Cynomolgus Macaque as an Animal Model for Severe Acute Respiratory Syndrome (2006)
James V. Lawler, Timothy P. Endy, Lisa E. Hensley, Aura Garrison, Elizabeth A. Fritz, May Lesar, ...
Jason Paragas and colleagues report the first findings of measurable clinical disease in nonhuman primates infected with the virus that causes SARS, SARS-CoV.
Cynomolgus Macaque as an Animal Model for Severe Acute Respiratory Syndrome (2006)
James V. Lawler, Timothy P. Endy, Lisa E. Hensley, Aura Garrison, Elizabeth A. Fritz, May Lesar, ...
BackgroundThe emergence of severe acute respiratory syndrome (SARS) in 2002 and 2003 affected global health and caused major economic disruption. Adequate animal models are required to study the...
Interferon-Beta 1a and SARS Coronavirus Replication (2004)
Hensley, Lisa E ., Fritz, Elizabeth A., Jahrling, Peter B., Karp, Christopher L., Huggins, John W.
A global outbreak of severe acute respiratory syndrome (SARS) caused by a novel coronavirus began in March 2003. The rapid emergence of SARS and the substantial illness and death it caused have made...
Ribavirin Prophylaxis and Therapy for Experimental Argentine Hemorrhagic Fever, (1998)
Huggins, John W., Trahan, Creighton J., Mahlandt, Bill G.
Junin virus-infected rhesus macaques received prophylactic and therapeutic ribavirin to assess the potential of this drug for treating humans with Argentine hemorrhagic fever. When ribavirin was...
Chin-Min, Hsiang, Zhi-Ming, Zheng, Huggins, John W.
To hold an International Symposium in HFRS was initially proposed by Dr. Chin-min Hsiang, Professor of Virology of Hubei Medical University and immediately supported by Dr. Jia-qi Yang, president of...
Paragas, Jason, Blatt, Lawrence M., Hartmann, Chris, Huggins, John W., Endy, Tim P.
Preliminary data examining interferon alfacon1 treatment of SARS-CoV (severe acute respiratory syndrome - corona virus)-infected patients suggests this therapy is well tolerated and of therapeutic...
Interferon Alfacon1 is a Potent Inhibitor of SARS-Corona Virus in Cell-Based Models (1998)
Paragas, Jason, Blatt, Lawrence M., Hartmann, Chris, Huggins, John W., Endy, Tim P.
Preliminary data examining interferon alphacon1 treatment of SARS-CoV (severe acute respiratory syndrome-corona virus)-infected patients suggest this therapy is well tolerated and of therapeutic...
Smee, Donald F., Sidwell, Robert W., Kefauver, Debbie, Bray, Mike, Huggins, John W.
Cidofovir {[(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine] [HPMPC]}-resistant forms of camelpox, cowpox, monkeypox, and vaccinia viruses were developed by prolonged passage in Vero 76 cells in...
Inhibition of RNA Viruses In Vitro and in Rift Valley Fever-Infected Mice by Didemnins A and B
Canonico, Peter G., Pannier, Wallace L., Huggins, John W., Rienehart, Kenneth L.
Didemnins, a new class of depsipeptides isolated from a Caribbean tunicate, have been shown to have potent antiviral activity against a broad range of RNA viruses in vitro. Didemnins A and B both...
Rubins, Kathleen H., Hensley, Lisa E., Jahrling, Peter B., Whitney, Adeline R., Geisbert, Thomas W., Huggins, John W., ...
Smallpox has played an unparalleled role in human history and remains a significant potential threat to public health. Despite the historical significance of this disease, we know little about the...
Jahrling, Peter B., Hensley, Lisa E., Martinez, Mark J., LeDuc, James W., Rubins, Kathleen H., Relman, David A., ...
Smallpox virus (variola) poses a significant threat as an agent of bioterrorism. To mitigate this risk, antiviral drugs and an improved vaccine are urgently needed. Satisfactory demonstration of...
Yang, Guang, Pevear, Daniel C., Davies, Marc H., Collett, Marc S., Bailey, Tom, Rippen, Susan, ...
ST-246 is a low-molecular-weight compound (molecular weight = 376), that is potent (concentration that inhibited virus replication by 50% = 0.010 μM), selective (concentration of compound that...
Cynomolgus Macaque as an Animal Model for Severe Acute Respiratory Syndrome
Lawler, James V, Endy, Timothy P, Hensley, Lisa E, Garrison, Aura, Fritz, Elizabeth A, Lesar, May, ...
Jason Paragas and colleagues report the first findings of measurable clinical disease in nonhuman primates infected with the virus that causes SARS, SARS-CoV.
Smee, Donald F., Sidwell, Robert W., Kefauver, Debbie, Bray, Mike, Huggins, John W.
Cidofovir {[(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine] [HPMPC]}-resistant forms of camelpox, cowpox, monkeypox, and vaccinia viruses were developed by prolonged passage in Vero 76 cells in...
Inhibition of RNA Viruses In Vitro and in Rift Valley Fever-Infected Mice by Didemnins A and B
Canonico, Peter G., Pannier, Wallace L., Huggins, John W., Rienehart, Kenneth L.
Didemnins, a new class of depsipeptides isolated from a Caribbean tunicate, have been shown to have potent antiviral activity against a broad range of RNA viruses in vitro. Didemnins A and B both...
Rubins, Kathleen H., Hensley, Lisa E., Jahrling, Peter B., Whitney, Adeline R., Geisbert, Thomas W., Huggins, John W., ...
Smallpox has played an unparalleled role in human history and remains a significant potential threat to public health. Despite the historical significance of this disease, we know little about the...
Jahrling, Peter B., Hensley, Lisa E., Martinez, Mark J., LeDuc, James W., Rubins, Kathleen H., Relman, David A., ...
Smallpox virus (variola) poses a significant threat as an agent of bioterrorism. To mitigate this risk, antiviral drugs and an improved vaccine are urgently needed. Satisfactory demonstration of...
Yang, Guang, Pevear, Daniel C., Davies, Marc H., Collett, Marc S., Bailey, Tom, Rippen, Susan, ...
ST-246 is a low-molecular-weight compound (molecular weight = 376), that is potent (concentration that inhibited virus replication by 50% = 0.010 μM), selective (concentration of compound that...
Cynomolgus Macaque as an Animal Model for Severe Acute Respiratory Syndrome
Lawler, James V, Endy, Timothy P, Hensley, Lisa E, Garrison, Aura, Fritz, Elizabeth A, Lesar, May, ...
Jason Paragas and colleagues report the first findings of measurable clinical disease in nonhuman primates infected with the virus that causes SARS, SARS-CoV.