Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin (2005)
Sennello, Joseph A, Fayad, Raja, Morris, Alison M, Eckel, Robert H, Asilmaz, Esra, Montez, Jason, ...
Zhihua Han, Simon C. Heath, Dvora Shmulewitz, Wentian Li, Steve B. Auerbach, Maude L. Blundell, ...
d BP levels, 2) the CYP7a/BsaI with apo AI and BMI levels. We also confirmed the following associations: 1) the apo AII/MspI with Tg level; 2) the apo CIII/SstI with Tg, TC, and apo B levels; 3) the...
In a cross-sectional study, a stratified randomly selected sample of 120 sixteen year old adolescents were assessed for suicidal ideation. African-American, Hispanic, and White groups of forty male...
Regulation of liver gene expression. (1986)
Thesis (Ph. D.)--Rockefeller University.
UMI Number: 972721.
Fei, Hong, Okano, Hirotaka J., Li, Cai, Lee, Gwo-Hwa, Zhao, Connie, Darnell, Robert, ...
Leptin’s effects are mediated by interactions with a receptor that is alternatively spliced, resulting in at least five different murine forms: Ob-Ra, Ob-Rb, Ob-Rc, Ob-Rd, and Ob-Re. A mutation in...
Abnormal regulation of the leptin gene in the pathogenesis of obesity
Ioffe, Ella, Moon, Byoung, Connolly, Eileen, Friedman, Jeffrey M.
A subset of obese humans has relatively low plasma levels of leptin. This finding has suggested that in some cases abnormal regulation of the leptin gene in adipose tissue is etiologic in the...
Leptin exerts its weight-reducing effects by binding to its receptor and activating signal transduction in hypothalamic neurons and other cell types. To identify the components of the leptin signal...
Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
Halaas, Jeffrey L., Boozer, Carol, Blair-West, John, Fidahusein, Naseem, Denton, Derek A., Friedman, Jeffrey M.
Recent data have identified leptin as an afferent signal in a negative-feedback loop regulating the mass of the adipose tissue. High leptin levels are observed in obese humans and rodents, suggesting...
Weinstock, Peter H., Levak-Frank, Sanja, Hudgins, Lisa C., Radner, Herbert, Friedman, Jeffrey M., Zechner, Rudolf, ...
Lipoprotein lipase (LPL) is the rate-limiting enzyme for the import of triglyceride-derived fatty acids by muscle, for utilization, and adipose tissue (AT), for storage. Relative ratios of LPL...
Yoon, J. Cliff, Chickering, Troy W., Rosen, Evan D., Dussault, Barry, Qin, Yubin, Soukas, Alexander, ...
The nuclear receptor peroxisome proliferator-activated receptor γ regulates adipose differentiation and systemic insulin signaling via ligand-dependent transcriptional activation of target genes....
Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity
Ntambi, James M., Miyazaki, Makoto, Stoehr, Jonathan P., Lan, Hong, Kendziorski, Christina M., Yandell, Brian S., ...
Stearoyl–CoA desaturase (SCD) is a central lipogenic enzyme catalyzing the synthesis of monounsaturated fatty acids, mainly oleate (C18:1) and palmitoleate (C16:1), which are components of membrane...
Ishii, Makoto, Fei, Hong, Friedman, Jeffrey M.
Gold-thioglucose (GTG) induces lesions in the ventromedial nucleus of the hypothalamus, resulting in hyperphagia and obesity. To identify genes involved in the hypothalamic regulation of energy...
Selective deletion of leptin receptor in neurons leads to obesity
Cohen, Paul, Zhao, Connie, Cai, Xiaoli, Montez, Jason M., Rohani, S. Christy, Feinstein, Paul, ...
Animals with mutations in the leptin receptor (ObR) exhibit an obese phenotype that is indistinguishable from that of leptin deficient ob/ob mice. ObR is expressed in many tissues, including brain,...
Abnormal osmotic regulation in trpv4-/- mice
Liedtke, Wolfgang, Friedman, Jeffrey M.
Osmotic homeostasis is one of the most aggressively defended physiological parameters in vertebrates. However, the molecular mechanisms underlying osmotic regulation are poorly understood. The...
Liedtke, Wolfgang, Tobin, David M., Bargmann, Cornelia I., Friedman, Jeffrey M.
All animals detect osmotic and mechanical stimuli, but the molecular basis for these responses is incompletely understood. The vertebrate transient receptor potential channel vanilloid subfamily 4...
Winick, Jeffrey D., Friedman, Jeffrey M.
Twin studies, adoption studies, and studies of familial aggregation indicate that obesity has a genetic component. Whereas, the genetic factors predisposing to obesity have been elucidated for...
Leptin-specific patterns of gene expression in white adipose tissue
Soukas, Alexander, Cohen, Paul, Socci, Nicholas D., Friedman, Jeffrey M.
Leptin is a hormone that regulates body weight by decreasing food intake and increasing energy expenditure. ob/ob mice carry leptin mutations and are obese and hyperphagic. Leptin administration to...
Site and mechanism of leptin action in a rodent form of congenital lipodystrophy
Asilmaz, Esra, Cohen, Paul, Miyazaki, Makoto, Dobrzyn, Pawel, Ueki, Kohjiro, Fayzikhodjaeva, Gulnorakhon, ...
Lipodystrophy is characterized by the complete or partial absence of adipose tissue, insulin resistance, hepatic steatosis, and leptin deficiency. Here, we show that low-dose central leptin corrects...
Dobrzyn, Pawel, Dobrzyn, Agnieszka, Miyazaki, Makoto, Cohen, Paul, Asilmaz, Esra, Hardie, D. Grahame, ...
Stearoyl-CoA desaturase (SCD) catalyzes the rate-limiting step in the biosynthesis of monounsaturated fatty acids. Mice with a targeted disruption of the SCD1 isoform have reduced body adiposity,...
Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal
Montez, Jason M., Soukas, Alex, Asilmaz, Esra, Fayzikhodjaeva, Gulnorakhon, Fantuzzi, Giamila, Friedman, Jeffrey M.
Food restriction and weight loss result in reduced plasma leptin, which is associated with a pleiotropic biologic response. However, because weight loss itself is also associated with changes in...
Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein.
Haqq, Andrea M, René, Patricia, Kishi, Toshiro, Khong, Kathy, Lee, Charlotte E, Liu, Hongyan, ...
The gene dosage effect of the MC4-R (melanocortin 4 receptor) on obesity suggests that regulation of MC4-R expression and function is critically important to the central control of energy...
Shmulewitz, Dvora, Heath, Simon C., Blundell, Maude L., Han, Zhihua, Sharma, Ratnendra, Salit, Jacqueline, ...
Obesity, diabetes, hypertension, and heart disease are highly heritable conditions that in aggregate are the major causes of morbidity and mortality in the developed world and are growing problems in...
Fei, Hong, Okano, Hirotaka J., Li, Cai, Lee, Gwo-Hwa, Zhao, Connie, Darnell, Robert, ...
Leptin’s effects are mediated by interactions with a receptor that is alternatively spliced, resulting in at least five different murine forms: Ob-Ra, Ob-Rb, Ob-Rc, Ob-Rd, and Ob-Re. A mutation in...
Abnormal regulation of the leptin gene in the pathogenesis of obesity
Ioffe, Ella, Moon, Byoung, Connolly, Eileen, Friedman, Jeffrey M.
A subset of obese humans has relatively low plasma levels of leptin. This finding has suggested that in some cases abnormal regulation of the leptin gene in adipose tissue is etiologic in the...
Leptin exerts its weight-reducing effects by binding to its receptor and activating signal transduction in hypothalamic neurons and other cell types. To identify the components of the leptin signal...
Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
Halaas, Jeffrey L., Boozer, Carol, Blair-West, John, Fidahusein, Naseem, Denton, Derek A., Friedman, Jeffrey M.
Recent data have identified leptin as an afferent signal in a negative-feedback loop regulating the mass of the adipose tissue. High leptin levels are observed in obese humans and rodents, suggesting...
Weinstock, Peter H., Levak-Frank, Sanja, Hudgins, Lisa C., Radner, Herbert, Friedman, Jeffrey M., Zechner, Rudolf, ...
Lipoprotein lipase (LPL) is the rate-limiting enzyme for the import of triglyceride-derived fatty acids by muscle, for utilization, and adipose tissue (AT), for storage. Relative ratios of LPL...
Yoon, J. Cliff, Chickering, Troy W., Rosen, Evan D., Dussault, Barry, Qin, Yubin, Soukas, Alexander, ...
The nuclear receptor peroxisome proliferator-activated receptor γ regulates adipose differentiation and systemic insulin signaling via ligand-dependent transcriptional activation of target genes....
Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity
Ntambi, James M., Miyazaki, Makoto, Stoehr, Jonathan P., Lan, Hong, Kendziorski, Christina M., Yandell, Brian S., ...
Stearoyl–CoA desaturase (SCD) is a central lipogenic enzyme catalyzing the synthesis of monounsaturated fatty acids, mainly oleate (C18:1) and palmitoleate (C16:1), which are components of membrane...
Ishii, Makoto, Fei, Hong, Friedman, Jeffrey M.
Gold-thioglucose (GTG) induces lesions in the ventromedial nucleus of the hypothalamus, resulting in hyperphagia and obesity. To identify genes involved in the hypothalamic regulation of energy...
Selective deletion of leptin receptor in neurons leads to obesity
Cohen, Paul, Zhao, Connie, Cai, Xiaoli, Montez, Jason M., Rohani, S. Christy, Feinstein, Paul, ...
Animals with mutations in the leptin receptor (ObR) exhibit an obese phenotype that is indistinguishable from that of leptin deficient ob/ob mice. ObR is expressed in many tissues, including brain,...
Abnormal osmotic regulation in trpv4-/- mice
Liedtke, Wolfgang, Friedman, Jeffrey M.
Osmotic homeostasis is one of the most aggressively defended physiological parameters in vertebrates. However, the molecular mechanisms underlying osmotic regulation are poorly understood. The...
Liedtke, Wolfgang, Tobin, David M., Bargmann, Cornelia I., Friedman, Jeffrey M.
All animals detect osmotic and mechanical stimuli, but the molecular basis for these responses is incompletely understood. The vertebrate transient receptor potential channel vanilloid subfamily 4...
Winick, Jeffrey D., Friedman, Jeffrey M.
Twin studies, adoption studies, and studies of familial aggregation indicate that obesity has a genetic component. Whereas, the genetic factors predisposing to obesity have been elucidated for...
Leptin-specific patterns of gene expression in white adipose tissue
Soukas, Alexander, Cohen, Paul, Socci, Nicholas D., Friedman, Jeffrey M.
Leptin is a hormone that regulates body weight by decreasing food intake and increasing energy expenditure. ob/ob mice carry leptin mutations and are obese and hyperphagic. Leptin administration to...
Site and mechanism of leptin action in a rodent form of congenital lipodystrophy
Asilmaz, Esra, Cohen, Paul, Miyazaki, Makoto, Dobrzyn, Pawel, Ueki, Kohjiro, Fayzikhodjaeva, Gulnorakhon, ...
Lipodystrophy is characterized by the complete or partial absence of adipose tissue, insulin resistance, hepatic steatosis, and leptin deficiency. Here, we show that low-dose central leptin corrects...
Dobrzyn, Pawel, Dobrzyn, Agnieszka, Miyazaki, Makoto, Cohen, Paul, Asilmaz, Esra, Hardie, D. Grahame, ...
Stearoyl-CoA desaturase (SCD) catalyzes the rate-limiting step in the biosynthesis of monounsaturated fatty acids. Mice with a targeted disruption of the SCD1 isoform have reduced body adiposity,...
Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal
Montez, Jason M., Soukas, Alex, Asilmaz, Esra, Fayzikhodjaeva, Gulnorakhon, Fantuzzi, Giamila, Friedman, Jeffrey M.
Food restriction and weight loss result in reduced plasma leptin, which is associated with a pleiotropic biologic response. However, because weight loss itself is also associated with changes in...
Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein.
Haqq, Andrea M, René, Patricia, Kishi, Toshiro, Khong, Kathy, Lee, Charlotte E, Liu, Hongyan, ...
The gene dosage effect of the MC4-R (melanocortin 4 receptor) on obesity suggests that regulation of MC4-R expression and function is critically important to the central control of energy...
Shmulewitz, Dvora, Heath, Simon C., Blundell, Maude L., Han, Zhihua, Sharma, Ratnendra, Salit, Jacqueline, ...
Obesity, diabetes, hypertension, and heart disease are highly heritable conditions that in aggregate are the major causes of morbidity and mortality in the developed world and are growing problems in...