Ferguson, Andrew D., Labunskyy , Vyacheslav, Fomenko, Dmitri E., Arac, Demet, Chelliah, Yogarany, Amexcua, Carlos A., ...
Selenium has significant health benefits, including potent cancer prevention activity and roles in immune function and the male reproductive system. Selenium-containing proteins, which incorporate...
Chung-I Chang, Sébastien Pili-Floury, Mireille Hervé, Claudine Parquet, Yogarany Chelliah, Bruno Lemaitre, ...
The Drosophila protein PGRP-SA is found to have an intrinsic activity to cleave L,D-configured peptide bonds, which exist only in prokaryotes. This work reveals a rare enzymatic activity in a...
Chung-I Chang, Sébastien Pili-Floury, Mireille Hervé, Claudine Parquet, Yogarany Chelliah, Bruno Lemaitre, ...
The Drosophila peptidoglycan recognition protein SA (PGRP-SA) is critically involved in sensing bacterial infection and activating the Toll signaling pathway, which induces the expression of specific...
Structure of the LDL receptor extracellular domain at endosomal pH (2002)
Rudenko, Gabby, Henry, Lisa, Henderson, Keith, Ichtchenko, Konstantin, Brown, Michael S., Goldstein, Joseph L., ...
The structure of the low-density lipoprotein receptor extracellular portion has been determined. The document proposes a mechanism for the release of lipoprotein in the endosome. Without this...
Crystal structure of the DNA nucleotide excision repair enzyme UvrB from Thermus thermophilus
Machius, Mischa, Henry, Lisa, Palnitkar, Maya, Deisenhofer, Johann
Nucleotide excision repair (NER) is the most important DNA-repair mechanism in living organisms. In prokaryotes, three enzymes forming the UvrABC system initiate NER of a variety of structurally...
Kim, Hoeon, Xia, Di, Yu, Chang-An, Xia, Jia-Zhi, Kachurin, Anatoly M., Zhang, Li, ...
We have analyzed crystal structures of cytochrome bc1 complexes with electron transfer inhibitors bound to the ubiquinone binding pockets Qi and/or Qo in the cytochrome b subunit. The presence or...
Usher, Ken C., Özkan, Engin, Gardner, Kevin H., Deisenhofer, Johann
FepA, an outer membrane iron siderophore transporter from Escherichia coli, is composed of a 22-stranded membrane-spanning β barrel with a globular N-terminal “plug” domain of 148 residues that...
Tang, Zhanyun, Li, Bing, Bharadwaj, Rajnish, Zhu, Haizhen, Özkan, Engin, Hakala, Kevin, ...
In mitosis, the anaphase-promoting complex (APC) regulates the onset of sister-chromatid separation and exit from mitosis by mediating the ubiquitination and degradation of the securin protein and...
Dann, Charles E., Bruick, Richard K., Deisenhofer, Johann
Precise regulation of the evolutionarily conserved hypoxia-inducible transcription factor (HIF) ensures proper adaptation to variations in oxygen availability throughout development and into...
Istvan, Eva S., Palnitkar, Maya, Buchanan, Susan K., Deisenhofer, Johann
3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) catalyzes the formation of mevalonate, the committed step in the biosynthesis of sterols and isoprenoids. The activity of HMGR is controlled through...
Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana
Brautigam, Chad A., Smith, Barbara S., Ma, Zhiquan, Palnitkar, Maya, Tomchick, Diana R., Machius, Mischa, ...
Signals generated by cryptochrome (CRY) blue-light photoreceptors are responsible for a variety of developmental and circadian responses in plants. The CRYs are also identified as circadian...
Chang, Chung-I, Pili-Floury, Sébastien, Hervé, Mireille, Parquet, Claudine, Chelliah, Yogarany, Lemaitre, Bruno, ...
The Drosophila peptidoglycan recognition protein SA (PGRP-SA) is critically involved in sensing bacterial infection and activating the Toll signaling pathway, which induces the expression of specific...
Chang, Chung-I, Ihara, Kentaro, Chelliah, Yogarany, Mengin-Lecreulx, Dominique, Wakatsuki, Soichi, Deisenhofer, Johann
The peptidoglycan-recognition protein LCa (PGRP-LCa) is a transmembrane receptor required for activation of the Drosophila immune deficiency pathway by monomeric Gram-negative peptidoglycan. We have...
Özkan, Engin, Yu, Hongtao, Deisenhofer, Johann
Ubiquitin-conjugating enzymes (E2s) collaborate with the ubiquitin-activating enzyme (E1) and ubiquitin ligases (E3s) to attach ubiquitin to target proteins. RING-containing E3s simultaneously bind...
Colbert, Christopher L., Wu, Qiong, Erbel, Paul J. A., Gardner, Kevin H., Deisenhofer, Johann
The covalent attachment of heme cofactors to the apo-polypeptides via thioether bonds is unique to the maturation of c-type cytochromes. A number of thiol-disulfide oxidoreductases prepare the...
Crystal structure of the DNA nucleotide excision repair enzyme UvrB from Thermus thermophilus
Machius, Mischa, Henry, Lisa, Palnitkar, Maya, Deisenhofer, Johann
Nucleotide excision repair (NER) is the most important DNA-repair mechanism in living organisms. In prokaryotes, three enzymes forming the UvrABC system initiate NER of a variety of structurally...
Kim, Hoeon, Xia, Di, Yu, Chang-An, Xia, Jia-Zhi, Kachurin, Anatoly M., Zhang, Li, ...
We have analyzed crystal structures of cytochrome bc1 complexes with electron transfer inhibitors bound to the ubiquinone binding pockets Qi and/or Qo in the cytochrome b subunit. The presence or...
Usher, Ken C., Özkan, Engin, Gardner, Kevin H., Deisenhofer, Johann
FepA, an outer membrane iron siderophore transporter from Escherichia coli, is composed of a 22-stranded membrane-spanning β barrel with a globular N-terminal “plug” domain of 148 residues that...
Tang, Zhanyun, Li, Bing, Bharadwaj, Rajnish, Zhu, Haizhen, Özkan, Engin, Hakala, Kevin, ...
In mitosis, the anaphase-promoting complex (APC) regulates the onset of sister-chromatid separation and exit from mitosis by mediating the ubiquitination and degradation of the securin protein and...
Dann, Charles E., Bruick, Richard K., Deisenhofer, Johann
Precise regulation of the evolutionarily conserved hypoxia-inducible transcription factor (HIF) ensures proper adaptation to variations in oxygen availability throughout development and into...
Istvan, Eva S., Palnitkar, Maya, Buchanan, Susan K., Deisenhofer, Johann
3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) catalyzes the formation of mevalonate, the committed step in the biosynthesis of sterols and isoprenoids. The activity of HMGR is controlled through...
Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana
Brautigam, Chad A., Smith, Barbara S., Ma, Zhiquan, Palnitkar, Maya, Tomchick, Diana R., Machius, Mischa, ...
Signals generated by cryptochrome (CRY) blue-light photoreceptors are responsible for a variety of developmental and circadian responses in plants. The CRYs are also identified as circadian...
Chang, Chung-I, Pili-Floury, Sébastien, Hervé, Mireille, Parquet, Claudine, Chelliah, Yogarany, Lemaitre, Bruno, ...
The Drosophila peptidoglycan recognition protein SA (PGRP-SA) is critically involved in sensing bacterial infection and activating the Toll signaling pathway, which induces the expression of specific...
Chang, Chung-I, Ihara, Kentaro, Chelliah, Yogarany, Mengin-Lecreulx, Dominique, Wakatsuki, Soichi, Deisenhofer, Johann
The peptidoglycan-recognition protein LCa (PGRP-LCa) is a transmembrane receptor required for activation of the Drosophila immune deficiency pathway by monomeric Gram-negative peptidoglycan. We have...
Özkan, Engin, Yu, Hongtao, Deisenhofer, Johann
Ubiquitin-conjugating enzymes (E2s) collaborate with the ubiquitin-activating enzyme (E1) and ubiquitin ligases (E3s) to attach ubiquitin to target proteins. RING-containing E3s simultaneously bind...
Colbert, Christopher L., Wu, Qiong, Erbel, Paul J. A., Gardner, Kevin H., Deisenhofer, Johann
The covalent attachment of heme cofactors to the apo-polypeptides via thioether bonds is unique to the maturation of c-type cytochromes. A number of thiol-disulfide oxidoreductases prepare the...
Huang, Yihua, Baxter, Richard, Smith, Barbara S., Partch, Carrie L., Colbert, Christopher L., Deisenhofer, Johann
Cryptochromes use near-UV/blue light to regulate a variety of growth and adaptive process. Recent biochemical studies demonstrate that the Cryptochrome-Drosophila, Arabidopsis, Synechocystis, Human...
Signal transduction pathway of TonB-dependent transporters
Ferguson, Andrew D., Amezcua, Carlos A., Halabi, Najeeb M., Chelliah, Yogarany, Rosen, Michael K., Ranganathan, Rama, ...
Transcription of the ferric citrate import system is regulated by ferric citrate binding to the outer membrane transporter FecA. A signal indicating transporter occupancy is relayed across the outer...
Structural basis for conserved complement factor-like function in the antimalarial protein TEP1
Baxter, Richard H. G., Chang, Chung-I, Chelliah, Yogarany, Blandin, Stéphanie, Levashina, Elena A., Deisenhofer, Johann
Thioester-containing proteins (TEPs) are a major component of the innate immune response of insects to invasion by bacteria and protozoa. TEPs form a distinct clade of a superfamily that includes the...
Molecular basis for LDL receptor recognition by PCSK9
Kwon, Hyock Joo, Lagace, Thomas A., McNutt, Markey C., Horton, Jay D., Deisenhofer, Johann
Proprotein convertase subtilisin/kexin type 9 (PCSK9) posttranslationally regulates hepatic low-density lipoprotein receptors (LDLRs) by binding to LDLRs on the cell surface, leading to their...