Jean-Pierre Gorvel

Brucella Control of Dendritic Cell Maturation Is Dependent on the TIR-Containing Protein Btp1 (2008)

Suzana P. Salcedo, María Ines Marchesini, Hugues Lelouard, Emilie Fugier, Gilles Jolly, Stephanie Balor, ...

Brucella is an intracellular pathogen able to persist for long periods of time within the host and establish a chronic disease. We show that soon after Brucella inoculation in intestinal loops,...

Nanobacteria Are Mineralo Fetuin Complexes (2008)

Didier Raoult, Michel Drancourt, Saïd Azza, Claude Nappez, Régis Guieu, Jean-Marc Rolain, ...

“Nanobacteria” are nanometer-scale spherical and ovoid particles which have spurred one of the biggest controversies in modern microbiology. Their biological nature has been severely challenged...

Interaction of Brucella abortus Lipopolysaccharide with Major Histocompatibility Complex Class II Molecules in B Lymphocytes

Forestier, Claire, Moreno, Edgardo, Méresse, Stéphane, Phalipon, Armelle, Olive, Daniel, Sansonetti, Philippe, ...

Lipopolysaccharide (LPS), a major amphiphilic molecule located at the outer membrane of gram-negative bacteria, is a potent antigen known to induce specific humoral immune responses in infected...

The Outer Membrane of Brucella ovis Shows Increased Permeability to Hydrophobic Probes and Is More Susceptible to Cationic Peptides than Are the Outer Membranes of Mutant Rough Brucella abortus Strains

Freer, Enrique, Pizarro-Cerdá, Javier, Weintraub, Andrej, Bengoechea, José-Antonio, Moriyón, Ignacio, Hultenby, Kjell, ...

The permeability of the outer membrane (OM) to hydrophobic probes and its susceptibility to bactericidal cationic peptides were investigated for natural rough Brucella ovis and for mutant rough...

Virulent Brucella abortus Prevents Lysosome Fusion and Is Distributed within Autophagosome-Like Compartments

Pizarro-Cerdá, Javier, Moreno, Edgardo, Sanguedolce, Veronique, Mege, Jean-Louis, Gorvel, Jean-Pierre

Virulent and attenuated Brucella abortus strains attach to and penetrate nonprofessional phagocytic HeLa cells. Compared to pathogenic Brucella, the attenuated strain 19 hardly replicates within...

Brucella abortus Transits through the Autophagic Pathway and Replicates in the Endoplasmic Reticulum of Nonprofessional Phagocytes

Pizarro-Cerdá, Javier, Méresse, Stéphane, Parton, Robert G., Van Der Goot, Gisou, Sola-Landa, Alberto, Lopez-Goñi, Ignacio, ...

Brucella abortus is an intracellular pathogen that replicates within a membrane-bounded compartment. In this study, we have examined the intracellular pathway of the virulent B. abortus strain 2308...

The Cytoplasmic Tail of Invariant Chain Regulates Endosome Fusion and Morphology

Nordeng, Tommy W., Gregers, Tone F., Kongsvik, Thomas Lasker, Méresse, Stéphane, Gorvel, Jean-Pierre, Jourdan, Fabrice, ...

The major histocompatibility complex class II associated invariant chain (Ii) has been shown to inhibit endocytic transport and to increase the size of endosomes. We have recently found that this...

Survival of Tropheryma whipplei, the Agent of Whipple's Disease, Requires Phagosome Acidification

Ghigo, Eric, Capo, Christian, Aurouze, Marianne, Tung, Ching-Hsuan, Gorvel, Jean-Pierre, Raoult, Didier, ...

Tropheryma whipplei was established as the agent of Whipple's disease in 2000, but the mechanisms by which it survives within host cells are still unknown. We show here that T. whipplei survives...

Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening

Kurz, C.Léopold, Chauvet, Sophie, Andrès, Emmanuel, Aurouze, Marianne, Vallet, Isabelle, Michel, Gérard P.F., ...

The human opportunistic pathogen Serratia marcescens is a bacterium with a broad host range, and represents a growing problem for public health. Serratia marcescens kills Caenorhabditis elegans after...

Brucella coopts the small GTPase Sar1 for intracellular replication

Celli, Jean, Salcedo, Suzana P., Gorvel, Jean-Pierre

The pathogen Brucella abortus resides inside macrophages within a unique, replication-permissive organelle that is derived from the endoplasmic reticulum (ER). Although dependent on the Brucella type...

Bactericidal and Antiendotoxic Properties of Short Cationic Peptides Derived from a Snake Venom Lys49 Phospholipase A2

Santamaría, Carlos, Larios, Silda, Quirós, Steve, Pizarro-Cerda, Javier, Gorvel, Jean-Pierre, Lomonte, Bruno, ...

The activities of short synthetic, nonhemolytic peptides derived from the C-terminal region of myotoxin II, a catalytically inactive phospholipase A2 homologue present in the venom of the snake...

Interaction of Brucella abortus Lipopolysaccharide with Major Histocompatibility Complex Class II Molecules in B Lymphocytes

Forestier, Claire, Moreno, Edgardo, Méresse, Stéphane, Phalipon, Armelle, Olive, Daniel, Sansonetti, Philippe, ...

Lipopolysaccharide (LPS), a major amphiphilic molecule located at the outer membrane of gram-negative bacteria, is a potent antigen known to induce specific humoral immune responses in infected...

The Outer Membrane of Brucella ovis Shows Increased Permeability to Hydrophobic Probes and Is More Susceptible to Cationic Peptides than Are the Outer Membranes of Mutant Rough Brucella abortus Strains

Freer, Enrique, Pizarro-Cerdá, Javier, Weintraub, Andrej, Bengoechea, José-Antonio, Moriyón, Ignacio, Hultenby, Kjell, ...

The permeability of the outer membrane (OM) to hydrophobic probes and its susceptibility to bactericidal cationic peptides were investigated for natural rough Brucella ovis and for mutant rough...

Virulent Brucella abortus Prevents Lysosome Fusion and Is Distributed within Autophagosome-Like Compartments

Pizarro-Cerdá, Javier, Moreno, Edgardo, Sanguedolce, Veronique, Mege, Jean-Louis, Gorvel, Jean-Pierre

Virulent and attenuated Brucella abortus strains attach to and penetrate nonprofessional phagocytic HeLa cells. Compared to pathogenic Brucella, the attenuated strain 19 hardly replicates within...

Brucella abortus Transits through the Autophagic Pathway and Replicates in the Endoplasmic Reticulum of Nonprofessional Phagocytes

Pizarro-Cerdá, Javier, Méresse, Stéphane, Parton, Robert G., Van Der Goot, Gisou, Sola-Landa, Alberto, Lopez-Goñi, Ignacio, ...

Brucella abortus is an intracellular pathogen that replicates within a membrane-bounded compartment. In this study, we have examined the intracellular pathway of the virulent B. abortus strain 2308...

The Cytoplasmic Tail of Invariant Chain Regulates Endosome Fusion and Morphology

Nordeng, Tommy W., Gregers, Tone F., Kongsvik, Thomas Lasker, Méresse, Stéphane, Gorvel, Jean-Pierre, Jourdan, Fabrice, ...

The major histocompatibility complex class II associated invariant chain (Ii) has been shown to inhibit endocytic transport and to increase the size of endosomes. We have recently found that this...

Survival of Tropheryma whipplei, the Agent of Whipple's Disease, Requires Phagosome Acidification

Ghigo, Eric, Capo, Christian, Aurouze, Marianne, Tung, Ching-Hsuan, Gorvel, Jean-Pierre, Raoult, Didier, ...

Tropheryma whipplei was established as the agent of Whipple's disease in 2000, but the mechanisms by which it survives within host cells are still unknown. We show here that T. whipplei survives...

Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening

Kurz, C.Léopold, Chauvet, Sophie, Andrès, Emmanuel, Aurouze, Marianne, Vallet, Isabelle, Michel, Gérard P.F., ...

The human opportunistic pathogen Serratia marcescens is a bacterium with a broad host range, and represents a growing problem for public health. Serratia marcescens kills Caenorhabditis elegans after...

Brucella coopts the small GTPase Sar1 for intracellular replication

Celli, Jean, Salcedo, Suzana P., Gorvel, Jean-Pierre

The pathogen Brucella abortus resides inside macrophages within a unique, replication-permissive organelle that is derived from the endoplasmic reticulum (ER). Although dependent on the Brucella type...

Bactericidal and Antiendotoxic Properties of Short Cationic Peptides Derived from a Snake Venom Lys49 Phospholipase A2

Santamaría, Carlos, Larios, Silda, Quirós, Steve, Pizarro-Cerda, Javier, Gorvel, Jean-Pierre, Lomonte, Bruno, ...

The activities of short synthetic, nonhemolytic peptides derived from the C-terminal region of myotoxin II, a catalytically inactive phospholipase A2 homologue present in the venom of the snake...

The Salmonella effector protein PipB2 is a linker for kinesin-1

Henry, Thomas, Couillault, Carole, Rockenfeller, Patrick, Boucrot, Emmanuel, Dumont, Audrey, Schroeder, Nina, ...

Understanding the mechanisms of Salmonella virulence is an important challenge. The capacity of this intracellular bacterial pathogen to cause diseases depends on the expression of virulence factors...

Mimivirus Giant Particles Incorporate a Large Fraction of Anonymous and Unique Gene Products▿ †

Renesto, Patricia, Abergel, Chantal, Decloquement, Philippe, Moinier, Danielle, Azza, Saïd, Ogata, Hiroyuki, ...

Acanthamoeba polyphaga mimivirus is the largest known virus in both particle size and genome complexity. Its 1.2-Mb genome encodes 911 proteins, among which only 298 have predicted functions. The...

The Translocated Salmonella Effector Proteins SseF and SseG Interact and Are Required To Establish an Intracellular Replication Niche▿

Deiwick, Jörg, Salcedo, Suzana P., Boucrot, Emmanuel, Gilliland, Sarah M., Henry, Thomas, Petermann, Nele, ...

The facultative intracellular pathogen Salmonella enterica causes a variety of diseases, including gastroenteritis and typhoid fever. Inside epithelial cells, Salmonella replicates in vacuoles, which...

Brucella Evades Macrophage Killing via VirB-dependent Sustained Interactions with the Endoplasmic Reticulum

Celli, Jean, De Chastellier, Chantal, Franchini, Don-Marc, Pizarro-Cerda, Javier, Moreno, Edgardo, Gorvel, Jean-Pierre

The intracellular pathogen Brucella is the causative agent of brucellosis, a worldwide zoonosis that affects mammals, including humans. Essential to Brucella virulence is its ability to survive and...

Brucella Control of Dendritic Cell Maturation Is Dependent on the TIR-Containing Protein Btp1

Salcedo, Suzana P, Marchesini, María Ines, Lelouard, Hugues, Fugier, Emilie, Jolly, Gilles, Balor, Stephanie, ...

Brucella is an intracellular pathogen able to persist for long periods of time within the host and establish a chronic disease. We show that soon after Brucella inoculation in intestinal loops,...

Nanobacteria Are Mineralo Fetuin Complexes

Raoult, Didier, Drancourt, Michel, Azza, Saïd, Nappez, Claude, Guieu, Régis, Rolain, Jean-Marc, ...

“Nanobacteria” are nanometer-scale spherical and ovoid particles which have spurred one of the biggest controversies in modern microbiology. Their biological nature has been severely challenged...

Trafficking of Shigella Lipopolysaccharide in Polarized Intestinal Epithelial Cells

Beatty, Wandy L., Méresse, Stéphane, Gounon, Pierre, Davoust, Jean, Mounier, Joëlle, Sansonetti, Philippe J., ...

Bacterial lipopolysaccharide (LPS) at the apical surface of polarized intestinal epithelial cells was previously shown to be transported from the apical to the basolateral pole of the epithelium...