John Hesketh

Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender-specific manner the SELGEN study (2007)

Prof. John Hesketh, Prof. John Cummings Mathers

Evidence that a polymorphism within the 3UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer. (2007)

Prof. John Hesketh, Prof. John Cummings Mathers

Elongation factor 1945 binds to the region of the metallothionein-1 mRNA implicated in perinuclear localizationimportance of an internal stemloop (2006)

Prof. John Hesketh

Annexin A2 binds to the localization signal in the 38242 untranslated region of ic-myci mRNA (2005)

Prof. John Hesketh

An AU-rich stemloop structure is a critical feature of the perinuclear localization signal of ic-myci mRNA (2005)

Prof. John Hesketh

mRNA Localization by a 145-Nucleotide Region of the ic-fosi 38242- Untranslated Region LINKS TO TRANSLATION BUT NOT STABILITY (2001)

Prof. John Hesketh

An eleven nucleotide section of the 3′-untranslated region is required for perinuclear localization of rat metallothionein-1 mRNA

Nury, David, Chabanon, Hervé, Levadoux-Martin, Marilyne, Hesketh, John

Localization of mRNAs provides a novel mechanism for synthesis of proteins close to their site of function. MT1 (metallothionein-1) is a small, metal-binding protein that is largely cytoplasmic but...

An AU-rich stem–loop structure is a critical feature of the perinuclear localization signal of c-myc mRNA

Chabanon, Hervé, Mickleburgh, Ian, Burtle, Brian, Pedder, Christopher, Hesketh, John

In eukaryotic cells, several mRNAs including those of c-myc and c-fos are localized to the perinuclear cytoplasm and associated with the cytoskeleton. The localization element of c-myc mRNA is...

An eleven nucleotide section of the 3′-untranslated region is required for perinuclear localization of rat metallothionein-1 mRNA

Nury, David, Chabanon, Hervé, Levadoux-Martin, Marilyne, Hesketh, John

Localization of mRNAs provides a novel mechanism for synthesis of proteins close to their site of function. MT1 (metallothionein-1) is a small, metal-binding protein that is largely cytoplasmic but...

An AU-rich stem–loop structure is a critical feature of the perinuclear localization signal of c-myc mRNA

Chabanon, Hervé, Mickleburgh, Ian, Burtle, Brian, Pedder, Christopher, Hesketh, John

In eukaryotic cells, several mRNAs including those of c-myc and c-fos are localized to the perinuclear cytoplasm and associated with the cytoskeleton. The localization element of c-myc mRNA is...

Elongation factor 1α binds to the region of the metallothionein-1 mRNA implicated in perinuclear localization—importance of an internal stem–loop

Mickleburgh, Ian, Chabanon, Hervé, Nury, David, Fan, Kunbo, Burtle, Brian, Chrzanowska-Lightowlers, Zofia, ...

In eukaryotic cells, mRNA localization can provide local protein synthesis. Metallothionein-1 (MT-1) mRNA is associated with the perinuclear cytoskeleton, and this is essential for subsequent nuclear...

The challenges for molecular nutrition research 1: linking genotype to healthy nutrition

Williams, Christine M., Ordovas, Jose M., Lairon, Dennis, Hesketh, John, Lietz, Georg, Gibney, Mike, ...

Nutrition science finds itself at a major crossroad. On the one hand we can continue the current path, which has resulted in some substantial advances, but also many conflicting messages which impair...