Jesper Nylandsted

Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression. (2003)

Hansson, Oskar, Nylandsted, Jesper, Castilho, Roger F, Leist, Marcel, Jäättelä, Marja, Brundin, Patrik

Abstract is not available

Lack of neuroprotection by heat shock protein 70 overexpression in a mouse model of global cerebral ischemia. (2003)

Olsson, Tomas, Hansson, Oskar, Nylandsted, Jesper, Jäättelä, Marja, Smith, Maj-Lis, Wieloch, Tadeusz

Abstract is not available

Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2

Nylandsted, Jesper, Rohde, Mikkel, Brand, Karsten, Bastholm, Lone, Elling, Folmer, Jäättelä, Marja

Heat shock protein 70 is an antiapoptotic chaperone protein highly expressed in human breast tumors and tumor cell lines. Here, we demonstrate that the mere inhibition of its synthesis by adenoviral...

Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms

Rohde, Mikkel, Daugaard, Mads, Jensen, Mette Hartvig, Helin, Kristian, Nylandsted, Jesper, Jäättelä, Marja

Whereas the stress-inducible heat-shock protein 70 (Hsp70) has gained plenty of attention as a putative target for tumor therapy, little is known about the role of other Hsp70 proteins in cancer....

Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2

Nylandsted, Jesper, Rohde, Mikkel, Brand, Karsten, Bastholm, Lone, Elling, Folmer, Jäättelä, Marja

Heat shock protein 70 is an antiapoptotic chaperone protein highly expressed in human breast tumors and tumor cell lines. Here, we demonstrate that the mere inhibition of its synthesis by adenoviral...

Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms

Rohde, Mikkel, Daugaard, Mads, Jensen, Mette Hartvig, Helin, Kristian, Nylandsted, Jesper, Jäättelä, Marja

Whereas the stress-inducible heat-shock protein 70 (Hsp70) has gained plenty of attention as a putative target for tumor therapy, little is known about the role of other Hsp70 proteins in cancer....

Apoptosome-Independent Activation of the Lysosomal Cell Death Pathway by Caspase-9▿ †

Gyrd-Hansen, Mads, Farkas, Thomas, Fehrenbacher, Nicole, Bastholm, Lone, Høyer-Hansen, Maria, Elling, Folmer, ...

The apoptosome, a heptameric complex of Apaf-1, cytochrome c, and caspase-9, has been considered indispensable for the activation of caspase-9 during apoptosis. By using a large panel of genetically...

Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization

Nylandsted, Jesper, Gyrd-Hansen, Mads, Danielewicz, Agnieszka, Fehrenbacher, Nicole, Lademann, Ulrik, Høyer-Hansen, Maria, ...

Heat shock protein 70 (Hsp70) is a potent survival protein whose depletion triggers massive caspase-independent tumor cell death. Here, we show that Hsp70 exerts its prosurvival function by...