Understanding cardiac output (2008)
Abstract Cardiac output is the amount of blood the heart pumps in 1 minute, and it is dependent on the heart rate, contractility, preload, and afterload. Understanding of the applicability and...
Surviving sepsis: a guide to the guidelines (2008)
Vincent, Jean-Louis, Marshall, John C
Abstract The revised Surviving Sepsis Campaign (SSC) guidelines for the management of severe sepsis and septic shock have recently been published. These guidelines represent the end product of an...
Steroids in sepsis: another swing of the pendulum in our clinical trials (2008)
Abstract Many studies have been conducted to try and find interventions to treat patients with severe sepsis, but with little success. In several cases, initial apparent beneficial effects have not...
Correction: Management of bleeding following major trauma: a European guideline (2007)
Spahn, Donat R, Cerny, Vladimir, Coats, Timothy J, Duranteau, Jacques, Fernández-Mondéjar, Enrique, Gordini, Giovanni, ...
No abstract available.
Management of bleeding following major trauma: a European guideline (2007)
Spahn, Donat R, Cerny, Vladimir, Coats, Timothy J, Duranteau, Jacques, Fernández-Mondéjar, Enrique, Gordini, Giovanni, ...
Abstract Introduction Evidence-based recommendations can be made with respect to many aspects of the acute management of the bleeding trauma patient, which when implemented may lead to improved...
A reappraisal for the use of pulmonary artery catheters (2006)
No abstract available.
Vincent, Jean-Louis, Rossaint, Rolf, Riou, Bruno, Ozier, Yves, Zideman, David, Spahn, Donat R
Abstract Introduction Our aim was to develop consensus guidelines for use of recombinant activated factor VII (rFVIIa) in massive hemorrhage. Methods A guidelines committee derived the...
Heenen, Sarah, De Backer, Daniel, Vincent, Jean-Louis
Abstract Introduction The aim of the study was to evaluate the ability of different static and dynamic measurements of preload to predict fluid responsiveness in patients with spontaneous respiratory...
Vincent, Jean-Louis, O'Brien, James, Wheeler, Arthur, Wittebole, Xavier, Garg, Rekha, Trzaskoma, Benjamin L, ...
Abstract Introduction Several studies have indicated that early identification and treatment of patients with severe sepsis using standard supportive care improves outcomes. Earlier treatment with...
Elliott, D, McKinley, S, Alison, J A, Aitken, Leanne Maree, King, M T, Jean-Louis Vincent
Page numbers are not for citation purposes. Instead, this article has the unique article number of R90.
The Surviving Sepsis Campaign sepsis change bundles and clinical practice (2005)
Dellinger, R Phillip, Vincent, Jean-Louis
Abstract The Surviving Sepsis Campaign (SSC) is an international effort to reduce mortality in severe sepsis and septic shock. The campaign included the creation of evidence-based guidelines...
Vincent, Jean-Louis, Sakr, Yasser, Reinhart, Konrad, Sprung, Charles L, Gerlach, Herwig, Ranieri, V Marco, ...
Abstract Introduction Albumin administration in the critically ill has been the subject of some controversy. We investigated the use of albumin solutions in European intensive care units (ICUs) and...
Microvascular dysfunction as a cause of organ dysfunction in severe sepsis (2005)
Vincent, Jean-Louis, De Backer, Daniel
Abstract Reduced microvascular perfusion has been implicated in organ dysfunction and multiple organ failure associated with severe sepsis. The precise mechanisms underlying microvascular dysfunction...
Vincent, Jean-Louis, Nadel, Simon, Kutsogiannis, Demetrios J, Gibney, RT Noel, Yan, S Betty, Wyss, Virginia L, ...
Abstract Introduction We report data from adult and pediatric patients with severe sepsis from studies evaluating drotrecogin alfa (activated) (DrotAA) and presenting with purpura fulminans (PF),...
Withdrawing may be preferable to withholding (2005)
Abstract The majority of deaths on the intensive care unit now occur following a decision to limit life-sustaining therapy, and end-of-life decision making is an accepted and important part of modern...
Vincent, Jean-Louis, Brun-Buisson, Christian, Niederman, Michael, Haenni, Christian, Harbarth, Stephan, Sprumont, Dominique, ...
Abstract An elderly patient dies from septic shock in the intensive care unit. This is perhaps not an unusual scenario, but in this case the sepsis happens to have been due to methicillin-resistant...
Critical care in the 21st century: preparation, preparation, and preparation (2004)
England, Charlotte, Lapworth, Kerrie, Rahman, Emdadur, Vincent, Jean-Louis
No abstract available.
Evidence-based medicine journal club (2004)
Milbrandt, Eric B, Vincent, Jean-Louis
No abstract available.
Zouaoui Boudjeltia, Karim, Piagnerelli, Michael, Brohée, Dany, Guillaume, Michel, Cauchie, Philippe, Vincent, Jean-Louis, ...
Abstract Background- Endothelial cell dysfunction may be implicated in the development of multiple organ failure (MOF) by a number of mechanisms. Among these, altered fibrinolysis promotes fibrin...
Ethics roundtable debate: Child with severe brain damage and an underlying brain tumour (2004)
Gunn, Scott, Hashimoto, Satoru, Karakozov, Michael, Marx, Thomas, Tan, Ian KS, Thompson, Dan R, ...
Abstract A young person presents with a highly malignant brain tumour with hemiparesis and limited prognosis after resection. She then suffers an iatrogenic cardiac and respiratory arrest that...
Role of iron in anaemic critically ill patients: it's time to investigate! (2004)
Piagnerelli, Michael, Vincent, Jean-Louis
Abstract Anaemia is a common problem in critically ill patients admitted to intensive care units. Many factors can be involved in its development, including rapid alterations of iron metabolism....
Preiser, Jean-Charles, Peres-Bota, Daliana, Eisendrath, Pierre, Vincent, Jean-Louis, Van Gossum, André
Abstract Background Addition of glutamine to enteral nutrition formulas is consistently associated with a significant decrease in septic morbidity in critically ill patients, possibly related to the...
Critical Care's move to fund open access (2003)
Slade, Elizabeth, Tamber, Pritpal S, Vincent, Jean-Louis
No abstract available.
Abstract Despite a usually normal or high cardiac output, severe sepsis is associated with inadequate tissue oxygenation, leading to organ failure and death. Some authors have suggested that raising...
The PIRO concept: P is for predisposition (2003)
Angus, Derek C, Burgner, David, Wunderink, Richard, Mira, Jean-Paul, Gerlach, Herwig, Wiedermann, Christian J, ...
No abstract available.
The PIRO concept: I is for infection (2003)
Vincent, Jean-Louis, Opal, Steven, Torres, Antonio, Bonten, Marc, Cohen, Jonathan, Wunderink, Richard
No abstract available.
The PIRO Concept: O is for organ dysfunction (2003)
Vincent, Jean-Louis, Wendon, Julia, Groeneveld, Johan, Marshall, John C, Streat, Stephen, Carlet, Jean
No abstract available.
Critical Care: a good scientific citizen just got better (2003)
Tamber, Pritpal S, Slade, Elizabeth, Vincent, Jean-Louis
No abstract available.
Perioperative optimization and right heart catheterization: what technique in which patient? (2003)
De Backer, Daniel, Creteur, Jacques, Vincent, Jean-Louis
Abstract Recent years have seen the place of the pulmonary artery catheter in intensive care increasingly challenged, with one recent study reporting no difference in outcome in patients treated with...
Bernard, Gordon R, Macias, William L, Joyce, David E, Williams, Mark D, Bailey, Joan, Vincent, Jean-Louis
Abstract Introduction Drotrecogin alfa (activated; recombinant activated protein C) was shown to reduce 28-day all-cause mortality in patients with severe sepsis and to have an acceptable safety...
The Surviving Sepsis Campaign: raising awareness to reduce mortality (2003)
Slade, Elizabeth, Tamber, Pritpal S, Vincent, Jean-Louis
Abstract Sepsis affects 18 million people worldwide every year, and on average each case costs more than US$22 000 to treat. Despite this there is no consensus on the clinical definition of sepsis,...
Vincent, Jean-Louis, De Backer, Daniel
Abstract Norepinephrine (noradrenaline) and dopamine are commonly used first-line vasopressor agents in the treatment of patients with septic shock. Recently increasing interest has focused on...
Reducing mortality in sepsis: new directions (2002)
Vincent, Jean-Louis, Abraham, Edward, Annane, Djillali, Bernard, Gordon, Rivers, Emanuel, Van Den Berghe, Greet
Abstract Considerable progress has been made in the past few years in the development of therapeutic interventions that can reduce mortality in sepsis. However, encouraging physicians to put the...
The World Trade Center Attack: Lessons for all aspects of health care (2001)
Tamber, Pritpal S, Vincent, Jean-Louis
Abstract The attack on the World Trade Center had the potential to overwhelm New York's health services. Sadly, however, the predicted thousands of treatable patients failed to materialize. Horror...
Microvascular endothelial dysfunction: a renewed appreciation of sepsis pathophysiology (2001)
Abstract Severe sepsis, defined as sepsis associated with acute organ dysfunction, results from a generalized inflammatory and procoagulant host response to infection. Coagulopathy in severe sepsis...
Issues in contemporary fluid management (2000)
Abstract Fluid management strategies need to be guided by an understanding of the pathophysiologic mechanisms underlying fluid imbalance. In the hypovolaemic patient, reduced circulating blood volume...
Fluid management: the pharmacoeconomic dimension (2000)
Abstract Cost is a key concern in fluid management. Relatively few data are available that address the comparative total costs of care between different fluid management regimens in particular...
The World Trade Center Attack: Lessons for all aspects of health care
Tamber, Pritpal S, Vincent, Jean-Louis
The attack on the World Trade Center had the potential to overwhelm New York's health services. Sadly, however, the predicted thousands of treatable patients failed to materialize. Horror and sadness...
Vincent, Jean-Louis, De Backer, Daniel
Norepinephrine (noradrenaline) and dopamine are commonly used first-line vasopressor agents in the treatment of patients with septic shock. Recently increasing interest has focused on whether one or...
The Surviving Sepsis Campaign: raising awareness to reduce mortality
Slade, Elizabeth, Tamber, Pritpal S, Vincent, Jean-Louis
Sepsis affects 18 million people worldwide every year, and on average each case costs more than US$22 000 to treat. Despite this there is no consensus on the clinical definition of sepsis, and...
Preiser, Jean-Charles, Peres-Bota, Daliana, Eisendrath, Pierre, Vincent, Jean-Louis, Van Gossum, André
Bernard, Gordon R, Macias, William L, Joyce, David E, Williams, Mark D, Bailey, Joan, Vincent, Jean-Louis
Perioperative optimization and right heart catheterization: what technique in which patient?
De Backer, Daniel, Creteur, Jacques, Vincent, Jean-Louis
Recent years have seen the place of the pulmonary artery catheter in intensive care increasingly challenged, with one recent study reporting no difference in outcome in patients treated with or...
The PIRO concept: P is for predisposition
Angus, Derek C, Burgner, David, Wunderink, Richard, Mira, Jean-Paul, Gerlach, Herwig, Wiedermann, Christian J, ...
The PIRO concept: I is for infection
Vincent, Jean-Louis, Opal, Steven, Torres, Antonio, Bonten, Marc, Cohen, Jonathan, Wunderink, Richard
The PIRO Concept: O is for organ dysfunction
Vincent, Jean-Louis, Wendon, Julia, Groeneveld, Johan, Marshall, John C, Streat, Stephen, Carlet, Jean
Despite a usually normal or high cardiac output, severe sepsis is associated with inadequate tissue oxygenation, leading to organ failure and death. Some authors have suggested that raising cardiac...
Ethics roundtable debate: Child with severe brain damage and an underlying brain tumour
Gunn, Scott, Hashimoto, Satoru, Karakozov, Michael, Marx, Thomas, Tan, Ian KS, Thompson, Dan R, ...
A young person presents with a highly malignant brain tumour with hemiparesis and limited prognosis after resection. She then suffers an iatrogenic cardiac and respiratory arrest that results in...
Zouaoui Boudjeltia, Karim, Piagnerelli, Michael, Brohée, Dany, Guillaume, Michel, Cauchie, Philippe, Vincent, Jean-Louis, ...
Role of iron in anaemic critically ill patients: it's time to investigate!
Piagnerelli, Michael, Vincent, Jean-Louis
Anaemia is a common problem in critically ill patients admitted to intensive care units. Many factors can be involved in its development, including rapid alterations of iron metabolism. Maintenance...
Critical care in the 21st century: preparation, preparation, and preparation
England, Charlotte, Lapworth, Kerrie, Rahman, Emdadur, Vincent, Jean-Louis
Vincent, Jean-Louis, Brun-Buisson, Christian, Niederman, Michael, Haenni, Christian, Harbarth, Stephan, Sprumont, Dominique, ...
An elderly patient dies from septic shock in the intensive care unit. This is perhaps not an unusual scenario, but in this case the sepsis happens to have been due to methicillin-resistant...
Withdrawing may be preferable to withholding
The majority of deaths on the intensive care unit now occur following a decision to limit life-sustaining therapy, and end-of-life decision making is an accepted and important part of modern...
Vincent, Jean-Louis, Nadel, Simon, Kutsogiannis, Demetrios J, Gibney, RT Noel, Yan, S Betty, Wyss, Virginia L, ...
The Surviving Sepsis Campaign sepsis change bundles and clinical practice
Dellinger, R Phillip, Vincent, Jean-Louis
The Surviving Sepsis Campaign (SSC) is an international effort to reduce mortality in severe sepsis and septic shock. The campaign included the creation of evidence-based guidelines sponsored and...
Vincent, Jean-Louis, Sakr, Yasser, Reinhart, Konrad, Sprung, Charles L, Gerlach, Herwig, Ranieri, V Marco
Vincent, Jean-Louis, O'Brien, James, Wheeler, Arthur, Wittebole, Xavier, Garg, Rekha, Trzaskoma, Benjamin L, ...
Is the Current Management of Severe Sepsis and Septic Shock Really Evidence Based?
Vincent discusses the reasons why evidence-based medicine may be particularly difficult to apply in the management of patients with severe sepsis.
The World Trade Center Attack: Lessons for all aspects of health care
Tamber, Pritpal S, Vincent, Jean-Louis
The attack on the World Trade Center had the potential to overwhelm New York's health services. Sadly, however, the predicted thousands of treatable patients failed to materialize. Horror and sadness...
Vincent, Jean-Louis, De Backer, Daniel
Norepinephrine (noradrenaline) and dopamine are commonly used first-line vasopressor agents in the treatment of patients with septic shock. Recently increasing interest has focused on whether one or...
The Surviving Sepsis Campaign: raising awareness to reduce mortality
Slade, Elizabeth, Tamber, Pritpal S, Vincent, Jean-Louis
Sepsis affects 18 million people worldwide every year, and on average each case costs more than US$22 000 to treat. Despite this there is no consensus on the clinical definition of sepsis, and...
Preiser, Jean-Charles, Peres-Bota, Daliana, Eisendrath, Pierre, Vincent, Jean-Louis, Van Gossum, André
Bernard, Gordon R, Macias, William L, Joyce, David E, Williams, Mark D, Bailey, Joan, Vincent, Jean-Louis
Perioperative optimization and right heart catheterization: what technique in which patient?
De Backer, Daniel, Creteur, Jacques, Vincent, Jean-Louis
Recent years have seen the place of the pulmonary artery catheter in intensive care increasingly challenged, with one recent study reporting no difference in outcome in patients treated with or...
The PIRO concept: P is for predisposition
Angus, Derek C, Burgner, David, Wunderink, Richard, Mira, Jean-Paul, Gerlach, Herwig, Wiedermann, Christian J, ...
The PIRO concept: I is for infection
Vincent, Jean-Louis, Opal, Steven, Torres, Antonio, Bonten, Marc, Cohen, Jonathan, Wunderink, Richard
The PIRO Concept: O is for organ dysfunction
Vincent, Jean-Louis, Wendon, Julia, Groeneveld, Johan, Marshall, John C, Streat, Stephen, Carlet, Jean