Jean-Paul Mira

Risk factors for post-ICU red blood cell transfusion: a prospective study (2006)

Marque, Sophie, Cariou, Alain, Chiche, Jean-Daniel, Mallet, Vincent, Pene, Frédéric, Mira, Jean-Paul, ...

Abstract Introduction Factors predictive of the need for red blood cell (RBC) transfusion in the intensive care unit (ICU) have been identified, but risk factors for transfusion after ICU discharge...

Lemierre's syndrome and genetic polymorphisms: a case report. (2006)

Constantin, Jean-Michel, Mira, Jean-Paul, Guerin, Renaud, Cayot-Constantin, Sophie, Lesens, Olivier, Gourdon, Florence, ...

BACKGROUND: Lemierre's syndrome presents a classic clinical picture, the pathophysiology of which remains obscure. Attempts have been made to trace genetic predispositions that modify the host...

Lemierre's syndrome and genetic polymorphisms: a case report. (2006)

Constantin, Jean-Michel, Mira, Jean-Paul, Guerin, Renaud, Cayot-Constantin, Sophie, Lesens, Olivier, Gourdon, Florence, ...

BACKGROUND: Lemierre's syndrome presents a classic clinical picture, the pathophysiology of which remains obscure. Attempts have been made to trace genetic predispositions that modify the host...

Determinants of mortality for adults with cystic fibrosis admitted in Intensive Care Unit: a multicenter study. (2006)

Texereau, Joëlle, Jamal, Dany, Choukroun, Gérald, Burgel, Pierre-Régis, Diehl, Jean-Luc, Rabbat, Antoine, ...

BACKGROUND: Intensive care unit (ICU) admission of adults with cystic fibrosis (CF) is controversial because of poor outcome. This appraisal needs re-evaluation following recent changes in both CF...

Determinants of mortality for adults with cystic fibrosis admitted in Intensive Care Unit: a multicenter study. (2006)

Texereau, Joëlle, Jamal, Dany, Choukroun, Gérald, Burgel, Pierre-Régis, Diehl, Jean-Luc, Rabbat, Antoine, ...

BACKGROUND: Intensive care unit (ICU) admission of adults with cystic fibrosis (CF) is controversial because of poor outcome. This appraisal needs re-evaluation following recent changes in both CF...

Lemierre's syndrome and genetic polymorphisms: a case report (2006)

Constantin, Jean-Michel, Mira, Jean-Paul, Guerin, Renaud, Cayot-Constantin, Sophie, Lesens, Olivier, Gourdon, Florence, ...

Abstract Background Lemierre's syndrome presents a classic clinical picture, the pathophysiology of which remains obscure. Attempts have been made to trace genetic predispositions that modify the...

Determinants of mortality for adults with cystic fibrosis admitted in Intensive Care Unit: a multicenter study (2006)

Texereau, Joëlle, Jamal, Dany, Choukroun, Gérald, Burgel, Pierre-Régis, Diehl, Jean-Luc, Rabbat, Antoine, ...

Abstract Background Intensive care unit (ICU) admission of adults with cystic fibrosis (CF) is controversial because of poor outcome. This appraisal needs re-evaluation following recent changes in...

Determinants of mortality for adults with cystic fibrosis admitted in Intensive Care Unit: a multicenter study. (2006)

Texereau, Joëlle, Jamal, Dany, Choukroun, Gérald, Burgel, Pierre-Régis, Diehl, Jean-Luc, Rabbat, Antoine, ...

BACKGROUND: Intensive care unit (ICU) admission of adults with cystic fibrosis (CF) is controversial because of poor outcome. This appraisal needs re-evaluation following recent changes in both CF...

Lemierre's syndrome and genetic polymorphisms: a case report. (2006)

Constantin, Jean-Michel, Mira, Jean-Paul, Guerin, Renaud, Cayot-Constantin, Sophie, Lesens, Olivier, Gourdon, Florence, ...

ABSTRACT: BACKGROUND: Lemierre's syndrome presents a classic clinical picture, the pathophysiology of which remains obscure. Attempts have been made to trace genetic predispositions that modify the...

Bench-to-bedside review: Severe lactic acidosis in HIV patients treated with nucleoside analogue reverse transcriptase inhibitors (2003)

Claessens, Yann-Erick, Chiche, Jean-Daniel, Mira, Jean-Paul, Cariou, Alain

Abstract Nucleoside reverse transcriptase inhibitors (NRTIs) are effective antiretroviral therapy for the treatment of HIV-infected patients. NRTIs can induce mitochondrial impairment that leads to a...

Bench-to-bedside review: Fulfilling promises of the Human Genome Project (2002)

Chiche, Jean-Daniel, Cariou, Alain, Mira, Jean-Paul

Abstract Since most common diseases have been shown to be influenced by inherited variations in our genes, completion of the Human Genome Project and mapping of the human genome single-nucleotide...

Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway

Mira, Jean-Paul, Benard, Valerie, Groffen, John, Sanders, Luraynne C., Knaus, Ulla G.

Uncontrolled cell proliferation is a major feature of cancer. Experimental cellular models have implicated some members of the Rho GTPase family in this process. However, direct evidence for active...

Bench-to-bedside review: Fulfilling promises of the Human Genome Project

Chiche, Jean-Daniel, Cariou, Alain, Mira, Jean-Paul

Since most common diseases have been shown to be influenced by inherited variations in our genes, completion of the Human Genome Project and mapping of the human genome single-nucleotide...

Bench-to-bedside review: Severe lactic acidosis in HIV patients treated with nucleoside analogue reverse transcriptase inhibitors

Claessens, Yann-Erick, Chiche, Jean-Daniel, Mira, Jean-Paul, Cariou, Alain

Nucleoside reverse transcriptase inhibitors (NRTIs) are effective antiretroviral therapy for the treatment of HIV-infected patients. NRTIs can induce mitochondrial impairment that leads to a number...

High levels of catalytic antibodies correlate with favorable outcome in sepsis

Lacroix-Desmazes, Sébastien, Bayry, Jagadeesh, Kaveri, Srini V., Hayon-Sonsino, David, Thorenoor, Nithyananda, Charpentier, Julien, ...

Sepsis is the leading cause of death in intensive care units and results from a deleterious systemic host response to infection. Although initially perceived as potentially deleterious, catalytic...

Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway

Mira, Jean-Paul, Benard, Valerie, Groffen, John, Sanders, Luraynne C., Knaus, Ulla G.

Uncontrolled cell proliferation is a major feature of cancer. Experimental cellular models have implicated some members of the Rho GTPase family in this process. However, direct evidence for active...

Bench-to-bedside review: Fulfilling promises of the Human Genome Project

Chiche, Jean-Daniel, Cariou, Alain, Mira, Jean-Paul

Since most common diseases have been shown to be influenced by inherited variations in our genes, completion of the Human Genome Project and mapping of the human genome single-nucleotide...

Bench-to-bedside review: Severe lactic acidosis in HIV patients treated with nucleoside analogue reverse transcriptase inhibitors

Claessens, Yann-Erick, Chiche, Jean-Daniel, Mira, Jean-Paul, Cariou, Alain

Nucleoside reverse transcriptase inhibitors (NRTIs) are effective antiretroviral therapy for the treatment of HIV-infected patients. NRTIs can induce mitochondrial impairment that leads to a number...

High levels of catalytic antibodies correlate with favorable outcome in sepsis

Lacroix-Desmazes, Sébastien, Bayry, Jagadeesh, Kaveri, Srini V., Hayon-Sonsino, David, Thorenoor, Nithyananda, Charpentier, Julien, ...

Sepsis is the leading cause of death in intensive care units and results from a deleterious systemic host response to infection. Although initially perceived as potentially deleterious, catalytic...