Jeroen P. Roose, Maximilian Diehn, Michael G. Tomlinson, Joseph Lin, Ash A. Alizadeh, David Botstein, ...
In the absence of basal signaling, RAG activity is high at a time during T cell development when it is otherwise normally suppressed.
Jeroen P. Roose, Maximilian Diehn, Michael G. Tomlinson, Joseph Lin, Ash A. Alizadeh, David Botstein, ...
Signal transduction pathways guided by cellular receptors commonly exhibit low-level constitutive signaling in a continuous, ligand-independent manner. The dynamic equilibrium of positive and...
T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression
Roose, Jeroen P, Diehn, Maximilian, Tomlinson, Michael G, Lin, Joseph, Alizadeh, Ash A, Botstein, David, ...
Signal transduction pathways guided by cellular receptors commonly exhibit low-level constitutive signaling in a continuous, ligand-independent manner. The dynamic equilibrium of positive and...
Intramolecular Regulatory Switch in ZAP-70: Analogy with Receptor Tyrosine Kinases
Brdicka, Tomas, Kadlecek, Theresa A., Roose, Jeroen P., Pastuszak, Alexander W., Weiss, Arthur
ZAP-70, a Syk family cytoplasmic protein tyrosine kinase (PTK), is required to couple the activated T-cell antigen receptor (TCR) to downstream signaling pathways. It contains two tandem SH2 domains...
Roose, Jeroen P., Mollenauer, Marianne, Gupta, Vikas A., Stone, James, Weiss, Arthur
Ras GTPases are on/off switches regulating numerous cellular responses by signaling to various effector molecules. In T lymphocytes, Ras can be activated by two Ras exchange factors, SOS and RasGRP1,...
T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression
Roose, Jeroen P, Diehn, Maximilian, Tomlinson, Michael G, Lin, Joseph, Alizadeh, Ash A, Botstein, David, ...
Signal transduction pathways guided by cellular receptors commonly exhibit low-level constitutive signaling in a continuous, ligand-independent manner. The dynamic equilibrium of positive and...
Intramolecular Regulatory Switch in ZAP-70: Analogy with Receptor Tyrosine Kinases
Brdicka, Tomas, Kadlecek, Theresa A., Roose, Jeroen P., Pastuszak, Alexander W., Weiss, Arthur
ZAP-70, a Syk family cytoplasmic protein tyrosine kinase (PTK), is required to couple the activated T-cell antigen receptor (TCR) to downstream signaling pathways. It contains two tandem SH2 domains...
Roose, Jeroen P., Mollenauer, Marianne, Gupta, Vikas A., Stone, James, Weiss, Arthur
Ras GTPases are on/off switches regulating numerous cellular responses by signaling to various effector molecules. In T lymphocytes, Ras can be activated by two Ras exchange factors, SOS and RasGRP1,...
Roose, Jeroen P., Mollenauer, Marianne, Ho, Mary, Kurosaki, Tomohiro, Weiss, Arthur
Ras activation is crucial for lymphocyte development and effector function. Both T and B lymphocytes contain two types of Ras activators: ubiquitously expressed SOS and specifically expressed Ras...