Jesús Egido

Proteomic Analysis of Circulating Monocytes Identifies Cathepsin D as A Potential Novel Plasma Marker of Acute Coronary Syndromes (2008)

Maria G. Barderas, Verónica M. Dardé, Julio Jiménez-Narcher, ...

We have performed a proteomic analysis of peripheral blood monocytes from ACS patients in comparison with healthy subjects and stable coronary patients in order to search novel biomarkers of ACS in...

Butter and walnuts, but not olive oil, elicit postprandial activation of nuclear transcription factor κB in peripheral blood mononuclear cells from healthy men (2004)

Bellido, Cecilia, López Miranda, José, Blanco Colio, Luis Miguel, Pérez Martínez, Pablo, Muriana, Francisco José, Martín Ventura, José Luis, ...

Background:Nuclear transcription factor {kappa}B (NF-{kappa}B) plays an important role in atherosclerosis by modulating gene expression. Postprandial lipemia has been correlated with an increase in...

Disfunción endotelial, inflamación y estatinas: nuevas evidencias (2004)

Tuñón, José, Egido, Jesús

Persistent Proteinuria Up-Regulates Angiotensin II Type 2 Receptor and Induces Apoptosis in Proximal Tubular Cells

Tejera, Nuria, Gómez-Garre, Dulcenombre, Lázaro, Alberto, Gallego-Delgado, Julio, Alonso, Covadonga, Blanco, Julia, ...

Apoptosis is implicated in the progressive cell loss and fibrosis both at glomerular and tubulointerstitial level. In this study, we examined the potential mechanisms by which persistent proteinuria...

ACE Inhibitor Quinapril Reduces the Arterial Expression of NF-κB-Dependent Proinflammatory Factors but not of Collagen I in a Rabbit Model of Atherosclerosis

Hernández-Presa, Miguel A., Bustos, Carmen, Ortego, Mónica, Tuñón, José, Ortega, Luis, Egido, Jesús

Increasing evidence supports an association between inflammation and plaque rupture. Macrophages and vascular smooth muscle cells are a source of cytokines and growth factors, which contribute to...

Renal Tubulointerstitial Damage Caused by Persistent Proteinuria Is Attenuated in AT1-Deficient Mice : Role of Endothelin-1

Suzuki, Yusuke, Lopez-Franco, Oscar, Gomez-Garre, Dulcenombre, Tejera, Nuria, Gomez-Guerrero, Carmen, Sugaya, Takeshi, ...

Using angiotensin II (AngII) type 1A receptor-deficient mice [AT1(−/−)], in which we induced protein overload nephropathy, we explored the potential implication of AngII and endothelin-1 (ET-1)...

Nuclear Factor-κB Inhibitors as Potential Novel Anti-Inflammatory Agents for the Treatment of Immune Glomerulonephritis

López-Franco, Oscar, Suzuki, Yusuke, Sanjuán, Guillermo, Blanco, Julia, Hernández-Vargas, Purificación, Yo, Yoshikage, ...

Nuclear factor (NF)-κB regulates several genes implicated in the inflammatory response and represents an interesting therapeutic target. We examined the effects of gliotoxin (a fungal metabolite)...

Angiotensin II Increases Connective Tissue Growth Factor in the Kidney

Rupérez, Monica, Ruiz-Ortega, Marta, Esteban, Vanesa, Lorenzo, Óscar, Mezzano, Sergio, Plaza, Juan Jose, ...

Connective tissue growth factor (CTGF) has been described as a novel fibrotic mediator. CTGF is overexpressed in several kidney diseases and is induced by different factors involved in renal injury....

Common pathways of hypercholesterolemia and hypertension leading to atherothrombosis: the need for a global approach in the management of cardiovascular risk factors

Tuñón, José, Blanco-Colio, Luis Miguel, Tarín, Nieves, Egido, Jesús

In the last years there has been increasing evidence suggesting that the treatment of cardiovascular risk factors must be done on a global rather than on a separate approach, because they have...