Jiri Neuzil

Mitochondria transmit apoptosis signalling in cardiomyocyte-like cells and isolated hearts exposed to experimental ischemia-reperfusion injury (2007)

Neuzil, Jiri, Widen, Cecilia, Gellert, Nina, Cowie, Emma Angela, Zobalova, Renata, Dong, Lan-feng, ...

Yes

Mitochondria transmit apoptosis signalling in cardiomyocyte-like cells and isolated hearts exposed to experimental ischemia-reperfusion injury (2007)

Neuzil, Jiri, Widen, Cecilia, Gellert, Nina, Cowie, Emma Angela, Zobalova, Renata, Dong, Lan-feng, ...

A peptide conjugate of Vitamin E succinate targets breast cancer cells with high erbB2 expression (2007)

Wang, Xiufang, Birringer, Marc, Dong, Lan-feng, Veprek, Pavel, Low, Pauline, Cowie, Emma Angela, ...

Overexpression of erbB2 is associated with resistance to apoptosis. We explored whether high level of erbB2 expression by cancer cells allows their targeting using an erbB2-binding peptide (LTVSPWY)...

Vitamin E analogs, a novel group of "Mitocans," as anticancer agents: The importance of being redox-silent (2007)

Neuzil, Jiri, Tomasetti, Marco, Zhao, Yan, Dong, Lan-feng, Birringer, Marc, Wang, Xiufang, ...

The search for a selective and efficient anticancer agent for treating all neoplastic disease has yet to deliver a universally suitable compound(s). The majority of established anticancer drugs...

Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II (2007)

Neuzil, Jiri, Dyason, Jeffrey Clifford, Freeman, Ruth, Dong, Lan-feng, Prochazka, Lubomir, Wang, Xiufang, ...

Recently mitochondria in cancer cells have emerged as the Achilles heel for tumour destruction. Anti-cancer agents specifically targeting cancer cell mitochondria are referred to as 'mitocans'. These...

Apoptosis and inhibition of gap-junctional intercellular communication induced by LA-12, a novel hydrophobic platinum(IV) complex (2007)

Prochazka, Lubomir, Turanek, Jaroslav, Tesarik, Radek, Knotigova, Pavlina, Polaskova, Pavlina, Andrysik, Zdenek, ...

Yes

α-tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manner (2007)

Zhao, Yan, Zhao, Xiujuan, Yang, Baofeng, Neuzil, Jiri, Wu, Kun

Yes

α-Tocopheryl succinate inhibits angiogenesis by disrupting paracrine FGF2 signalling (2007)

Neuzil, Jiri, Cowie, Emma Angela, Wang, Xiufang, Dong, Lan-feng, Stapelberg, Michael

Malignant mesothelioma (MM) cells enhanced proliferation of endothelial cells (ECs) as well as their angiogenesis in vitro by secretion of fibroblast growth factor-2 (FGF2). This effect was...

Vitamin E Analogues and Immune Response in Cancer Treatment (2007)

Tomasetti, Marco, Neuzil, Jiri

Yes

Tumour-initiating cells vs. cancer 'stem' cells and CD133: What's in the name? (2007)

Neuzil, Jiri, Stantic, Marina, Zobalova, Renata, Chladova, Jaromira, Wang, Xiufang, Prochazka, Lubomir, ...

Recent evidence suggests that a subset of cells within a tumour have 'stem-like' characteristics. These tumour-initiating cells, distinct from non-malignant stem cells, show low proliferative rates,...

Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria (2007)

Neuzil, Jiri, Dong, Lan-feng, Ramanathapuram, Lalitha, Hahn, Tobias, Chladova, Miroslava, Wang, Xiufang, ...

Mitochondria have recently emerged as new and promising targets for cancer prevention and therapy. One of the reasons for this is that mitochondria are instrumental to many types of cell death and...

Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating endothelial cells: the role of oxidative stress (2007)

Dong, Lan-feng, Cowie, Emma Angela, Eliasson, Johanna Maria, Wang, Xiufang, Gold, Mikhal, Medunic, Yasmine, ...

''Mitocans'' from the vitamin E group of selective anticancer drugs, A-tocopheryl succinate (A-TOS) and its ether analogue A-TEA, triggered apoptosis in proliferating but not arrested endothelial...

A peptide conjugate of Vitamin E succinate targets breast cancer cells with high erbB2 expression (2007)

Wang, Xiufang, Birringer, Marc, Dong, Lan-feng, Veprek, Pavel, Low, Pauline, Cowie, Emma Angela, ...

Vitamin E analogs, a novel group of "Mitocans," as anticancer agents: The importance of being redox-silent (2007)

Neuzil, Jiri, Tomasetti, Marco, Zhao, Yan, Dong, Lan-feng, Birringer, Marc, Wang, Xiufang, ...

Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II (2007)

Neuzil, Jiri, Dyason, Jeffrey Clifford, Freeman, Ruth, Dong, Lan-feng, Prochazka, Lubomir, Wang, Xiufang, ...

Apoptosis and inhibition of gap-junctional intercellular communication induced by LA-12, a novel hydrophobic platinum(IV) complex (2007)

Prochazka, Lubomir, Turanek, Jaroslav, Tesarik, Radek, Knotigova, Pavlina, Polaskova, Pavlina, Andrysik, Zdenek, ...

α-tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manner (2007)

Zhao, Yan, Zhao, Xiujuan, Yang, Baofeng, Neuzil, Jiri, Wu, Kun

α-Tocopheryl succinate inhibits angiogenesis by disrupting paracrine FGF2 signalling (2007)

Neuzil, Jiri, Cowie, Emma Angela, Wang, Xiufang, Dong, Lan-feng, Stapelberg, Michael

Malignant mesothelioma (MM) cells enhanced proliferation of endothelial cells (ECs) as well as their angiogenesis in vitro by secretion of fibroblast growth factor-2 (FGF2). This effect was...

Vitamin E Analogues and Immune Response in Cancer Treatment (2007)

Tomasetti, Marco, Neuzil, Jiri

Tumour-initiating cells vs. cancer 'stem' cells and CD133: What's in the name? (2007)

Neuzil, Jiri, Stantic, Marina, Zobalova, Renata, Chladova, Jaromira, Wang, Xiufang, Prochazka, Lubomir, ...

Recent evidence suggests that a subset of cells within a tumour have 'stem-like' characteristics. These tumour-initiating cells, distinct from non-malignant stem cells, show low proliferative rates,...

Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria (2007)

Neuzil, Jiri, Dong, Lan-feng, Ramanathapuram, Lalitha, Hahn, Tobias, Chladova, Miroslava, Wang, Xiufang, ...

Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating endothelial celss: the role of oxidative stress (2007)

Dong, Lan-feng, Cowie, Emma Angela, Eliasson, Johanna Maria, Wang, Xiufang, Gold, Mikhal, Medunic, Yasmine, ...

Tumour-initiating cells vs. cancer 'stem' cells and CD133: What's in the name? (2007)

Neuzil, Jiri, Stantic, Marina, Zobalova, Renata, Chladova, Jaromira, Wang, Xiufang, Prochazka, Lubomir, ...

Recent evidence suggests that a subset of cells within a tumour have 'stem-like' characteristics. These tumour-initiating cells, distinct from non-malignant stem cells, show low proliferative rates,...

Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria (2007)

Neuzil, Jiri, Dong, Lan-feng, Ramanathapuram, Lalitha, Hahn, Tobias, Chladova, Miroslava, Wang, Xiufang, ...

Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating endothelial celss: the role of oxidative stress (2007)

Dong, Lan-feng, Cowie, Emma Angela, Eliasson, Johanna Maria, Wang, Xiufang, Gold, Mikhal, Medunic, Yasmine, ...

Vitamin E analogues as anti-cancer agents: Lessons from studies with a-tocopheryl succinate (2006)

Wang, Xiufang, Dong, Lan-feng, Zhao, Yan, Tomasetti, Marco, Wu, Kun, Neuzil, Jiri

Yes

Vitamin E analogues as anti-cancer agents: Lessons from studies with a-tocopheryl succinate (2006)

Wang, Xiufang, Dong, Lan-feng, Zhao, Yan, Tomasetti, Marco, Wu, Kun, Neuzil, Jiri

Yes

Vitamin E analogues as anti-cancer agents: Lessons from studies with a-tocopheryl succinate (2006)

Wang, Xiufang, Dong, Lan-feng, Zhao, Yan, Tomasetti, Marco, Wu, Kun, Neuzil, Jiri

Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway (2005)

Wang, Xiu-Fang, Whiting, Paul K., Salvatore, Brian A., Neuzil, Jiri

Yes

Hepatic processing determines dual activity of a-tocopheryl succinate: a novel paradigm for a shift in biological activity due to pro-vitamin-to-vitamin conversion (2005)

Neuzil, Jiri, Massa, Helen Maureen

Yes

a-Tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1 (2005)

Alleva, Renata, Benassi, Maria Serena, Tomasetti, Marco, Gellert, Nina, Ponticelli, Francesca, Borgha, Battista, ...

Yes

a-Lipoic acid supplementation inhibits oxidative damage accelerating chronic wound healing in patients undergoing hyperbaric oxygen therapy (2005)

Alleva, Renata, Nasole, Emmanuele, Donato, Ferruccio Di, Borghi, Battista, Neuzil, Jiri, Tomasetti, Marco

Yes

a-Tocopheryl succinate inhibits malignant mesothelioma by disrupting the Fibroblast Growth Factor Autocrine Loop: Mechanism and the role of oxidative stress (2005)

Stapelberg, Michael, Gellert, Nina, Swettenham, Emma Angela, Tomasetti, Marco, Witting, Paul K., Procopio, Antonio, ...

Yes

a-Tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: Potential therapy of malignancies of the nervous system? (2005)

Swettenham, Emma Angela, Whiting, Paul K., Salvatore, Brian A., Neuzil, Jiri

Vitamin E (VE) analogues, epitomized by ±-tocopheryl succinate (±-TOS), are potent inducers of apoptosis and anti-cancer agents. Here, we tested their effect on the highly malignant N-type...

Vitamin E amides, a new class of vitamin E analogues with enhanced pro-apoptotic activity. (2005)

Tomic-Vatic, Adisa, EyTina, John, Chapman, James, Mahdavian, Elahe, Neuzil, Jiri, Salvatore, Brian A.

Yes

Oxidative stress in myocardial ischemia reperfusion injury: a renewed focus on a long-standing area of research. (2005)

Neuzil, Jiri, Rayner, Benjamin S., Lowe, Harry C., Witting, Paul K.

Yes

Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway (2005)

Wang, Xiu-Fang, Whiting, Paul K., Salvatore, Brian A., Neuzil, Jiri

Yes

Hepatic processing determines dual activity of a-tocopheryl succinate: a novel paradigm for a shift in biological activity due to pro-vitamin-to-vitamin conversion (2005)

Neuzil, Jiri, Massa, Helen Maureen

Yes

a-Tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1 (2005)

Alleva, Renata, Benassi, Maria Serena, Tomasetti, Marco, Gellert, Nina, Ponticelli, Francesca, Borgha, Battista, ...

Yes

a-Lipoic acid supplementation inhibits oxidative damage accelerating chronic wound healing in patients undergoing hyperbaric oxygen therapy (2005)

Alleva, Renata, Nasole, Emmanuele, Donato, Ferruccio Di, Borghi, Battista, Neuzil, Jiri, Tomasetti, Marco

Yes

a-Tocopheryl succinate inhibits malignant mesothelioma by disrupting the Fibroblast Growth Factor Autocrine Loop: Mechanism and the role of oxidative stress (2005)

Stapelberg, Michael, Gellert, Nina, Swettenham, Emma Angela, Tomasetti, Marco, Witting, Paul K., Procopio, Antonio, ...

Yes

a-Tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: Potential therapy of malignancies of the nervous system? (2005)

Swettenham, Emma Angela, Whiting, Paul K., Salvatore, Brian A., Neuzil, Jiri

Vitamin E (VE) analogues, epitomized by ±-tocopheryl succinate (±-TOS), are potent inducers of apoptosis and anti-cancer agents. Here, we tested their effect on the highly malignant N-type...

Vitamin E amides, a new class of vitamin E analogues with enhanced pro-apoptotic activity. (2005)

Tomic-Vatic, Adisa, EyTina, John, Chapman, James, Mahdavian, Elahe, Neuzil, Jiri, Salvatore, Brian A.

Yes

Oxidative stress in myocardial ischemia reperfusion injury: a renewed focus on a long-standing area of research. (2005)

Neuzil, Jiri, Rayner, Benjamin S., Lowe, Harry C., Witting, Paul K.

Yes

Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway (2005)

Wang, Xiu-Fang, Whiting, Paul K., Salvatore, Brian A., Neuzil, Jiri

Hepatic processing determines dual activity of a-tocopheryl succinate: a novel paradigm for a shift in biological activity due to pro-vitamin-to-vitamin conversion (2005)

Neuzil, Jiri, Massa, Helen Maureen

a-Tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1 (2005)

Alleva, Renata, Benassi, Maria Serena, Tomasetti, Marco, Gellert, Nina, Ponticelli, Francesca, Borgha, Battista, ...

a-Lipoic acid supplementation inhibits oxidative damage accelerating chronic wound healing in patients undergoing hyperbaric oxygen therapy (2005)

Alleva, Renata, Nasole, Emmanuele, Donato, Ferruccio Di, Borghi, Battista, Neuzil, Jiri, Tomasetti, Marco

a-Tocopheryl succinate inhibits malignant mesothelioma by disrupting the Fibroblast Growth Factor Autocrine Loop: Mechanism and the role of oxidative stress (2005)

Stapelberg, Michael, Gellert, Nina, Swettenham, Emma Angela, Tomasetti, Marco, Witting, Paul K., Procopio, Antonio, ...

a-Tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: Potential therapy of malignancies of the nervous system? (2005)

Swettenham, Emma Angela, Whiting, Paul K., Salvatore, Brian A., Neuzil, Jiri

Vitamin E (VE) analogues, epitomized by ±-tocopheryl succinate (±-TOS), are potent inducers of apoptosis and anti-cancer agents. Here, we tested their effect on the highly malignant N-type...

Vitamin E amides, a new class of vitamin E analogues with enhanced pro-apoptotic activity. (2005)

Tomic-Vatic, Adisa, EyTina, John, Chapman, James, Mahdavian, Elahe, Neuzil, Jiri, Salvatore, Brian A.

Oxidative stress in myocardial ischemia reperfusion injury: a renewed focus on a long-standing area of research. (2005)

Neuzil, Jiri, Rayner, Benjamin S., Lowe, Harry C., Witting, Paul K.

alpha-Tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells (2004)

Tomasetti, M, Rippo, MR, Alleva, R, Moretti, S, Andera, L, Neuzil, Jiri, ...

Yes

Enzymatically modified low-density lipoprotein upregulates CD36 in low-differentiated monocytic cells in a peroxisome proliferator-activated receptor-gamma-dependent way (2004)

Jostarndt, K., Rubic, T., Kuhn, H., Anthonsen, M.W., Andera, L., Gellert, Nina, ...

Peroxisome proliferator-activated receptor-³ (PPAR³) has been suggested to upregulate CD36. Since free oxidized polyunsaturated fatty acids are PPAR³ ligands, we studied the effects of LDL...

A vitamin E analogue suppresses malignant mesothelioma in a preclinical model: a future drug against a fatal neoplastic disease? (2004)

Tomasetti, Marco, Gellert, Nina, Procopio, Antonio, Neuzil, Jiri

Yes

alpha-Tocopheryl succinate inhibits proliferation of mesothelioma cells by differential down-regulation of fibroblast growth factor receptors (2004)

Stapelberg, Michael, Tomasetti, Marco, Alleva, Renata, Gellert, Nina, Procopio, Antonio, Neuzil, Jiri, ...

Yes

Vitamin E analogues: a new class of inducers of apoptosis with selective anti-cancer effects (2004)

Neuzil, Jiri, Tomasetti, Marco, Mellick, Albert, Alleva, Renata, Salvatore, Brian A., Birringer, Marc, ...

Yes

Aging of cardiac myocytes in culture oxidative stress, lipofuscin accumulation, and mitochondrial turnover (2004)

Terman, Alexei, Dalen, Helge, Eaton, John W., Neuzil, Jiri, Brunk, Ulf T.

Yes

Sensitization of mesothelioma to TRAIL apoptosis by inhibition of histone deacetylase: role of Bcl-xL down-regulation (2004)

Neuzil, Jiri, Swettenham, Emma Angela, Gellert, Nina, W. Baumeister

Yes

Oxidative stress mediates toxicity of pyridoxal isonicotinoyl hydrozone analogs (2004)

Buss, Joan L., Neuzil, Jiri, Ponka, Prem

Yes

Cyclopentanone prostaglandins induce endothelial cell apoptosis independent of peroxisome proliferator activated receptor-gamma (2004)

Erl, Wolfgang, Weber, Christian, Zernecke, Alma, Neuzil, Jiri, Vosseler, Claudia A., Kim, Hyo Jung, ...

Yes

alpha-Tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells (2004)

Tomasetti, M, Rippo, MR, Alleva, R, Moretti, S, Andera, L, Neuzil, Jiri, ...

Yes

Enzymatically modified low-density lipoprotein upregulates CD36 in low-differentiated monocytic cells in a peroxisome proliferator-activated receptor-gamma-dependent way (2004)

Jostarndt, K., Rubic, T., Kuhn, H., Anthonsen, M.W., Andera, L., Gellert, Nina, ...

Peroxisome proliferator-activated receptor-³ (PPAR³) has been suggested to upregulate CD36. Since free oxidized polyunsaturated fatty acids are PPAR³ ligands, we studied the effects of LDL...

A vitamin E analogue suppresses malignant mesothelioma in a preclinical model: a future drug against a fatal neoplastic disease? (2004)

Tomasetti, Marco, Gellert, Nina, Procopio, Antonio, Neuzil, Jiri

Yes

alpha-Tocopheryl succinate inhibits proliferation of mesothelioma cells by differential down-regulation of fibroblast growth factor receptors (2004)

Stapelberg, Michael, Tomasetti, Marco, Alleva, Renata, Gellert, Nina, Procopio, Antonio, Neuzil, Jiri

Yes

Vitamin E analogues: a new class of inducers of apoptosis with selective anti-cancer effects (2004)

Neuzil, Jiri, Tomasetti, Marco, Mellick, Albert, Alleva, Renata, Salvatore, Brian A., Birringer, Marc, ...

Yes

Aging of cardiac myocytes in culture oxidative stress, lipofuscin accumulation, and mitochondrial turnover (2004)