Gastrointestinal dysfunction in the critically ill: can we measure it? (2008)
Khadaroo, Rachel G, Marshall, John C
Abstract Gastrointestinal dysfunction is an intuitively important, yet descriptively elusive component of the multiple organ dysfunction syndrome. Reintam and colleagues have attempted to quantify...
Surviving sepsis: a guide to the guidelines (2008)
Vincent, Jean-Louis, Marshall, John C
Abstract The revised Surviving Sepsis Campaign (SSC) guidelines for the management of severe sepsis and septic shock have recently been published. These guidelines represent the end product of an...
Iatrogenesis, inflammation and organ injury: insights from a murine model (2006)
Abstract The complex biology of critical illness not only reflects the initial insult that brought the patient to the intensive care unit but also, and perhaps even more importantly, it reflects the...
The staging of sepsis: understanding heterogeneity in treatment efficacy (2005)
Abstract Human sepsis is an intrinsically complex disease. Populations of patients enrolled into clinical trials of novel sepsis therapies are notoriously heterogeneous with respect to the inciting...
Transfusion trigger: when to transfuse? (2004)
Abstract The decision to transfuse a hospitalized patient must balance the known risks of transfusion with the need to provide adequate tissue oxygenation and the appropriate utilization of blood as...
Kathleen A. Prendergast, Laura L. Burger, Kevin W. Aylor, Daniel J. Haisenleder, Alan C. Dalkin, John C. Marshall
Follistatin (FS), along with the members of the transforming growth factor β family activin and inhibin, are important regulators of FSH secretion and messenger RNA production. While activin and...
Measurements in the intensive care unit: what do they mean? (2003)
Abstract Intensivists depend upon a large number of measurements to make daily decisions in the ICU. However, the reliability of these measures may be jeopardized by the effects of therapy. Moreover,...
The PIRO Concept: R is for response (2003)
Gerlach, Herwig, Dhainaut, Jean-Francois, Harbarth, Stephan, Reinhart, Konrad, Marshall, John C, Levy, Mitchell
No abstract available.
The PIRO Concept: O is for organ dysfunction (2003)
Vincent, Jean-Louis, Wendon, Julia, Groeneveld, Johan, Marshall, John C, Streat, Stephen, Carlet, Jean
No abstract available.
Fink, Gereon R., Marshall, John C., Weiss, Peter H., Stephan, Thomas, Grefkes, Christian, Shah, Nadim J., ...
The International Sepsis Forum's controversies in sepsis: how will sepsis be treated in 2051? (2002)
Abstract Sepsis, the life-threatening illness that arises from innate immunity to overwhelming infection, is treated symptomatically at the start of the 21st century. Looking ahead 50 years, one can...
Marshall, John C, Walker, Paul M, Foster, Debra M, Harris, David, Ribeiro, Melanie, Paice, Jeff, ...
Abstract Background Lipopolysaccharide (endotoxin) from the cell wall of Gram-negative bacteria is a potent trigger for the release of host-derived inflammatory mediators. The relationship between...
An Evaluative Review of Hemispheric Learning Potential. (2002)
Davidoff,Jules, Marshall,John C., Beaumont,J. G., Beaton,Alan
This report reviews evidence from several sources that conclusively shows the two hemispheres of the human brain have different functional organizations for cognition. The notion of...
Consciousness: Or attempts to find the machine in the ghost (2000)
No abstract available.
Modelling Studies in Support of Open-Ocean Convection Field Programs. (1998)
We have begun an inquiry into the process of open-ocean deep convection guided by the field observations collected in the western Mediterranean during the past winter. Our goals are to understand the...
The End of the Line for a Brain-Damaged Model of Unilateral Neglect (1997)
Michael C. Mozer, Peter W. Halligan, John C. Marshall
For over a century, it has been known that damage to the right hemisphere of the brain can cause patients to be unaware of the contralesional side of space. This condition, known as unilateral...
Reame, Nancy E., Marshall, John C., Kelch, Robert P.
The premenstrual syndrome (PMS) has been proposed to result from excessive exposure to and/or withdrawal of brain opioid activity during the luteal phase. Because hypothalamic opioids are believed to...
Haisenleder, DJ, Ortolano, GA, Jolly, D, Dalkin, AC, Landefeld, Thomas D., Vale, Wylie W., ...
Serum inhibin and FSH and FSH beta subunit mRNA levels were measured at 3h intervals throughout the 4 day estrous cycle in female rats and hourly between 1000 and 2400 h of proestrus. On proestrus,...
The role of the suckling stimulus in regulating pituitary prolactin mRNA in the rat (1989)
Lee, Ling Ru, Haisenleder, Daniel J., Marshall, John C., Smith, M. Susan
Prolactin (PRL) gene expression and the synthesis and secretion of PRL were examined in ovarian-intact lactating rats suckling eight pups on 10 days postpartum. Plasma samples were assayed for PRL...
Pituitary localization of 3H-spiroperidol by an Uptake/Storage Mechanism? (1986)
Otto, Charlotte A., Sherman, Phillip S., Fisher, Susan J., Valoppi, Valeri L., Marshall, John C., Lloyd, Ricardo V., ...
The lack of a pituitary imaging agent combined with the considerable clinical value for such an agent prompted an examination of 3H-spiroperidol (3HSp). Spiroperidol was selected for initial...
Use of DES-treated rats as an animal model for assessment of pituitary adenoma imaging agents (1986)
Otto, Charlotte A., Marshall, John C., Lloyd, Ricardo V., Sherman, Phillip S., Fisher, Susan J., Valoppi, Valeri L., ...
Prolactin (PRL) secreting pituitary adenomas are the most common type of pituitary tumors. An imaging agent which specifically localized in prolactinomas would be of considerable clinical value for...
Savoy-Moore, Ruth T., Landefeld, Thomas D., Marshall, John C.
Immunoassayable LH in media samples from rat anterior pituitary cell cultures declines during storage and only 20% of the LH remains after 4 weeks at -20[deg]C. The LH loss was not due to bacterial...
Marshall, John C, Walker, Paul M, Foster, Debra M, Harris, David, Ribeiro, Melanie, Paice, Jeff, ...
The International Sepsis Forum's controversies in sepsis: how will sepsis be treated in 2051?
Sepsis, the life-threatening illness that arises from innate immunity to overwhelming infection, is treated symptomatically at the start of the 21st century. Looking ahead 50 years, one can perhaps...
The PIRO Concept: R is for response
Gerlach, Herwig, Dhainaut, Jean-Francois, Harbarth, Stephan, Reinhart, Konrad, Marshall, John C, Levy, Mitchell
The PIRO Concept: O is for organ dysfunction
Vincent, Jean-Louis, Wendon, Julia, Groeneveld, Johan, Marshall, John C, Streat, Stephen, Carlet, Jean
Measurements in the intensive care unit: what do they mean?
Intensivists depend upon a large number of measurements to make daily decisions in the ICU. However, the reliability of these measures may be jeopardized by the effects of therapy. Moreover, in...
Jia, Song Hui, Li, Yue, Parodo, Jean, Kapus, Andras, Fan, Lingzhi, Rotstein, Ori D., ...
Pre–B cell colony-enhancing factor (PBEF) is a highly conserved 52-kDa protein, originally identified as a growth factor for early stage B cells. We show here that PBEF is also upregulated in...
The Spectrum of Pituitary Adenoma Hemorrhage
Hickstein, Dennis D., Marshall, John C., Chandler, William F.
In 34 cases of pituitary adenoma hemorrhage at one institution, the clinical manifestations of adenoma hemorrhage depended upon the size of the adenoma, the presence of suprasellar extension, the...
The staging of sepsis: understanding heterogeneity in treatment efficacy
Human sepsis is an intrinsically complex disease. Populations of patients enrolled into clinical trials of novel sepsis therapies are notoriously heterogeneous with respect to the inciting cause of...
McLeod, Robin S., Geerts, William H., Sniderman, Kenneth W., Greenwood, Celia, Gregoire, Roger C., Taylor, Brian M., ...
Marshall, John C, Walker, Paul M, Foster, Debra M, Harris, David, Ribeiro, Melanie, Paice, Jeff, ...
The International Sepsis Forum's controversies in sepsis: how will sepsis be treated in 2051?
Sepsis, the life-threatening illness that arises from innate immunity to overwhelming infection, is treated symptomatically at the start of the 21st century. Looking ahead 50 years, one can perhaps...
The PIRO Concept: R is for response
Gerlach, Herwig, Dhainaut, Jean-Francois, Harbarth, Stephan, Reinhart, Konrad, Marshall, John C, Levy, Mitchell
The PIRO Concept: O is for organ dysfunction
Vincent, Jean-Louis, Wendon, Julia, Groeneveld, Johan, Marshall, John C, Streat, Stephen, Carlet, Jean
Measurements in the intensive care unit: what do they mean?
Intensivists depend upon a large number of measurements to make daily decisions in the ICU. However, the reliability of these measures may be jeopardized by the effects of therapy. Moreover, in...
Jia, Song Hui, Li, Yue, Parodo, Jean, Kapus, Andras, Fan, Lingzhi, Rotstein, Ori D., ...
Pre–B cell colony-enhancing factor (PBEF) is a highly conserved 52-kDa protein, originally identified as a growth factor for early stage B cells. We show here that PBEF is also upregulated in...
The Spectrum of Pituitary Adenoma Hemorrhage
Hickstein, Dennis D., Marshall, John C., Chandler, William F.
In 34 cases of pituitary adenoma hemorrhage at one institution, the clinical manifestations of adenoma hemorrhage depended upon the size of the adenoma, the presence of suprasellar extension, the...
The staging of sepsis: understanding heterogeneity in treatment efficacy
Human sepsis is an intrinsically complex disease. Populations of patients enrolled into clinical trials of novel sepsis therapies are notoriously heterogeneous with respect to the inciting cause of...
McLeod, Robin S., Geerts, William H., Sniderman, Kenneth W., Greenwood, Celia, Gregoire, Roger C., Taylor, Brian M., ...
Iatrogenesis, inflammation and organ injury: insights from a murine model
The complex biology of critical illness not only reflects the initial insult that brought the patient to the intensive care unit but also, and perhaps even more importantly, it reflects the...
Powers, Kinga A., Szászi, Katalin, Khadaroo, Rachel G., Tawadros, Patrick S., Marshall, John C., Kapus, András, ...
Oxidative stress generated by ischemia/reperfusion is known to prime inflammatory cells for increased responsiveness to subsequent stimuli, such as lipopolysaccharide (LPS). The mechanism(s)...
Human Torture: Description and Sequelae of 104 Cases
Domovitch, Edward, Berger, Philip B., Wawer, Maria J., Etlin, David D., Marshall, John C.
We examined 104 torture victims, 99 of whom were from Chile. Most of our patients were young men who had been arrested for political reasons. All the patients had been beaten; other common methods of...
Pension fund trustee competence: decision making in problems relevant to investment practice
CLARK, GORDON L., CAERLEWY-SMITH, EMIKO, MARSHALL, JOHN C.
Government-sponsored inquiries into trustee competence, and legislation regarding the protocols and practice of trustee decision making, have raised questions about the competence of trustees to make...
The consistency of UK pension fund trustee decision-making
CLARK, GORDON L., CAERLEWY-SMITH, EMIKO, MARSHALL, JOHN C.
An important research programme in the social sciences concerns the theory and practice of individual decision-making under conditions of risk and uncertainty. At the same time, it is apparent that...
Surviving sepsis: a guide to the guidelines
Vincent, Jean-Louis, Marshall, John C
The revised Surviving Sepsis Campaign (SSC) guidelines for the management of severe sepsis and septic shock have recently been published. These guidelines represent the end product of an intense...