Rosenstiel, Philip, Huse, Klaus, Franke, Andre, Hampe, Jochen, Reichwald, Kathrin, Platzer, Cornelia, ...
Abstract Background NOD2 is an innate immune receptor for the bacterial cell wall component muramyl-dipeptide. Mutations in the leucine-rich repeat region of NOD2, which lead to an impaired...
Predictors of gallstone composition in 1025 symptomatic gallstones from Northern Germany (2006)
Schafmayer, Clemens, Hartleb, Jürgen, Tepel, Jürgen, Albers, Stefan, Freitag, Sandra, Völzke, Henry, ...
Abstract Background Gallstones represent a prevalent and costly health problem. The changing epidemiology and the emerging non-surgical interventions for gallstone disease necessitate the definition...
Elder, James T., Nair, Rajan, Kabelitz, Dietrich, Stuart, Philip, Schreiber, Stefan, Voorhees, John J., ...
Psoriasis has a strong genetic component in the development of the disease as indicated by familial occurrence and a high concordance rate among monozygotic twins. In genome-wide scans for psoriasis...
Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays (2005)
Christine M. Costello, Nancy Mah, Robert Häsler, Philip Rosenstiel, Georg H. Waetzig, Andreas Hahn, ...
cDNA analysis of colonic samples from patients with Crohn disease and ulcerative colitis suggests substantial differences in pathophysiology between the two diseases.
Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays (2005)
Christine M. Costello, Nancy Mah, Robert Häsler, Philip Rosenstiel, Georg H. Waetzig, Andreas Hahn, ...
Background The differential pathophysiologic mechanisms that trigger and maintain the two forms of inflammatory bowel disease (IBD), Crohn disease (CD), and ulcerative colitis (UC) are only partially...
Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays (2005)
Costello, Christine M., Mah, Nancy, Häsler, Robert, Rosenstiel, Philip, Waetzig, Georg H., Hahn, Andreas, ...
Background The differential pathophysiologic mechanisms that trigger and maintain the two forms of inflammatory bowel disease (IBD), Crohn disease (CD), and ulcerative colitis (UC) are only partially...
Genetic variation in DLG5 is associated with inflammatory bowel disease (2004)
Stoll,Monika, Corneliussen,Brit, Costello,Christine M., Waetzig,Georg H., Mellgard,Bjorn, Koch,W. Andreas, ...
Genetic variation in DLG5 is associated with inflammatory bowel disease (2004)
Stoll, Monika, Corneliussen, Brit, Costello, Christine M., Waetzig, Georg H., Mellgard, Bjorn, Koch, W. Andreas, ...
Tümer,Zeynep, Croucher,Peter J. P., Jensen,Lars Riff, Hampe,Jochen, Hansen,Claus, Kalscheuer,Vera, ...
Chronic inflammatory bowel disease is a multifactorial disorder with two major clinical forms, Crohn's disease and ulcerative colitis. One of the potential susceptibility loci for inflammatory bowel...
Tümer, Zeynep, Croucher, Peter J. P., Jensen, Lars Riff, Hampe, Jochen, Hansen, Claus, Kalscheuer, Vera, ...
Chronic inflammatory bowel disease is a multifactorial disorder with two major clinical forms, Crohn's disease and ulcerative colitis. One of the potential susceptibility loci for inflammatory bowel...
Hampe,Jochen, Frenzel,Henning, Mirza,Muddassar M., Croucher,Peter J. P., Cuthbert,Andrew, Mascheretti,Silvia, ...
Heritable predisposition to inflammatory bowel disease (IBD) has been demonstrated by epidemiological and genetic analysis. Linkage of IBD to broad regions of chromosome 16 has been established by...
Hampe, Jochen, Frenzel, Henning, Mirza, Muddassar M., Croucher, Peter J. P., Cuthbert, Andrew, Mascheretti, Silvia, ...
Heritable predisposition to inflammatory bowel disease (IBD) has been demonstrated by epidemiological and genetic analysis. Linkage of IBD to broad regions of chromosome 16 has been established by...
Berlin, Humboldt-Univ., Diss., 1996.
Hampe, Jochen, Frenzel, Henning, Mirza, Muddassar M., Croucher, Peter J. P., Cuthbert, Andrew, Mascheretti, Silvia, ...
Heritable predisposition to inflammatory bowel disease (IBD) has been demonstrated by epidemiological and genetic analysis. Linkage of IBD to broad regions of chromosome 16 has been established by...
Ott, Stephan J., Musfeldt, Meike, Ullmann, Uwe, Hampe, Jochen, Schreiber, Stefan
The composition of the human intestinal flora is important for the health status of the host. The global composition and the presence of specific pathogens are relevant to the effects of the flora....
Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays
Costello, Christine M, Mah, Nancy, Häsler, Robert, Rosenstiel, Philip, Waetzig, Georg H, Hahn, Andreas, ...
cDNA analysis of colonic samples from patients with Crohn disease and ulcerative colitis suggests substantial differences in pathophysiology between the two diseases.
Linkage of Inflammatory Bowel Disease to Human Chromosome 6p
Hampe, Jochen, Shaw, Sarah H., Saiz, Robert, Leysens, Nancy, Lantermann, Annette, Mascheretti, Silvia, ...
Inflammatory bowel disease (IBD) is characterized by a chronic relapsing intestinal inflammation. IBD is subdivided into Crohn disease and ulcerative colitis phenotypes. Given the immunologic...
Hiller, Michael, Huse, Klaus, Szafranski, Karol, Jahn, Niels, Hampe, Jochen, Schreiber, Stefan, ...
Aberrant or modified splicing patterns of genes are causative for many human diseases. Therefore, the identification of genetic variations that cause changes in the splicing pattern of a gene is...
Rosenstiel, Philip, Huse, Klaus, Till, Andreas, Hampe, Jochen, Hellmig, Stephan, Sina, Christian, ...
Alterations in splicing patterns of genes contribute to the regulation of gene function by generating endogenous inhibitor or activator molecules. Nucleotide-binding and oligomerization domain (NOD)...
Predictors of gallstone composition in 1025 symptomatic gallstones from Northern Germany
Schafmayer, Clemens, Hartleb, Jürgen, Tepel, Jürgen, Albers, Stefan, Freitag, Sandra, Völzke, Henry, ...
Hampe, Jochen, Frenzel, Henning, Mirza, Muddassar M., Croucher, Peter J. P., Cuthbert, Andrew, Mascheretti, Silvia, ...
Heritable predisposition to inflammatory bowel disease (IBD) has been demonstrated by epidemiological and genetic analysis. Linkage of IBD to broad regions of chromosome 16 has been established by...
Ott, Stephan J., Musfeldt, Meike, Ullmann, Uwe, Hampe, Jochen, Schreiber, Stefan
The composition of the human intestinal flora is important for the health status of the host. The global composition and the presence of specific pathogens are relevant to the effects of the flora....
Genetic Evidence for Interaction of the 5q31 Cytokine Locus and the CARD15 Gene in Crohn Disease
Mirza, Muddassar M., Fisher, Sheila A., King, Kathy, Cuthbert, Andrew P., Hampe, Jochen, Sanderson, Jeremy, ...
A common haplotype spanning 250 kb in the cytokine gene cluster on chromosome 5q31 has recently been reported to be strongly associated with Crohn disease (CD) in Canadian families. We have...
Giallourakis, Cosmas, Stoll, Monika, Miller, Katie, Hampe, Jochen, Lander, Eric S., Daly, Mark J., ...
Inflammatory bowel disease (IBD) refers to complex chronic relapsing autoimmune disorders of the gastrointestinal tract that have been traditionally classified into Crohn disease (CD) and ulcerative...
Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays
Costello, Christine M, Mah, Nancy, Häsler, Robert, Rosenstiel, Philip, Waetzig, Georg H, Hahn, Andreas, ...
cDNA analysis of colonic samples from patients with Crohn disease and ulcerative colitis suggests substantial differences in pathophysiology between the two diseases.
Hillmer, Axel M., Hanneken, Sandra, Ritzmann, Sibylle, Becker, Tim, Freudenberg, Jan, Brockschmidt, Felix F., ...
Androgenetic alopecia (AGA), or male-pattern baldness, is the most common form of hair loss. Its pathogenesis is androgen dependent, and genetic predisposition is the major requirement for the...
Linkage of Inflammatory Bowel Disease to Human Chromosome 6p
Hampe, Jochen, Shaw, Sarah H., Saiz, Robert, Leysens, Nancy, Lantermann, Annette, Mascheretti, Silvia, ...
Inflammatory bowel disease (IBD) is characterized by a chronic relapsing intestinal inflammation. IBD is subdivided into Crohn disease and ulcerative colitis phenotypes. Given the immunologic...
Hiller, Michael, Huse, Klaus, Szafranski, Karol, Jahn, Niels, Hampe, Jochen, Schreiber, Stefan, ...
Aberrant or modified splicing patterns of genes are causative for many human diseases. Therefore, the identification of genetic variations that cause changes in the splicing pattern of a gene is...
Rosenstiel, Philip, Huse, Klaus, Till, Andreas, Hampe, Jochen, Hellmig, Stephan, Sina, Christian, ...
Alterations in splicing patterns of genes contribute to the regulation of gene function by generating endogenous inhibitor or activator molecules. Nucleotide-binding and oligomerization domain (NOD)...
Predictors of gallstone composition in 1025 symptomatic gallstones from Northern Germany
Schafmayer, Clemens, Hartleb, Jürgen, Tepel, Jürgen, Albers, Stefan, Freitag, Sandra, Völzke, Henry, ...
Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene
Franke, Andre, Hampe, Jochen, Rosenstiel, Philip, Becker, Christian, Wagner, Florian, Häsler, Robert, ...
Crohn disease (CD), a sub-entity of inflammatory bowel disease (IBD), is a complex polygenic disorder. Although recent studies have successfully identified CD-associated genetic variants, these...
Efficacy assessment of SNP sets for genome-wide disease association studies
Wollstein, Andreas, Herrmann, Alexander, Wittig, Michael, Nothnagel, Michael, Franke, Andre, Nürnberg, Peter, ...
The power of a genome-wide disease association study depends critically upon the properties of the marker set used, particularly the number and physical spacing of markers, and the level of...