Joanne Higgins

Virulence and Reduced Fitness of Simian Immunodeficiency Virus with the M184V Mutation in Reverse Transcriptase

Van Rompay, Koen K. A., Matthews, Tim B., Higgins, Joanne, Canfield, Don R., Tarara, Ross P., Wainberg, Mark A., ...

Drug-resistant mutants with a methionine-to-valine substitution at position 184 of reverse transcriptase (M184V) emerged within 5 weeks of initiation of therapy in four newborn macaques infected with...

Reversion of the M184V Mutation in Simian Immunodeficiency Virus Reverse Transcriptase Is Selected by Tenofovir, Even in the Presence of Lamivudine

Murry, Jeffrey P., Higgins, Joanne, Matthews, Timothy B., Huang, Victoria Y., Van Rompay, Koen K. A., Pedersen, Niels C., ...

The methionine-to-valine mutation in codon 184 (M184V) in reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) or simian immunodeficiency virus (SIV) confers resistance to...

Susceptibilities of Simian Immunodeficiency Virus to Protease Inhibitors

Giuffre, Angelica C., Higgins, Joanne, Buckheit Jr., Robert W., North, Thomas W.

We used a focal infectivity assay with HeLa H1-JC.37 cells to directly compare susceptibilities of simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) to protease...

Efavirenz Therapy in Rhesus Macaques Infected with a Chimera of Simian Immunodeficiency Virus Containing Reverse Transcriptase from Human Immunodeficiency Virus Type 1

Hofman, Michael J., Higgins, Joanne, Matthews, Timothy B., Pedersen, Niels C., Tan, Chalet, Schinazi, Raymond F., ...

The specificity of nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) for the RT of human immunodeficiency virus type 1 (HIV-1) has prevented the use of simian immunodeficiency virus (SIV)...

Suppression of Virus Load by Highly Active Antiretroviral Therapy in Rhesus Macaques Infected with a Recombinant Simian Immunodeficiency Virus Containing Reverse Transcriptase from Human Immunodeficiency Virus Type 1

North, Thomas W., Van Rompay, Koen K. A., Higgins, Joanne, Matthews, Timothy B., Wadford, Debra A., Pedersen, Niels C., ...

We have modeled highly active antiretroviral therapy (HAART) for AIDS in rhesus macaques infected with a chimera (RT-SHIV) of simian immunodeficiency virus containing reverse transcriptase from human...

Virulence and Reduced Fitness of Simian Immunodeficiency Virus with the M184V Mutation in Reverse Transcriptase

Van Rompay, Koen K. A., Matthews, Tim B., Higgins, Joanne, Canfield, Don R., Tarara, Ross P., Wainberg, Mark A., ...

Drug-resistant mutants with a methionine-to-valine substitution at position 184 of reverse transcriptase (M184V) emerged within 5 weeks of initiation of therapy in four newborn macaques infected with...

Reversion of the M184V Mutation in Simian Immunodeficiency Virus Reverse Transcriptase Is Selected by Tenofovir, Even in the Presence of Lamivudine

Murry, Jeffrey P., Higgins, Joanne, Matthews, Timothy B., Huang, Victoria Y., Van Rompay, Koen K. A., Pedersen, Niels C., ...

The methionine-to-valine mutation in codon 184 (M184V) in reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) or simian immunodeficiency virus (SIV) confers resistance to...

Susceptibilities of Simian Immunodeficiency Virus to Protease Inhibitors

Giuffre, Angelica C., Higgins, Joanne, Buckheit Jr., Robert W., North, Thomas W.

We used a focal infectivity assay with HeLa H1-JC.37 cells to directly compare susceptibilities of simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) to protease...

Efavirenz Therapy in Rhesus Macaques Infected with a Chimera of Simian Immunodeficiency Virus Containing Reverse Transcriptase from Human Immunodeficiency Virus Type 1

Hofman, Michael J., Higgins, Joanne, Matthews, Timothy B., Pedersen, Niels C., Tan, Chalet, Schinazi, Raymond F., ...

The specificity of nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) for the RT of human immunodeficiency virus type 1 (HIV-1) has prevented the use of simian immunodeficiency virus (SIV)...

Suppression of Virus Load by Highly Active Antiretroviral Therapy in Rhesus Macaques Infected with a Recombinant Simian Immunodeficiency Virus Containing Reverse Transcriptase from Human Immunodeficiency Virus Type 1

North, Thomas W., Van Rompay, Koen K. A., Higgins, Joanne, Matthews, Timothy B., Wadford, Debra A., Pedersen, Niels C., ...

We have modeled highly active antiretroviral therapy (HAART) for AIDS in rhesus macaques infected with a chimera (RT-SHIV) of simian immunodeficiency virus containing reverse transcriptase from human...