Jeannine R. LaRocque

Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion

McVey, Mitch, LaRocque, Jeannine R., Adams, Melissa D., Sekelsky, Jeff J.

Bloom syndrome is a rare disorder associated with cancer predisposition and genomic instability and is caused by loss of the RecQ helicase BLM. The Drosophila ortholog of BLM (DmBlm) is required for...

Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion

McVey, Mitch, LaRocque, Jeannine R., Adams, Melissa D., Sekelsky, Jeff J.

Bloom syndrome is a rare disorder associated with cancer predisposition and genomic instability and is caused by loss of the RecQ helicase BLM. The Drosophila ortholog of BLM (DmBlm) is required for...

Drosophila ATR in Double-Strand Break Repair

LaRocque, Jeannine R., Jaklevic, Burnley, Su, Tin Tin, Sekelsky, Jeff

The ability of a cell to sense and respond to DNA damage is essential for genome stability. An important aspect of the response is arrest of the cell cycle, presumably to allow time for repair....

Reducing DNA Polymerase α in the Absence of Drosophila ATR Leads to P53-Dependent Apoptosis and Developmental Defects

LaRocque, Jeannine R., Dougherty, Diana L., Hussain, Sumreen K., Sekelsky, Jeff

The ability to respond to DNA damage and incomplete replication ensures proper duplication and stability of the genome. Two checkpoint kinases, ATM and ATR, are required for DNA damage and...