PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry (2006)
Groszer, Matthias, Erickson, Rebecca, Scripture-Adams, Dierdre D., Dougherty, Jospeh D., Le Belle, Janel, Zack, Jerome A., ...
Previous studies have demonstrated that a small subpopulation of brain tumor cells share key characteristics with neural stem/progenitor cells in terms of phenotype and behavior. These findings...
Ali, Ayub, Lubong, Rachel, Ng, Hwee, Brooks, David G, Zack, Jerome A, Yang, Otto O
The determinants of CD8(+) cytotoxic T-lymphocyte (CTL) antiviral activity against human immunodeficiency virus type 1 (HIV-1) remain poorly defined. Although recent technological advances have...
Vita.
Impaired response to HAART in HIV-infected individuals with high autonomic nervous system activity
Cole, Steve W., Naliboff, Bruce D., Kemeny, Margaret E., Griswold, Marshall P., Fahey, John L., Zack, Jerome A.
Neurotransmitters can accelerate HIV-1 replication in vitro, leading us to examine whether differences in autonomic nervous system (ANS) activity might promote residual HIV-1 replication in patients...
Korin, Yael D., Zack, Jerome A.
Successful infection by human immunodeficiency virus type 1 (HIV-1) requires the activation of target cells. Infection of quiescent peripheral CD4 lymphocytes by HIV-1 results in incomplete, labile,...
In Vivo Pathogenesis of a Human Immunodeficiency Virus Type 1 Reporter Virus
Jamieson, Beth D., Zack, Jerome A.
Our understanding of human immunodeficiency virus type 1 (HIV-1)-induced pathogenesis is hampered by the inability to detect HIV-1 gene expression in infected viable cells. In this report, we...
Regions of Human Immunodeficiency Virus Type 1 nef Required for Function In Vivo
Aldrovandi, Grace M., Gao, Lianying, Bristol, Gregory, Zack, Jerome A.
In vivo studies in monkeys and humans have indicated that immunodeficiency viruses with Nef deleted are nonpathogenic in immunocompetent hosts, and this has motivated a search for live attenuated...
Human Immunodeficiency Virus Inhibits Multilineage Hematopoiesis In Vivo
Koka, Prasad S., Fraser, John K., Bryson, Yvonne, Bristol, Gregory C., Aldrovandi, Grace M., Daar, Eric S., ...
Human immunodeficiency virus type 1 (HIV-1)-infected individuals often exhibit multiple hematopoietic abnormalities reaching far beyond loss of CD4+ lymphocytes. We used the SCID-hu (Thy/Liv) mouse...
Kitchen, Scott G., Korin, Yael D., Roth, Michael D., Landay, Alan, Zack, Jerome A.
Human immunodeficiency virus type 1 (HIV-1) infection requires cell surface expression of CD4. Costimulation of CD8+/CD4− T lymphocytes by anti-CD3 and anti-CD28 antibodies or by allogeneic...
Functional Reconstitution of Thymopoiesis after Human Immunodeficiency Virus Infection
Kitchen, Scott G., Killian, Scott, Giorgi, Janis V., Zack, Jerome A.
We have utilized combination antiretroviral therapy following human immunodeficiency virus type 1-induced human CD4+ thymocyte depletion in the SCID-hu mouse to examine the immune competence of...
Camerini, David, Su, Hua-Poo, Gamez-Torre, Graciela, Johnson, Michael L., Zack, Jerome A., Chen, Irvin S. Y.
Human immunodeficiency virus type 1 (HIV-1) patient isolates and molecular clones were used to analyze the determinants responsible for human CD4+ thymocyte depletion in SCID-hu mice....
Amado, Rafael G., Jamieson, Beth D., Cortado, Ruth, Cole, Steve W., Zack, Jerome A.
Human immunodeficiency virus type 1 (HIV-1)-infected SCID-hu thymic implants depleted of CD4+ cells can support renewed thymopoiesis derived from both endogenous and exogenous T-cell progenitors...
Nonproductive Human Immunodeficiency Virus Type 1 Infection in Nucleoside-Treated G0 Lymphocytes
Korin, Yael D., Zack, Jerome A.
Productive infection by human immunodeficiency virus type 1 (HIV-1) requires the activation of target cells. Infection of quiescent peripheral CD4 lymphocytes by HIV-1 results in incomplete, labile,...
Koka, Prasad S., Jamieson, Beth D., Brooks, David G., Zack, Jerome A.
Human immunodeficiency virus (HIV)-infected individuals exhibit a variety of hematopoietic dysfunctions. The SCID-hu mouse (severe combined immunodeficient mouse transplanted with human fetal thymus...
Gorry, Paul R., Bristol, Greg, Zack, Jerome A., Ritola, Kimberly, Swanstrom, Ronald, Birch, Chris J., ...
The viral determinants that underlie human immunodeficiency virus type 1 (HIV-1) neurotropism are unknown, due in part to limited studies on viruses isolated from brain. Previous studies suggest that...
Cole, Alexander M., Hong, Teresa, Boo, Lee Ming, Nguyen, Tung, Zhao, Chengquan, Bristol, Greg, ...
Human bone marrow expresses a pseudogene that encodes an antimicrobial peptide homologous to rhesus monkey circular minidefensins (θ-defensins). We prepared the putative ancestral human peptide by...
Effect of Latent Human Immunodeficiency Virus Infection on Cell Surface Phenotype
Brooks, David G., Zack, Jerome A.
Highly active antiretroviral therapy has succeeded in many cases in suppressing virus production in patients infected with human immunodeficiency virus (HIV); however, once treatment is discontinued,...
Scripture-Adams, Deirdre D., Brooks, David G., Korin, Yael D., Zack, Jerome A.
Latent human immunodeficiency virus type 1 (HIV-1) persists even in patients treated with antiretroviral therapy. New treatment strategies are therefore needed to eradicate this latent viral...
Human Immunodeficiency Virus Type 1 Infection and Replication in Normal Human Oral Keratinocytes
Liu, Xuan, Zha, Junli, Chen, Hongying, Nishitani, Junko, Camargo, Paulo, Cole, Steve W., ...
Recent epidemiologic studies show increasing human immunodeficiency virus type 1 (HIV-1) transmission through oral-genital contact. This paper examines the possibility that normal human oral...
Identification of T cell-signaling pathways that stimulate latent HIV in primary cells
Brooks, David G., Arlen, Philip A., Gao, Lianying, Kitchen, Christina M. R., Zack, Jerome A.
Eradication of HIV infection depends on the elimination of a small, but stable population of latently infected T cells. After the discontinuation of therapy, activation of latent virus can rekindle...
Ali, Ayub, Lubong, Rachel, Ng, Hwee, Brooks, David G., Zack, Jerome A., Yang, Otto O.
The determinants of CD8+ cytotoxic T-lymphocyte (CTL) antiviral activity against human immunodeficiency virus type 1 (HIV-1) remain poorly defined. Although recent technological advances have...
CD4 on CD8+ T cells directly enhances effector function and is a target for HIV infection
Kitchen, Scott G., Jones, Nicole R., LaForge, Stuart, Whitmire, Jason K., Vu, Bien-Aimee, Galic, Zoran, ...
Costimulation of purified CD8+ T lymphocytes induces de novo expression of CD4, suggesting a previously unrecognized function for this molecule in the immune response. Here, we report that the CD4...
Kitchen, Scott G., Whitmire, Jason K., Jones, Nicole R., Galic, Zoran, Kitchen, Christina M. R., Ahmed, Rafi, ...
CD8+ T lymphocytes play a major role in cellular-mediated immune responses to foreign antigen. We have previously demonstrated that costimulation of purified human CD8+ T cells induces de novo...
Chang, Margaret, Brown, Helen J., Collado-Hidalgo, Alicia, Arevalo, Jesusa M., Galic, Zoran, Symensma, Tonia L., ...
Reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication is mediated by the viral RTA transcription factor, but little is known about the physiological processes controlling...
Effects of Prostratin on T-Cell Activation and Human Immunodeficiency Virus Latency
Korin, Yael D., Brooks, David G., Brown, Stephen, Korotzer, Andrew, Zack, Jerome A.
Human immunodeficiency virus (HIV) replication is linked to cellular gene transcription and requires target cell activation. The latent reservoir of HIV-1 in quiescent T cells is thought to be a...
Rapid Expression of Human Immunodeficiency Virus following Activation of Latently Infected Cells
Arlen, Philip A., Brooks, David G., Gao, Lian Y., Vatakis, Dimitrios, Brown, Helen J., Zack, Jerome A.
The host cell activation state impacts the nature of human immunodeficiency virus infection. Activated cells facilitate productive infections; quiescent cells enable the virus to enter a latent...
PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry
Groszer, Matthias, Erickson, Rebecca, Scripture-Adams, Deirdre D., Dougherty, Joseph D., Le Belle, Janel, Zack, Jerome A., ...
Previous studies have demonstrated that a small subpopulation of brain tumor cells share key characteristics with neural stem/progenitor cells in terms of phenotype and behavior. These findings...
Impaired response to HAART in HIV-infected individuals with high autonomic nervous system activity
Cole, Steve W., Naliboff, Bruce D., Kemeny, Margaret E., Griswold, Marshall P., Fahey, John L., Zack, Jerome A.
Neurotransmitters can accelerate HIV-1 replication in vitro, leading us to examine whether differences in autonomic nervous system (ANS) activity might promote residual HIV-1 replication in patients...
Korin, Yael D., Zack, Jerome A.
Successful infection by human immunodeficiency virus type 1 (HIV-1) requires the activation of target cells. Infection of quiescent peripheral CD4 lymphocytes by HIV-1 results in incomplete, labile,...
In Vivo Pathogenesis of a Human Immunodeficiency Virus Type 1 Reporter Virus
Jamieson, Beth D., Zack, Jerome A.
Our understanding of human immunodeficiency virus type 1 (HIV-1)-induced pathogenesis is hampered by the inability to detect HIV-1 gene expression in infected viable cells. In this report, we...
Regions of Human Immunodeficiency Virus Type 1 nef Required for Function In Vivo
Aldrovandi, Grace M., Gao, Lianying, Bristol, Gregory, Zack, Jerome A.
In vivo studies in monkeys and humans have indicated that immunodeficiency viruses with Nef deleted are nonpathogenic in immunocompetent hosts, and this has motivated a search for live attenuated...
Human Immunodeficiency Virus Inhibits Multilineage Hematopoiesis In Vivo
Koka, Prasad S., Fraser, John K., Bryson, Yvonne, Bristol, Gregory C., Aldrovandi, Grace M., Daar, Eric S., ...
Human immunodeficiency virus type 1 (HIV-1)-infected individuals often exhibit multiple hematopoietic abnormalities reaching far beyond loss of CD4+ lymphocytes. We used the SCID-hu (Thy/Liv) mouse...
Kitchen, Scott G., Korin, Yael D., Roth, Michael D., Landay, Alan, Zack, Jerome A.
Human immunodeficiency virus type 1 (HIV-1) infection requires cell surface expression of CD4. Costimulation of CD8+/CD4− T lymphocytes by anti-CD3 and anti-CD28 antibodies or by allogeneic...
Functional Reconstitution of Thymopoiesis after Human Immunodeficiency Virus Infection
Kitchen, Scott G., Killian, Scott, Giorgi, Janis V., Zack, Jerome A.
We have utilized combination antiretroviral therapy following human immunodeficiency virus type 1-induced human CD4+ thymocyte depletion in the SCID-hu mouse to examine the immune competence of...
Camerini, David, Su, Hua-Poo, Gamez-Torre, Graciela, Johnson, Michael L., Zack, Jerome A., Chen, Irvin S. Y.
Human immunodeficiency virus type 1 (HIV-1) patient isolates and molecular clones were used to analyze the determinants responsible for human CD4+ thymocyte depletion in SCID-hu mice....
Amado, Rafael G., Jamieson, Beth D., Cortado, Ruth, Cole, Steve W., Zack, Jerome A.
Human immunodeficiency virus type 1 (HIV-1)-infected SCID-hu thymic implants depleted of CD4+ cells can support renewed thymopoiesis derived from both endogenous and exogenous T-cell progenitors...
Nonproductive Human Immunodeficiency Virus Type 1 Infection in Nucleoside-Treated G0 Lymphocytes
Korin, Yael D., Zack, Jerome A.
Productive infection by human immunodeficiency virus type 1 (HIV-1) requires the activation of target cells. Infection of quiescent peripheral CD4 lymphocytes by HIV-1 results in incomplete, labile,...
Koka, Prasad S., Jamieson, Beth D., Brooks, David G., Zack, Jerome A.
Human immunodeficiency virus (HIV)-infected individuals exhibit a variety of hematopoietic dysfunctions. The SCID-hu mouse (severe combined immunodeficient mouse transplanted with human fetal thymus...
Gorry, Paul R., Bristol, Greg, Zack, Jerome A., Ritola, Kimberly, Swanstrom, Ronald, Birch, Chris J., ...
The viral determinants that underlie human immunodeficiency virus type 1 (HIV-1) neurotropism are unknown, due in part to limited studies on viruses isolated from brain. Previous studies suggest that...
Cole, Alexander M., Hong, Teresa, Boo, Lee Ming, Nguyen, Tung, Zhao, Chengquan, Bristol, Greg, ...
Human bone marrow expresses a pseudogene that encodes an antimicrobial peptide homologous to rhesus monkey circular minidefensins (θ-defensins). We prepared the putative ancestral human peptide by...
Effect of Latent Human Immunodeficiency Virus Infection on Cell Surface Phenotype
Brooks, David G., Zack, Jerome A.
Highly active antiretroviral therapy has succeeded in many cases in suppressing virus production in patients infected with human immunodeficiency virus (HIV); however, once treatment is discontinued,...
Scripture-Adams, Deirdre D., Brooks, David G., Korin, Yael D., Zack, Jerome A.
Latent human immunodeficiency virus type 1 (HIV-1) persists even in patients treated with antiretroviral therapy. New treatment strategies are therefore needed to eradicate this latent viral...
Human Immunodeficiency Virus Type 1 Infection and Replication in Normal Human Oral Keratinocytes
Liu, Xuan, Zha, Junli, Chen, Hongying, Nishitani, Junko, Camargo, Paulo, Cole, Steve W., ...
Recent epidemiologic studies show increasing human immunodeficiency virus type 1 (HIV-1) transmission through oral-genital contact. This paper examines the possibility that normal human oral...
Effects of Prostratin on T-Cell Activation and Human Immunodeficiency Virus Latency
Korin, Yael D., Brooks, David G., Brown, Stephen, Korotzer, Andrew, Zack, Jerome A.
Human immunodeficiency virus (HIV) replication is linked to cellular gene transcription and requires target cell activation. The latent reservoir of HIV-1 in quiescent T cells is thought to be a...
Identification of T cell-signaling pathways that stimulate latent HIV in primary cells
Brooks, David G., Arlen, Philip A., Gao, Lianying, Kitchen, Christina M. R., Zack, Jerome A.
Eradication of HIV infection depends on the elimination of a small, but stable population of latently infected T cells. After the discontinuation of therapy, activation of latent virus can rekindle...
Ali, Ayub, Lubong, Rachel, Ng, Hwee, Brooks, David G., Zack, Jerome A., Yang, Otto O.
The determinants of CD8+ cytotoxic T-lymphocyte (CTL) antiviral activity against human immunodeficiency virus type 1 (HIV-1) remain poorly defined. Although recent technological advances have...
CD4 on CD8+ T cells directly enhances effector function and is a target for HIV infection
Kitchen, Scott G., Jones, Nicole R., LaForge, Stuart, Whitmire, Jason K., Vu, Bien-Aimee, Galic, Zoran, ...
Costimulation of purified CD8+ T lymphocytes induces de novo expression of CD4, suggesting a previously unrecognized function for this molecule in the immune response. Here, we report that the CD4...
Kitchen, Scott G., Whitmire, Jason K., Jones, Nicole R., Galic, Zoran, Kitchen, Christina M. R., Ahmed, Rafi, ...
CD8+ T lymphocytes play a major role in cellular-mediated immune responses to foreign antigen. We have previously demonstrated that costimulation of purified human CD8+ T cells induces de novo...
Chang, Margaret, Brown, Helen J., Collado-Hidalgo, Alicia, Arevalo, Jesusa M., Galic, Zoran, Symensma, Tonia L., ...
Reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication is mediated by the viral RTA transcription factor, but little is known about the physiological processes controlling...
PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry
Groszer, Matthias, Erickson, Rebecca, Scripture-Adams, Deirdre D., Dougherty, Joseph D., Le Belle, Janel, Zack, Jerome A., ...
Previous studies have demonstrated that a small subpopulation of brain tumor cells share key characteristics with neural stem/progenitor cells in terms of phenotype and behavior. These findings...
Rapid Expression of Human Immunodeficiency Virus following Activation of Latently Infected Cells
Arlen, Philip A., Brooks, David G., Gao, Lian Y., Vatakis, Dimitrios, Brown, Helen J., Zack, Jerome A.
The host cell activation state impacts the nature of human immunodeficiency virus infection. Activated cells facilitate productive infections; quiescent cells enable the virus to enter a latent...
T lineage differentiation from human embryonic stem cells
Galić, Zoran, Kitchen, Scott G., Kacena, Amelia, Subramanian, Aparna, Burke, Bryan, Cortado, Ruth, ...
Harnessing the ability of genetically manipulated human embryonic stem cells (hESC) to differentiate into appropriate lineages could revolutionize medical practice. These cells have the theoretical...
Sullivan, Yvonne B, Landay, Alan L, Zack, Jerome A, Kitchen, Scott G, Al-Harthi, Lena
Aside from an intermediate stage in thymic T-cell development, the expression of CD4 and CD8 is generally thought to be mutually exclusive, associated with helper or cytotoxic T-cell functions,...
Vatakis, Dimitrios N., Bristol, Gregory, Wilkinson, Thomas A., Chow, Samson A., Zack, Jerome A.
Unlike activated T cells, quiescent CD4+ T cells have shown resistance to human immunodeficiency virus (HIV) infection due to a block in the early events of the viral life cycle. To further...
Human Immunodeficiency Virus Bearing a Disrupted Central DNA Flap Is Pathogenic In Vivo▿
Marsden, Matthew D., Zack, Jerome A.
The central DNA flap is an important component of lentiviral vectors, but its significance in the context of wild-type human immunodeficiency virus (HIV) is currently unclear. To address this issue,...
Primary Cell Model for Activation-Inducible Human Immunodeficiency Virus▿
Burke, Bryan, Brown, Helen J., Marsden, Matthew D., Bristol, Gregory, Vatakis, Dimitrios N., Zack, Jerome A.
Quiescent T lymphocytes containing latent human immunodeficiency virus (HIV) provide a long-lived viral reservoir. This reservoir may be the source of active infection that is reinitiated following...