Jiaming Zhu

RNase P-mediated inhibition of cytomegalovirus protease expression and viral DNA encapsidation by oligonucleotide external guide sequences

Dunn, Walter, Trang, Phong, Khan, Umair, Zhu, Jiaming, Liu, Fenyong

External guide sequences (EGSs) are oligonucleotides that consist of a sequence complementary to a target mRNA and recruit intracellular RNase P for specific degradation of the target RNA. In this...

In Vitro and In Vivo Characterization of a Murine Cytomegalovirus with a Mutation at Open Reading Frame m166

Zhu, Jiaming, Chen, Jennifer, Hai, Rong, Tong, Tuong, Xiao, Jianqiao, Zhan, Xiaoyan, ...

We have recently generated a pool of murine cytomegalovirus (MCMV) mutants by using a Tn3-based transposon mutagenesis approach. In this study, one of the mutants, Rvm166, which contained the...

Murine Cytomegalovirus with a Transposon Insertional Mutation at Open Reading Frame M35 Is Defective in Growth In Vivo

Tam, Ada, Zhu, Jiaming, Hai, Rong, Haghjoo, Erik, Tong, Tuong, Zhan, Xiaoyan, ...

We had previously constructed a pool of murine cytomegalovirus (MCMV) mutants that contained a Tn3-based transposon sequence randomly inserted in the viral genome. In the study reported here, one of...

Murine Cytomegalovirus with a Transposon Insertional Mutation at Open Reading Frame m155 Is Deficient in Growth and Virulence in Mice

Abenes, Gerardo, Chan, Karen, Lee, Manfred, Haghjoo, Erik, Zhu, Jiaming, Zhou, Tianhong, ...

A pool of murine cytomegalovirus (MCMV) mutants was previously generated by using a Tn3-based transposon mutagenesis approach (X. Zhan, M. Lee, J. Xiao, and F. Liu, J. Virol. 74:7411-7421, 2000). In...

Effective inhibition of Rta expression and lytic replication of Kaposi's sarcoma-associated herpesvirus by human RNase P

Zhu, Jiaming, Trang, Phong, Kim, Kihoon, Zhou, Tianhong, Deng, Hongyu, Liu, Fenyong

Ribonuclease P (RNase P) complexed with external guide sequence (EGS) represents a nucleic acid-based gene interference approach to knock-down gene expression. Unlike other strategies, such as...

RNase P-mediated inhibition of cytomegalovirus protease expression and viral DNA encapsidation by oligonucleotide external guide sequences

Dunn, Walter, Trang, Phong, Khan, Umair, Zhu, Jiaming, Liu, Fenyong

External guide sequences (EGSs) are oligonucleotides that consist of a sequence complementary to a target mRNA and recruit intracellular RNase P for specific degradation of the target RNA. In this...

In Vitro and In Vivo Characterization of a Murine Cytomegalovirus with a Mutation at Open Reading Frame m166

Zhu, Jiaming, Chen, Jennifer, Hai, Rong, Tong, Tuong, Xiao, Jianqiao, Zhan, Xiaoyan, ...

We have recently generated a pool of murine cytomegalovirus (MCMV) mutants by using a Tn3-based transposon mutagenesis approach. In this study, one of the mutants, Rvm166, which contained the...

Murine Cytomegalovirus with a Transposon Insertional Mutation at Open Reading Frame M35 Is Defective in Growth In Vivo

Tam, Ada, Zhu, Jiaming, Hai, Rong, Haghjoo, Erik, Tong, Tuong, Zhan, Xiaoyan, ...

We had previously constructed a pool of murine cytomegalovirus (MCMV) mutants that contained a Tn3-based transposon sequence randomly inserted in the viral genome. In the study reported here, one of...

Murine Cytomegalovirus with a Transposon Insertional Mutation at Open Reading Frame m155 Is Deficient in Growth and Virulence in Mice

Abenes, Gerardo, Chan, Karen, Lee, Manfred, Haghjoo, Erik, Zhu, Jiaming, Zhou, Tianhong, ...

A pool of murine cytomegalovirus (MCMV) mutants was previously generated by using a Tn3-based transposon mutagenesis approach (X. Zhan, M. Lee, J. Xiao, and F. Liu, J. Virol. 74:7411-7421, 2000). In...

Effective inhibition of Rta expression and lytic replication of Kaposi's sarcoma-associated herpesvirus by human RNase P

Zhu, Jiaming, Trang, Phong, Kim, Kihoon, Zhou, Tianhong, Deng, Hongyu, Liu, Fenyong

Ribonuclease P (RNase P) complexed with external guide sequence (EGS) represents a nucleic acid-based gene interference approach to knock-down gene expression. Unlike other strategies, such as...