Dahlén, Anna, Fletcher, Christopher D M, Mertens, Fredrik, Fletcher, Jonathan A, Perez-Atayde, Antonio R, Hicks, M John, ...
Abstract is not available
The chimeric FUS/CREB3l2 gene is specific for low-grade fibromyxoid sarcoma. (2004)
Panagopoulos, Ioannis, Tiziana Storlazzi, Clelia, Fletcher, Christopher D M, Fletcher, Jonathan A, Nascimento, Antonio, Domanski, Henryk A, ...
Abstract is not available
Panagopoulos, Ioannis, Mertens, Fredrik, Isaksson, Margareth, Domanski, Henryk A, Brosjö, Otte, Heim, Sverre, ...
Extraskeletal myxoid chondrosarcoma (EMC) is a soft-tissue neoplasm cytogenetically characterized by the translocations t(9;22)(q22;q11-12) or t(9;17)(q22;q11), generating EWS/CHN or RBP56/CHN fusion...
Zhao, Jiyong, Kennedy, Brian K., Lawrence, Brandon D., Barbie, David A., Matera, A. Gregory, Fletcher, Jonathan A., ...
In eukaryotic cells, histone gene expression is one of the major events that mark entry into S phase. While this process is tightly linked to cell cycle position, how it is regulated by the cell...
Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors
Koontz, Jason I., Soreng, A. Lee, Nucci, Marisa, Kuo, Frank C., Pauwels, Patrick, Van Den Berghe, Herman, ...
Endometrial stromal tumors are divided into three types: benign stromal nodules, endometrial stromal sarcomas, and undifferentiated endometrial sarcomas. A variety of cytogenetic abnormalities...
PPARγ ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis
Panigrahy, Dipak, Singer, Samuel, Shen, Lucy Q., Butterfield, Catherine E., Freedman, Deborah A., Chen, Emy J., ...
Several drugs approved for a variety of indications have been shown to exhibit antiangiogenic effects. Our study focuses on the PPARγ ligand rosiglitazone, a compound widely used in the treatment of...
Davis, Ian J., Hsi, Bae-Li, Arroyo, Jason D., Vargas, Sara O., Yeh, Y. Albert, Motyckova, Gabriela, ...
MITF, TFE3, TFEB, and TFEC comprise a transcription factor family (MiT) that regulates key developmental pathways in several cell lineages. Like MYC, MiT members are basic helix-loop-helix-leucine...
NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcription
Zhao, Jiyong, Kennedy, Brian K., Lawrence, Brandon D., Barbie, David A., Matera, A. Gregory, Fletcher, Jonathan A., ...
In eukaryotic cells, histone gene expression is one of the major events that mark entry into S phase. While this process is tightly linked to cell cycle position, how it is regulated by the cell...
Chen, Jing, DeAngelo, Daniel J., Kutok, Jeffery L., Williams, Ifor R., Lee, Benjamin H., Wadleigh, Martha, ...
Human stem cell leukemia-lymphoma syndrome usually presents itself as a myeloproliferative disorder (MPD) that evolves to acute myeloid leukemia and/or lymphoma. The syndrome associated with...
Limitations of Chromosome Classification by Multicolor Karyotyping
Lee, Charles, Gisselsson, David, Jin, Charlotte, Nordgren, Ann, Ferguson, David O., Blennow, Elisabeth, ...
Multicolor karyotyping technologies, such as spectral karyotyping (SKY) (Schröck et al. 1996; Liyanage et al. 1996) and multiplex (M-) FISH (Speicher et al. 1996), have proved to be extremely useful...
Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors
Koontz, Jason I., Soreng, A. Lee, Nucci, Marisa, Kuo, Frank C., Pauwels, Patrick, Van Den Berghe, Herman, ...
Endometrial stromal tumors are divided into three types: benign stromal nodules, endometrial stromal sarcomas, and undifferentiated endometrial sarcomas. A variety of cytogenetic abnormalities...
PPARγ ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis
Panigrahy, Dipak, Singer, Samuel, Shen, Lucy Q., Butterfield, Catherine E., Freedman, Deborah A., Chen, Emy J., ...
Several drugs approved for a variety of indications have been shown to exhibit antiangiogenic effects. Our study focuses on the PPARγ ligand rosiglitazone, a compound widely used in the treatment of...
Davis, Ian J., Hsi, Bae-Li, Arroyo, Jason D., Vargas, Sara O., Yeh, Y. Albert, Motyckova, Gabriela, ...
MITF, TFE3, TFEB, and TFEC comprise a transcription factor family (MiT) that regulates key developmental pathways in several cell lineages. Like MYC, MiT members are basic helix-loop-helix-leucine...
NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcription
Zhao, Jiyong, Kennedy, Brian K., Lawrence, Brandon D., Barbie, David A., Matera, A. Gregory, Fletcher, Jonathan A., ...
In eukaryotic cells, histone gene expression is one of the major events that mark entry into S phase. While this process is tightly linked to cell cycle position, how it is regulated by the cell...
Chen, Jing, DeAngelo, Daniel J., Kutok, Jeffery L., Williams, Ifor R., Lee, Benjamin H., Wadleigh, Martha, ...
Human stem cell leukemia-lymphoma syndrome usually presents itself as a myeloproliferative disorder (MPD) that evolves to acute myeloid leukemia and/or lymphoma. The syndrome associated with...
Limitations of Chromosome Classification by Multicolor Karyotyping
Lee, Charles, Gisselsson, David, Jin, Charlotte, Nordgren, Ann, Ferguson, David O., Blennow, Elisabeth, ...
Multicolor karyotyping technologies, such as spectral karyotyping (SKY) (Schröck et al. 1996; Liyanage et al. 1996) and multiplex (M-) FISH (Speicher et al. 1996), have proved to be extremely useful...
KIT Mutations Are Common in Testicular Seminomas
Kemmer, Kathleen, Corless, Christopher L., Fletcher, Jonathan A., McGreevey, Laura, Haley, Andrea, Griffith, Diana, ...
Expression of KIT tyrosine kinase is critical for normal germ cell development and is observed in the majority of seminomas. Activating mutations in KIT are common in gastrointestinal stromal tumors...
Dahlén, Anna, Fletcher, Christopher D. M., Mertens, Fredrik, Fletcher, Jonathan A., Perez-Atayde, Antonio R., Hicks, M. John, ...
Activation of the GLI oncogene is an important step in the sonic hedgehog signaling pathway, and leads to, eg, tissue-specific cell proliferation during embryogenesis. GLI activity in adult tissues...
KIT Extracellular and Kinase Domain Mutations in Gastrointestinal Stromal Tumors
Lux, Marcia L., Rubin, Brian P., Biase, Tara L., Chen, Chang-Jie, Maclure, Timothy, Demetri, George, ...
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms arising in the gastrointestinal tract. GISTs express the KIT receptor tyrosine kinase, and many cases have activating...
Subtracted, Unique-Sequence, In Situ Hybridization : Experimental and Diagnostic Applications
Davison, Jon M., Morgan, Thomas W., Hsi, Bae-Li, Xiao, Sheng, Fletcher, Jonathan A.
Nonrandom chromosomal aberrations, particularly in cancer, identify pathogenic biological pathways and, in some cases, have clinical relevance as diagnostic or prognostic markers. Fluorescence and...
Rubin, Brian P., Chen, Chang-Jie, Morgan, Thomas W., Xiao, Sheng, Grier, Holcombe E., Kozakewich, Harry P., ...
Morphological, cytogenetic, and biological evidence supports a relationship between congenital (infantile) fibrosarcoma (CFS) and congenital mesoblastic nephroma (CMN). These tumors have a very...
TPM3-ALK and TPM4-ALK Oncogenes in Inflammatory Myofibroblastic Tumors
Lawrence, Brandon, Perez-Atayde, Antonio, Hibbard, Michele K., Rubin, Brian P., Dal Cin, Paola, Pinkus, Jack L., ...
Inflammatory myofibroblastic tumors (IMTs) are neoplastic mesenchymal proliferations featuring an inflammatory infiltrate composed primarily of lymphocytes and plasma cells. The myofibroblastic cells...
Argani, Pedram, Antonescu, Cristina R., Illei, Peter B., Lui, Man Yee, Timmons, Charles F., Newbury, Robert, ...
The unbalanced translocation, der(17)t(X;17)(p11.2;q25), is characteristic of alveolar soft part sarcoma (ASPS). We have recently shown that this translocation fuses the TFE3 transcription factor...
Gisselsson, David, Hibbard, Michele K., Dal Cin, Paola, Sciot, Raf, Hsi, Bae-Li, Kozakewich, Harry P., ...
Lipoblastomas are rare soft tissue tumors that occur primarily in young children. They typically contain variably differentiated adipocytes, primitive mesenchymal cells, myxoid matrix, and fibrous...
BRD4 Bromodomain Gene Rearrangement in Aggressive Carcinoma with Translocation t(15;19)
French, Christopher A., Miyoshi, Isao, Aster, Jon C., Kubonishi, Ichiro, Kroll, Todd G., Dal Cin, Paola, ...
Translocation t(15;19)(q13;p13.1) defines a lethal midline carcinoma arising adjacent to respiratory tract in young people. To characterize molecular alterations responsible for the distinctly...
KIT Gene Mutations in Gastrointestinal Stromal Tumors : More Complex than Previously Recognized?
Fletcher, Jonathan A., Fletcher, Christopher D.M., Rubin, Brian P., Ashman, Leonie K., Corless, Christopher L., Heinrich, Michael C.
Genetic and Biological Subgroups of Low-Stage Follicular Thyroid Cancer
French, Christopher A., Alexander, Erik K., Cibas, Edmund S., Nose, Vania, Laguette, Julia, Faquin, William, ...
Investigations of cancer-specific gene rearrangements have increased our understanding of human neoplasia and led to the use of the rearrangements in pathological diagnosis of blood cell and...
KIT Gene Deletions at the Intron 10−Exon 11 Boundary in GI Stromal Tumors
Corless, Christopher L., McGreevey, Laura, Town, Ajia, Schroeder, Arin, Bainbridge, Troy, Harrell, Patina, ...
Most gastrointestinal stromal tumors (GISTs) harbor oncogenic mutations in the KIT gene, and the majority of these mutations affect the juxtamembrane domain of the kinase encoded by exon 11....