Rines, Daniel R, Gomez-Ferreria, Maria, Zhou, Yingyao, DeJesus, Paul, Grob, Seanna, Batalov, Serge, ...
Abstract Background The mitotic spindle is a complex mechanical apparatus required for accurate segregation of sister chromosomes during mitosis. We designed a genetic screen using automated...
Chao, Sheng-Hao, Walker, John R., Chanda, Sumit K., Gray, Nathanael S., Caldwell, Jeremy S.
Cyclin-dependent kinase inhibitors (CDKIs) have been shown to block human immunodeficiency virus and herpes simplex virus. It is hypothesized that CDKIs block viral replication by inhibiting...
Genome-scale functional profiling of the mammalian AP-1 signaling pathway
Chanda, Sumit K., White, Suhaila, Orth, Anthony P., Reisdorph, Richard, Miraglia, Loren, Thomas, Russell S., ...
Large-scale functional genomics approaches are fundamental to the characterization of mammalian transcriptomes annotated by genome sequencing projects. Although current high-throughput strategies...
Identification of p53 regulators by genome-wide functional analysis
Huang, Qihong, Raya, Angel, DeJesus, Paul, Chao, Sheng-Hao, Quon, Kim C., Caldwell, Jeremy S., ...
The p53 tumor-suppressor protein is a critical mediator of cellular growth arrest and the induction of apoptosis. To identify proteins involved in the modulation of p53 transcriptional activity, a...
Nguyen, Deborah G., Wolff, Karen C., Yin, Hong, Caldwell, Jeremy S., Kuhen, Kelli L.
In order to identify novel proviral host factors involved in human immunodeficiency virus (HIV) infection, we performed a screen of a small interfering RNA (siRNA) library targeting 5,000 genes with...
An efficient rapid system for profiling the cellular activities of molecular libraries
Melnick, Jonathan S., Janes, Jeff, Kim, Sungjoon, Chang, Jim Y., Sipes, Daniel G., Gunderson, Drew, ...
Rapid quantitative methods for characterizing small molecules, peptides, proteins, or RNAs in a broad array of cellular assays would allow one to discover new biological activities associated with...
Chao, Sheng-Hao, Walker, John R., Chanda, Sumit K., Gray, Nathanael S., Caldwell, Jeremy S.
Cyclin-dependent kinase inhibitors (CDKIs) have been shown to block human immunodeficiency virus and herpes simplex virus. It is hypothesized that CDKIs block viral replication by inhibiting...
Genome-scale functional profiling of the mammalian AP-1 signaling pathway
Chanda, Sumit K., White, Suhaila, Orth, Anthony P., Reisdorph, Richard, Miraglia, Loren, Thomas, Russell S., ...
Large-scale functional genomics approaches are fundamental to the characterization of mammalian transcriptomes annotated by genome sequencing projects. Although current high-throughput strategies...
Identification of p53 regulators by genome-wide functional analysis
Huang, Qihong, Raya, Angel, DeJesus, Paul, Chao, Sheng-Hao, Quon, Kim C., Caldwell, Jeremy S., ...
The p53 tumor-suppressor protein is a critical mediator of cellular growth arrest and the induction of apoptosis. To identify proteins involved in the modulation of p53 transcriptional activity, a...
Nguyen, Deborah G., Wolff, Karen C., Yin, Hong, Caldwell, Jeremy S., Kuhen, Kelli L.
In order to identify novel proviral host factors involved in human immunodeficiency virus (HIV) infection, we performed a screen of a small interfering RNA (siRNA) library targeting 5,000 genes with...
An efficient rapid system for profiling the cellular activities of molecular libraries
Melnick, Jonathan S., Janes, Jeff, Kim, Sungjoon, Chang, Jim Y., Sipes, Daniel G., Gunderson, Drew, ...
Rapid quantitative methods for characterizing small molecules, peptides, proteins, or RNAs in a broad array of cellular assays would allow one to discover new biological activities associated with...
Rines, Daniel R, Gomez-Ferreria, Maria Ana, Zhou, Yingyao, DeJesus, Paul, Grob, Seanna, Batalov, Serge, ...
A loss-of-function screen for siRNAs that arrest human cells in metaphase reveals genes involved in mitotic spindle integrity.