Jeffery A. Porter

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists (2002)

Frank-Kamenetsky, Maria, Zhang, Xiaoyan M, Bottega, Steve, Guicherit, Oivin, Wichterle, Hynek, Dudek, Henryk, ...

Abstract Background The Hedgehog (Hh) signaling pathway is vital to animal development as it mediates the differentiation of multiple cell types during embryogenesis. In adults, Hh signaling can be...

Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched

Fuse, Naoyuki, Maiti, Tapan, Wang, Baolin, Porter, Jeffery A., Hall, Traci M. Tanaka, Leahy, Daniel J., ...

The amino-terminal signaling domain of the Sonic hedgehog secreted protein (Shh-N), which derives from the Shh precursor through an autoprocessing reaction mediated by the carboxyl-terminal domain,...

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

Frank-Kamenetsky, Maria, Zhang, Xiaoyan M, Bottega, Steve, Guicherit, Oivin, Wichterle, Hynek, Dudek, Henryk, ...

Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions

Williams, Juliet A., Guicherit, Oivin M., Zaharian, Beatrice I., Xu, Yin, Chai, Ling, Wichterle, Hynek, ...

The link between basal cell carcinoma (BCC) and aberrant activation of the Hedgehog (Hh) signaling pathway has been well established in humans and in mouse models. Here we report the development of...

Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched

Fuse, Naoyuki, Maiti, Tapan, Wang, Baolin, Porter, Jeffery A., Hall, Traci M. Tanaka, Leahy, Daniel J., ...

The amino-terminal signaling domain of the Sonic hedgehog secreted protein (Shh-N), which derives from the Shh precursor through an autoprocessing reaction mediated by the carboxyl-terminal domain,...

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

Frank-Kamenetsky, Maria, Zhang, Xiaoyan M, Bottega, Steve, Guicherit, Oivin, Wichterle, Hynek, Dudek, Henryk, ...

Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions

Williams, Juliet A., Guicherit, Oivin M., Zaharian, Beatrice I., Xu, Yin, Chai, Ling, Wichterle, Hynek, ...

The link between basal cell carcinoma (BCC) and aberrant activation of the Hedgehog (Hh) signaling pathway has been well established in humans and in mouse models. Here we report the development of...