John L. Fahey

Impaired response to HAART in HIV-infected individuals with high autonomic nervous system activity

Cole, Steve W., Naliboff, Bruce D., Kemeny, Margaret E., Griswold, Marshall P., Fahey, John L., Zack, Jerome A.

Neurotransmitters can accelerate HIV-1 replication in vitro, leading us to examine whether differences in autonomic nervous system (ANS) activity might promote residual HIV-1 replication in patients...

Oral Fluids as an Alternative to Serum for Measurement of Markers of Immune Activation

Nishanian, Parunag, Aziz, Najib, Chung, Joanie, Detels, Roger, Fahey, John L.

Oral fluids are convenient alternatives to blood sampling for evaluating significant metabolic components. Two forms of oral fluids, oral mucosal transudates (OMT) and saliva, were collected and...

Variables That Affect Assays for Plasma Cytokines and Soluble Activation Markers

Aziz, Najib, Nishanian, Parunag, Mitsuyasu, Ronald, Detels, Roger, Fahey, John L.

Cytokines and soluble immune activation markers that reflect cytokine activities in vivo are increasingly being measured in plasma, serum, and other body fluids. They provide useful diagnostic and...

Need for an External Proficiency Testing Program for Cytokines, Chemokines, and Plasma Markers of Immune Activation

Fahey, John L., Aziz, Najib, Spritzler, John, Plaeger, Susan, Nishanian, Parunag, Lathey, Janet L., ...

An external evaluation program for measuring the performance of laboratories testing for cytokines and immune activation markers in biological fluids was developed. Cytokines, chemokines, soluble...

Cytokine Gene Expression Occurs More Rapidly in Stimulated Peripheral Blood Mononuclear Cells from Human Immunodeficiency Virus-Infected Persons

Breen, Elizabeth Crabb, McDonald, Matthew, Fan, Jiang, Boscardin, John, Fahey, John L.

Evaluation of cytokine gene expression following in vitro stimulation is one means of examining the dysregulation of the immune system in human immunodeficiency virus (HIV) infection. We have...

Levels of Cytokines and Immune Activation Markers in Plasma in Human Immunodeficiency Virus Infection: Quality Control Procedures

Aziz, Najib, Nishanian, Parunag, Fahey, John L.

Procedures for quality control (QC) in a laboratory that concentrates on cytokine and soluble marker measurements in biological fluids are outlined. Intra-assay, interassay, and interlaboratory...

Cytokine Gene Expression in Normal Human Lymphocytes in Response to Stimulation

Fan, Jiang, Nishanian, Parunag, Breen, Elizabeth C., McDonald, Matthew, Fahey, John L.

Sequential gene expression of two type 1 cytokines (interleukin 2 [IL-2] and gamma interferon), one type 2 cytokine (IL-10), two monokines (IL-6 and tumor necrosis factor alpha), and one cytokine...

Analytical Performance of a Highly Sensitive C-Reactive Protein-Based Immunoassay and the Effects of Laboratory Variables on Levels of Protein in Blood

Aziz, Najib, Fahey, John L., Detels, Roger, Butch, Anthony W.

C-reactive protein (CRP) is an acute-phase reactant whose levels increase in response to a variety of inflammatory stimuli. Elevated levels in serum are observed after trauma, tissue necrosis,...

Biosynthetic And structural studies of a heavy chain disease protein

Ein, Daniel, Buell, Donald N., Fahey, John L.

A new heavy chain disease protein (γHCD-JM) has been characterized by antigenic and structural criteria. The protein belongs to the IgG3-subclass and is closely related to Fc-fragment of...

Preliminary evidence for lymphocyte distribution differences at rest and after acute psychological stress in PTSD-symptomatic women☆

Glover, Dorie A., Steele, Amber C., Stuber, Margaret L., Fahey, John L.

This study investigated circulating natural killer (NK), CD4+ and CD8+ cells in response to acute psychological challenge among mothers of child cancer survivors with and without posttraumatic stress...

Impaired response to HAART in HIV-infected individuals with high autonomic nervous system activity

Cole, Steve W., Naliboff, Bruce D., Kemeny, Margaret E., Griswold, Marshall P., Fahey, John L., Zack, Jerome A.

Neurotransmitters can accelerate HIV-1 replication in vitro, leading us to examine whether differences in autonomic nervous system (ANS) activity might promote residual HIV-1 replication in patients...

Oral Fluids as an Alternative to Serum for Measurement of Markers of Immune Activation

Nishanian, Parunag, Aziz, Najib, Chung, Joanie, Detels, Roger, Fahey, John L.

Oral fluids are convenient alternatives to blood sampling for evaluating significant metabolic components. Two forms of oral fluids, oral mucosal transudates (OMT) and saliva, were collected and...

Variables That Affect Assays for Plasma Cytokines and Soluble Activation Markers

Aziz, Najib, Nishanian, Parunag, Mitsuyasu, Ronald, Detels, Roger, Fahey, John L.

Cytokines and soluble immune activation markers that reflect cytokine activities in vivo are increasingly being measured in plasma, serum, and other body fluids. They provide useful diagnostic and...

Need for an External Proficiency Testing Program for Cytokines, Chemokines, and Plasma Markers of Immune Activation

Fahey, John L., Aziz, Najib, Spritzler, John, Plaeger, Susan, Nishanian, Parunag, Lathey, Janet L., ...

An external evaluation program for measuring the performance of laboratories testing for cytokines and immune activation markers in biological fluids was developed. Cytokines, chemokines, soluble...

Cytokine Gene Expression Occurs More Rapidly in Stimulated Peripheral Blood Mononuclear Cells from Human Immunodeficiency Virus-Infected Persons

Breen, Elizabeth Crabb, McDonald, Matthew, Fan, Jiang, Boscardin, John, Fahey, John L.

Evaluation of cytokine gene expression following in vitro stimulation is one means of examining the dysregulation of the immune system in human immunodeficiency virus (HIV) infection. We have...

Levels of Cytokines and Immune Activation Markers in Plasma in Human Immunodeficiency Virus Infection: Quality Control Procedures

Aziz, Najib, Nishanian, Parunag, Fahey, John L.

Procedures for quality control (QC) in a laboratory that concentrates on cytokine and soluble marker measurements in biological fluids are outlined. Intra-assay, interassay, and interlaboratory...

Cytokine Gene Expression in Normal Human Lymphocytes in Response to Stimulation

Fan, Jiang, Nishanian, Parunag, Breen, Elizabeth C., McDonald, Matthew, Fahey, John L.

Sequential gene expression of two type 1 cytokines (interleukin 2 [IL-2] and gamma interferon), one type 2 cytokine (IL-10), two monokines (IL-6 and tumor necrosis factor alpha), and one cytokine...

Analytical Performance of a Highly Sensitive C-Reactive Protein-Based Immunoassay and the Effects of Laboratory Variables on Levels of Protein in Blood

Aziz, Najib, Fahey, John L., Detels, Roger, Butch, Anthony W.

C-reactive protein (CRP) is an acute-phase reactant whose levels increase in response to a variety of inflammatory stimuli. Elevated levels in serum are observed after trauma, tissue necrosis,...

Biosynthetic And structural studies of a heavy chain disease protein

Ein, Daniel, Buell, Donald N., Fahey, John L.

A new heavy chain disease protein (γHCD-JM) has been characterized by antigenic and structural criteria. The protein belongs to the IgG3-subclass and is closely related to Fc-fragment of...

THE FORMATION OF MYELOMA PROTEIN BY A MOUSE PLASMA CELL TUMOR

Nathans, Daniel, Fahey, John L., Potter, Michael

The origin of the myeloma protein found in mice bearing the plasma cell tumor X5563 has been investigated. Specific activity-time curves of the myeloma proteins isolated from the tumor and from the...

PHYSICOCHEMICAL CHARACTERIZATION OF MOUSE MYELOMA PROTEINS: DEMONSTRATION OF HETEROGENEITY FOR EACH MYELOMA GLOBULIN

Fahey, John L.

Physicochemical characterization of mouse myeloma proteins revealed the individuality of each myeloma protein. When the myeloma proteins are considered collectively a wide range of individual...

IMMUNOCHEMICAL STUDIES OF TWENTY MOUSE MYELOMA PROTEINS: EVIDENCE FOR TWO GROUPS OF PROTEINS SIMILAR TO GAMMA AND BETA-2A GLOBULINS IN MAN

Fahey, John L.

The serum myeloma proteins associated with 20 mouse plasma cell tumors in C3H or BALB/c mice that had proved transplantable were characterized by electrophoretic and immunochemical techniques....

FACTORS CONTROLLING SERUM γ-GLOBULIN CONCENTRATION

Fahey, John L., Robinson, Alan G.

Both synthetic and catabolic processes determine the serum γ-globulin level. The rate of γ-globulin synthesis appears to be the primary factor determining the amount of serum γ-globulin. Increase...

THE IMMUNOGLOBULINS OF MICE : I. FOUR MAJOR CLASSES OF IMMUNOGLOBULINS: 7S γ2-, 7S γ1-, γ1A (β2A)-, AND 18S γ1M-GLOBULINS

Fahey, John L., Wunderlich, John, Mishell, Robert

Two classes of 7S γ-globulins are identified in normal mouse serum and are designated 7S γ2-globulins and 7S γ1-globulins. These two immunoglobulin classes are similar in size. They differ in...

THE IMMUNOGLOBULINS OF MICE : II. TWO SUBCLASSES OF MOUSE 7S γ2-GLOBULINS: γ2a-ANDγ2b-GLOBULINS

Fahey, John L., Wunderlich, John, Mishell, Robert

Two subclasses of mouse 7S γ2-globulins are identified, and are designated γ2a- and γ2b-globulins. They are distinguished from 7S γ1-globulins, γ1A (β2A)-globulins, and γ1M-globulins of mouse...

A NEW CLASS OF HUMAN IMMUNOGLOBULINS : II. NORMAL SERUM IGD

Rowe, David S., Fahey, John L.

A new class of immunoglobulin, IgD, was identified in normal human serum by immunochemical technics. Antiserums prepared against the unique S.J. myeloma protein facilitated recognition of the related...

A NEW CLASS OF HUMAN IMMUNOGLOBULINS : I. A UNIQUE MYELOMA PROTEIN

Rowe, David S., Fahey, John L.

The unique myeloma protein from S. J., a patient with multiple myeloma, was isolated and characterized. It resembled other myeloma proteins in many respects. The S. J. myeloma protein migrated in a...

THE IMMUNOGLOBULINS OF MICE : V. THE METABOLIC (CATABOLIC) PROPERTIES OF FIVE IMMUNOGLOBULIN CLASSES

Fahey, John L., Sell, Stewart

The metabolic properties of immunoglobulin were investigated by comparing five classes of mouse immunoglobulin. Three forms of 7S immunoglobulin had different rates of catabolism. The fractional...

GM AND INV FACTORS IN SUBCLASSES OF HUMAN IGG

Terry, William D., Fahey, John L., Steinberg, Arthur G.

Human G myeloma (7S γ2-myeloma) proteins were investigated for relationships between Gm and Inv genetic factors and the different antigenic types of heavy polypeptide chains (γ-chains) and light...

Knowledge and Attitudes about HIV/AIDS among Homoeopathic Practitioners and Educators in India

Nyamathi, Adeline, Singh, Vijay Pal, Lowe, Ann, Khurana, Anil, Taneja, Divya, George, Sheba, ...

This study is designed to assess AIDS knowledge among Homeopathy educators and physicians in India, which has not been evaluated previously. India now has the largest number of HIV infected persons...