REC, Drosophila MCM8, Drives Formation of Meiotic Crossovers (2005)
Hunter L. Blanton, Sarah J. Radford, Susan McMahan, Hutton M. Kearney, Joseph G. Ibrahim, Jeff Sekelsky
Crossovers ensure the accurate segregation of homologous chromosomes from one another during meiosis. Here, we describe the identity and function of the Drosophila melanogaster gene recombination...
REC, Drosophila MCM8, Drives Formation of Meiotic Crossovers (2005)
Hunter Blanton, Sarah Radford, Susan McMahan, Hutton Kearney, Joseph Ibrahim, Jeff Sekelsky
Crossovers ensure the accurate segregation of homologous chromosomes from one another during meiosis. Here, we describe the identity and function of the Drosophila melanogaster gene recombination...
REC, Drosophila MCM8, Drives Formation of Meiotic Crossovers
Blanton, Hunter L, Radford, Sarah J, McMahan, Susan, Kearney, Hutton M, Ibrahim, Joseph G, Sekelsky, Jeff
Crossovers ensure the accurate segregation of homologous chromosomes from one another during meiosis. Here, we describe the identity and function of the Drosophila melanogaster gene recombination...
Drosophila ERCC1 is required for a subset of MEI-9-dependent meiotic crossovers
Radford, Sarah J., Goley, Elizabeth, Baxter, Kimberly, McMahan, Susan, Sekelsky, Jeff
Drosophila MEI-9 is the catalytic subunit of a DNA structure-specific endonuclease required for nucleotide excision repair (NER). The enzymatic activity of this endonuclease during NER requires the...
Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR.
Laurençon, Anne, Purdy, Amanda, Sekelsky, Jeff, Hawley, R Scott, Su, Tin Tin
ATM/ATR kinases act as signal transducers in eukaryotic DNA damage and replication checkpoints. Mutations in ATM/ATR homologs have pleiotropic effects that range from sterility to increased killing...
REC, Drosophila MCM8, Drives Formation of Meiotic Crossovers
Blanton, Hunter L, Radford, Sarah J, McMahan, Susan, Kearney, Hutton M, Ibrahim, Joseph G, Sekelsky, Jeff
Crossovers ensure the accurate segregation of homologous chromosomes from one another during meiosis. Here, we describe the identity and function of the Drosophila melanogaster gene recombination...
Drosophila ERCC1 Is Required for a Subset of MEI-9-Dependent Meiotic Crossovers
Radford, Sarah J., Goley, Elizabeth, Baxter, Kimberly, McMahan, Susan, Sekelsky, Jeff
Drosophila MEI-9 is the catalytic subunit of a DNA structure-specific endonuclease required for nucleotide excision repair (NER). The enzymatic activity of this endonuclease during NER requires the...
Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR.
Laurençon, Anne, Purdy, Amanda, Sekelsky, Jeff, Hawley, R Scott, Su, Tin Tin
ATM/ATR kinases act as signal transducers in eukaryotic DNA damage and replication checkpoints. Mutations in ATM/ATR homologs have pleiotropic effects that range from sterility to increased killing...
Drosophila ATR in Double-Strand Break Repair
LaRocque, Jeannine R., Jaklevic, Burnley, Su, Tin Tin, Sekelsky, Jeff
The ability of a cell to sense and respond to DNA damage is essential for genome stability. An important aspect of the response is arrest of the cell cycle, presumably to allow time for repair....
Heteroduplex DNA in Meiotic Recombination in Drosophila mei-9 Mutants
Radford, Sarah J., McMahan, Susan, Blanton, Hunter L., Sekelsky, Jeff
Meiotic recombination gives rise to crossovers, which are required in most organisms for the faithful segregation of homologous chromosomes during meiotic cell division. Characterization of...
Meiotic Recombination in Drosophila Msh6 Mutants Yields Discontinuous Gene Conversion Tracts
Radford, Sarah J., Sabourin, Mathilde M., McMahan, Susan, Sekelsky, Jeff
Crossovers (COs) generated through meiotic recombination are important for the correct segregation of homologous chromosomes during meiosis. Several models describing the molecular mechanism of...
LaRocque, Jeannine R., Dougherty, Diana L., Hussain, Sumreen K., Sekelsky, Jeff
The ability to respond to DNA damage and incomplete replication ensures proper duplication and stability of the genome. Two checkpoint kinases, ATM and ATR, are required for DNA damage and...
Multiple Functions of Drosophila BLM Helicase in Maintenance of Genome Stability
McVey, Mitch, Andersen, Sabrina L., Broze, Yuri, Sekelsky, Jeff
Bloom Syndrome, a rare human disorder characterized by genomic instability and predisposition to cancer, is caused by mutation of BLM, which encodes a RecQ-family DNA helicase. The Drosophila...
Trowbridge, Kirsten, McKim, Kim, Brill, Steven J., Sekelsky, Jeff
Mus81-Mms4 (Mus81-Eme1 in some species) is a heterodimeric DNA structure-specific endonuclease that has been implicated in meiotic recombination and processing of damaged replication forks in fungi....