie S, Pollack, Jonathan R
Abstract Array-based comparative genomic hybridization, RNA expression profiling, and proteomic analyses are new molecular technologies used to study breast cancer. Invasive breast cancers were...
A transcriptional response to Wnt protein in human embryonic carcinoma cells (2002)
Willert, Jennifer, Epping, Mirjam, Pollack, Jonathan R, Brown, Patrick O, Nusse, Roel
Abstract Background Wnt signaling is implicated in many developmental decisions, including stem cell control, as well as in cancer. There are relatively few target genes known of the Wnt pathway....
Lin, Johann Y, Pollack, Jonathan R, Chou, Fan-Li, Rees, Christian A, Christian, Allen T, Bedford, Joel S, ...
Abstract Background Somatic cell mutants can be informative in the analysis of a wide variety of cellular processes. The use of map-based positional cloning strategies in somatic cell hybrids to...
Lin, Johann Y, Pollack, Jonathan R, Chou, Fan-Li, Rees, Christian A, Christian, Allen T, Bedford, Joel S, ...
A transcriptional response to Wnt protein in human embryonic carcinoma cells
Willert, Jennifer, Epping, Mirjam, Pollack, Jonathan R, Brown, Patrick O, Nusse, Roel
Pollack, Jonathan R., Sørlie, Therese, Perou, Charles M., Rees, Christian A., Jeffrey, Stefanie S., Lonning, Per E., ...
Genomic DNA copy number alterations are key genetic events in the development and progression of human cancers. Here we report a genome-wide microarray comparative genomic hybridization (array CGH)...
Jeffrey, Stefanie S, Pollack, Jonathan R
Array-based comparative genomic hybridization, RNA expression profiling, and proteomic analyses are new molecular technologies used to study breast cancer. Invasive breast cancers were originally...
Gene expression profiling identifies clinically relevant subtypes of prostate cancer
Lapointe, Jacques, Li, Chunde, Higgins, John P., Van De Rijn, Matt, Bair, Eric, Montgomery, Kelli, ...
Prostate cancer, a leading cause of cancer death, displays a broad range of clinical behavior from relatively indolent to aggressive metastatic disease. To explore potential molecular variation...
A DNA microarray survey of gene expression in normal human tissues
Shyamsundar, Radha, Kim, Young H, Higgins, John P, Montgomery, Kelli, Jorden, Michelle, Sethuraman, Anand, ...
A systematic survey of gene expression in 115 human tissue samples using cDNA microarrays provides a dataset that can be used as a baseline for comparison with expression in diseased tissue.
Correction: A DNA microarray survey of gene expression in normal human tissues
Shyamsundar, Radha, Kim, Young H, Higgins, John P, Montgomery, Kelli, Jorden, Michelle, Sethuraman, Anand, ...
A correction to A DNA microarray survey of gene expression in normal human tissues by R Shyamsundar, YH Kim, JP Higgins, K Montgomery, M Jorden, A Sethuraman, M van de Rijn, D Botstein, PO Brown and...
Bashyam, Murali D, Bair, Ryan, Kim, Young H, Wang, Pei, Hernandez-Boussard, Tina, Karikari, Collins A, ...
Pancreatic cancer, the fourth leading cause of cancer death in the United States, is frequently associated with the amplification and deletion of specific oncogenes and tumor-suppressor genes (TSGs),...
Lin, Johann Y, Pollack, Jonathan R, Chou, Fan-Li, Rees, Christian A, Christian, Allen T, Bedford, Joel S, ...
A transcriptional response to Wnt protein in human embryonic carcinoma cells
Willert, Jennifer, Epping, Mirjam, Pollack, Jonathan R, Brown, Patrick O, Nusse, Roel
Pollack, Jonathan R., Sørlie, Therese, Perou, Charles M., Rees, Christian A., Jeffrey, Stefanie S., Lonning, Per E., ...
Genomic DNA copy number alterations are key genetic events in the development and progression of human cancers. Here we report a genome-wide microarray comparative genomic hybridization (array CGH)...
Jeffrey, Stefanie S, Pollack, Jonathan R
Array-based comparative genomic hybridization, RNA expression profiling, and proteomic analyses are new molecular technologies used to study breast cancer. Invasive breast cancers were originally...
Gene expression profiling identifies clinically relevant subtypes of prostate cancer
Lapointe, Jacques, Li, Chunde, Higgins, John P., Van De Rijn, Matt, Bair, Eric, Montgomery, Kelli, ...
Prostate cancer, a leading cause of cancer death, displays a broad range of clinical behavior from relatively indolent to aggressive metastatic disease. To explore potential molecular variation...
A DNA microarray survey of gene expression in normal human tissues
Shyamsundar, Radha, Kim, Young H, Higgins, John P, Montgomery, Kelli, Jorden, Michelle, Sethuraman, Anand, ...
A systematic survey of gene expression in 115 human tissue samples using cDNA microarrays provides a dataset that can be used as a baseline for comparison with expression in diseased tissue.
Correction: A DNA microarray survey of gene expression in normal human tissues
Shyamsundar, Radha, Kim, Young H, Higgins, John P, Montgomery, Kelli, Jorden, Michelle, Sethuraman, Anand, ...
A correction to A DNA microarray survey of gene expression in normal human tissues by R Shyamsundar, YH Kim, JP Higgins, K Montgomery, M Jorden, A Sethuraman, M van de Rijn, D Botstein, PO Brown and...
Bashyam, Murali D, Bair, Ryan, Kim, Young H, Wang, Pei, Hernandez-Boussard, Tina, Karikari, Collins A, ...
Pancreatic cancer, the fourth leading cause of cancer death in the United States, is frequently associated with the amplification and deletion of specific oncogenes and tumor-suppressor genes (TSGs),...
Shames, David S, Girard, Luc, Gao, Boning, Sato, Mitsuo, Lewis, Cheryl M, Shivapurkar, Narayan, ...
John Minna and colleagues report that a group of genes are commonly methylated in primary lung, breast, colon, and prostate cancer.
Gene Expression Patterns in Renal Cell Carcinoma Assessed by Complementary DNA Microarray
Higgins, John P.T., Shinghal, Rajesh, Gill, Harcharan, Reese, Jeffrey H., Terris, Martha, Cohen, Ronald J., ...
Renal cell carcinoma comprises several histological types with different clinical behavior. Accurate pathological characterization is important in the clinical management of these tumors. We describe...
Gene Expression Patterns and Gene Copy Number Changes in Dermatofibrosarcoma Protuberans
Linn, Sabine C., West, Rob B., Pollack, Jonathan R., Zhu, Shirley, Hernandez-Boussard, Tina, Nielsen, Torsten O., ...
Dermatofibrosarcoma protuberans (DFSP) is an aggressive spindle cell neoplasm. It is associated with the chromosomal translocation, t(17:22), which fuses the COL1A1 and PDGFβ genes. We determined...
Bredel, Markus, Bredel, Claudia, Juric, Dejan, Kim, Young, Vogel, Hannes, Harsh, Griffith R., ...
Sufficient quantity of genomic DNA can be a bottleneck in genome-wide analysis of clinical tissue samples. DNA polymerase Phi29 can be used for the random-primed amplification of whole genomes,...
A Perspective on DNA Microarrays in Pathology Research and Practice
DNA microarray technology matured in the mid-1990s, and the past decade has witnessed a tremendous growth in its application. DNA microarrays have provided powerful tools for pathology researchers...
Gene copy number variation spanning 60 million years of human and primate evolution
Dumas, Laura, Kim, Young H., Karimpour-Fard, Anis, Cox, Michael, Hopkins, Janet, Pollack, Jonathan R., ...
Given the evolutionary importance of gene duplication to the emergence of species-specific traits, we have extended the application of cDNA array-based comparative genomic hybridization (aCGH) to...
Genomic Profiling Identifies GATA6 as a Candidate Oncogene Amplified in Pancreatobiliary Cancer
Kwei, Kevin A., Bashyam, Murali D., Kao, Jessica, Ratheesh, Raman, Reddy, Edumakanti C., Kim, Young H., ...
Pancreatobiliary cancers have among the highest mortality rates of any cancer type. Discovering the full spectrum of molecular genetic alterations may suggest new avenues for therapy. To catalogue...