Estradiol attenuates the K + -induced increase in extracellular GABA in rat striatum (2006)
Hu, Ming, Watson, Christopher J., Kennedy, Robert T., Becker, Jill B.
Estradiol acts rapidly and directly to inhibit L-type Ca 2+ current in medium spiny neurons from striatum. Since medium spiny neurons contain Γ-aminobutyric acid (GABA), we hypothesized that...
Strategies and Methods for Research on Sex Differences in Brain and Behavior (2005)
Becker, Jill B., Arnold, Arthur P., Berkley, Karen J., Blaustein, Jeffrey D., Eckel, Lisa, Hampson, Elizabeth, ...
Female and male brains differ. Differences begin early during development due to a combination of genetic and hormonal events and continue throughout the lifespan of an individual. Although...
Effects of estrogen agonists on amphetamine-stimulated striatal dopamine release (1998)
Based upon the observation that estrogen acts in the striatum to rapidly modulate dopamine (DA) neural transmission and DA-mediated behaviors, it has been postulated that these effects of estrogen...
Sex differences in basal extracellular striatal dopamine concentrations in gonadectomized male and female rats have been reported previously. In the current experiment, estrous cycle-dependent...
Bazzett, Terence J., Becker, Jill B., Falik, R. C., Albin, Roger L.
Peer Reviewed
Bazzett, Terence J., Becker, Jill B.
Regional changes in striatal D2 dopamine (DA) receptor binding in castrated (CAST) or ovariectomized (OVX) rats were investigated following administration of a low dose of estradiol benzoate (EB),...
Sex differences in striatal dopamine: in vivo microdialysis and behavioral studies (1993)
Castner, Stacy A., Xiao, Li, Becker, Jill B.
Experiments were conducted to examine sex differences in striatal dopamine function using in vivo microdialysis in freely moving rats. We report here a sex difference in basal extracellular striatal...
Bazzett, Terence J., Becker, Jill B., Kaatz, Kevin W., Albin, Roger L.
The excitotoxic hypothesis of Huntington's disease pathogenesis suggests that selective striatal neuronal loss results from excessive activation of striatal excitatory amino acid receptors. Using a...
Effects of adrenal medulla grafts on plasma catecholamines and rotational behavior (1992)
Takashima, Hidetoshi, Poltorak, Maciej, Becker, Jill B., Freed, William J.
The mechanisms by which adrenal medulla grafts influence the function of host brains in animal models of Parkinson's disease are unclear. To explore this issue, fragments of adrenal medulla or...
A novel device for chronic intracranial drug delivery via microdialysis (1991)
Bazzett, Terence J., Becker, Jill B., Albin, Roger L.
A system is described for chronic intracranial drug administration in the rat using a modified in vivo microdialysis probe coupled to an Alzet model 2002 osmotic minipump. The results presented...
Curran, Eileen J., Becker, Jill B.
Intraventricular adrenal medulla grafts were found to produce dissociable effects on rotational behavior induced by amphetamine and apomorphine in rats with unilateral striatal dopamine depletions....
Intracerebral adrenal medulla grafts: A review (1990)
Freed, William J., Poltorak, Maciej, Becker, Jill B.
This review summarizes basic and clinical research on intracerebral adrenal medulla grafts, emphasizing potential applications to Parkinson's disease. Properties of intraventricular and...
Ovariectomy (OVX) of female rats results in a decreased behavioral response to stimulation of the mesostriatal dopamine (DA) system and decreased striatal DA release in vitro. Estrogen replacement...
Becker, Jill B., Robinson, Terry E., Barton, Peter, Sintov, Amnon, Siden, Rivka, Levy, Robert J.
This study was conducted to determine if the behavioral asymmetry associated with unilateral nigrostriatal dopamine (DA) depletion could be alleviated by placing a small DA-releasing silicone polymer...
Direct effect of 17Β-estradiol on striatum: Sex differences in dopamine release (1990)
The nigrostriatal dopamine (DA) system is sexually dimorphic. In female but not male rats, striatal DA activity is modulated by gonadal steroid hormones. Ovariectomy (OVX) decreases striatal DA...
Becker, Jill B., Freed, William J.
Adrenal medulla grafts in the lateral ventricle reduce the behavioral manifestations of striatal dopamine depletion in an animal model of Parkinson's disease. Using microdialysis in freely moving...
Becker, Jill B., Adams, Frank, Robinson, Terry E.
A new method is described to estimate the cerebrospinal fluid (CSF) concentrations of monoamine metabolites (dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid...
Castaneda, Edward, Becker, Jill B., Robinson, Terry E.
Exposure to amphetamine (AMPH) in vivo produces an enduring enhancement (`sensitization') in AMPH-stimulated striatal DA release in vitro. Experiments were conducted to determine whether striatal DA...
Robinson, Terry E., Becker, Jill B., Young, Elizabeth A., Akil, Huda, Castaneda, Edward
The repeated intermittent administration of amphetamine (AMP) produces an enduring enhancement in the response of dopamine (DA) systems in the brain to a subsequent "challenge" with amphetamine....
Becker, Jill B., Snyder, Peter J., Miller, Melissa M., Westgate, Sara A., Jenuwine, Michael J.
The influence of estrous cycle and intrastriatal implants of 17beta-estradiol (17[beta]-estradiol). 17alpha-estradiol (17[alpha]-estradiol) or cholesterol on the number of footfaults made by female...
Whishaw, Ian Q., Sutherland, Robert J., Kolb, Bryan, Becker, Jill B.
The experiments examined the contributions of forebrain noradrenaline and environmental enrichment to recovery of place navigation ability in rats after hemidecortication in infancy or adulthood....
Camp, Dianne M., Becker, Jill B., Robinson, Terry E.
The effects of gonadectomy on amphetamine-induced rotational behavior were studied in male and female rats. Different systemic doses were used to produce equivalent brain concentrations of the drug...
Robinson, Terry E., Becker, Jill B.
Some people who repeatedly use stimulant drugs, such as amphetamine (AMPH), develop an AMPH-induced psychosis that is similar to paranoid schizophrenia. There has been, therefore, considerable...
Robinson, Terry E., Becker, Jill B.
8. SummarySome people who repeatedly use stimulant drugs, such as amphetamine (AMPH), develop an AMPH-induced psychosis that is similar to paranoid schizophrenia. There has been, therefore,...
Wilcox, Richard A., Robinson, Terry E., Becker, Jill B.
Peer Reviewed
Becker, Jill B., Beer, Mary E.
The results of 3 experiments examining the influence of estrogen on the nigrostriatal dopamine (DA) system are reported. In two experiments the influence of hormonal manipulations on amphetamine...
Robinson, Terry E., Becker, Jill B., Moore, C. J., Castaneda, Edward, Mittleman, Guy
It is reported that in rats the repeated intermittent administration of amphetamine produces a long-lasting enhancement in medial frontal cortex dopamine utilization. This change in mesocortical...
Robinson, Terry E., Angus, Amy L., Becker, Jill B.
In rats with a unilateral 6-OHDA lesion of the substantia nigra exposure to footshock or immobilization stress produced a long-lasting enhancement in the rotational behavior evoked by a subsequent...
Sensitization of rotational behavior produced by a single exposure to cocaine (1985)
Lin-Chu, Guan, Robinson, Terry E., Becker, Jill B.
In rats with a unilateral 6-OHDA lesion of the substantia nigra a single exposure to cocaine significantly enhanced the ipsiversive rotational behavior produced by a second injection given one week...
Castaneda, Edward, Robinson, Terry E., Becker, Jill B.
This experiment was conducted to determine if nigrostriatal dopamine (DA) neurons are necessary for the contraversive rotational behavior evoked by electrical stimulation in the lateral hypothalamus....
Becker, Jill B., Beer, Mary E., Robinson, Terry E.
The release of endogenous dopamine (DA) from rat striatal tissue was studied in an in vitro superfusion system following hormonal manipulations in vivo. Progesterone treatment in estrogen-primed...
Camp, Dianne M., Robinson, Terry E., Becker, Jill B.
The influence of early experience (preweaning handling) on the development of several postural/motor asymmetries (side bias in an open field, turn preference in a T-maze, amphetamine-induced...
Becker, Jill B., Castaneda, Edward, Robinson, Terry E., Beer, Mary E.
An easily constructed, inexpensive and simple system is described for the superfusion of neural tissue. To characterize the system, the dynamics of endogenous dopamine and dihydroxyphenylacetic acid...
Robinson, Terry E., Becker, Jill B.
A basic assumption of the `rotational behavior model' is that amphetamine (AMPH) produces ipsiversive rotational behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal...
Robinson, Terry E., Becker, Jill B., Presty, Sharon K.
Amphetamine (AMPH)-induced rotational behavior in non-lesioned rats and AMPH-stimulated dopamine (DA) release from striatal tissue fragments in vitro were used to study the long-term effects of a...
Robinson, Terry E., Becker, Jill B.
Peer Reviewed
Robinson, Terry E., Camp, Dianne M., Jacknow, Dale S., Becker, Jill B.
In this study electrical stimulation-induced rotational behavior was used as a behavioral index of mesostriatal dopamine (DA) activity to investigate gender and hormonal influences on the DA system....
Sutherland, Robert J., Kolb, Bryan, Whishaw, Ian Q., Becker, Jill B.
The possibility that cortical noradrenaline (NA) is necessary for the sparing of function that occurs after neonatal frontal cortex damage was examined. Spatial localization by rats with frontal...
Sex difference and estrous cycle variations in amphetamine-elicited rotational behavior (1982)
Becker, Jill B., Robinson, Terry E., Lorenz, Kimberly A.
The experiments reported here were designed to determine if there are sex- and/or estrous cycle-dependent differences in amphetamine (AMPH)-elicited rotational behavior in unlesioned rats. Whole...
Robinson, Terry E., Camp, Dianne M., Becker, Jill B.
Rotational behavior induced by electrical stimulation of ascending dopamine neurons is used as a behavioral model to investigate gender and hormonal influences on extra-hypothalamic dopamine systems....
Robinson, Terry E., Becker, Jill B., Ramirez, V. D.
Sex differences are described in both a lateralized behavior (amphetamine-elicited rotation) and in the lateralization of striatal dopamine (DA) content. Amphetamine (AMPH) elicited significantly...
Bergdall, Valerie K., Becker, Jill B.
NGF was infused into the lateral ventricle of rats with unilateral 6-OHDA lesions of the substantia nigra along with adrenal medulla or control grafts. Treatment effectiveness, as measured by...