Lemay, Julie, Maidou-Peindara, Priscilla, Bader, Thomas, Ennifar, Eric, Rain, Jean-Christophe, Benarous, Richard, ...
Abstract Reverse transcription of the genetic material of human immunodeficiency virus type 1 (HIV-1) is a critical step in the replication cycle of this virus. This process, catalyzed by reverse...
Functional Conservation of the Transportin Nuclear Import Pathway in Divergent Organisms
Siomi, Mikiko C., Fromont, Micheline, Rain, Jean-Christophe, Wan, Lili, Wang, Fan, Legrain, Pierre, ...
Human transportin1 (hTRN1) is the nuclear import receptor for a group of pre-mRNA/mRNA-binding proteins (heterogeneous nuclear ribonucleoproteins [hnRNP]) represented by hnRNP A1, which shuttle...
Antiviral Drug Discovery Strategy Using Combinatorial Libraries of Structurally Constrained Peptides
Real, Eléonore, Rain, Jean-Christophe, Battaglia, Véronique, Jallet, Corinne, Perrin, Pierre, Tordo, Noël, ...
We have developed a new strategy for antiviral peptide discovery by using lyssaviruses (rabies virus and rabies-related viruses) as models. Based on the mimicry of natural bioactive peptides, two...
The Splicing ATPase Prp43p Is a Component of Multiple Preribosomal Particles
Lebaron, Simon, Froment, Carine, Fromont-Racine, Micheline, Rain, Jean-Christophe, Monsarrat, Bernard, Caizergues-Ferrer, Michèle, ...
Prp43p is a putative helicase of the DEAH family which is required for the release of the lariat intron from the spliceosome. Prp43p could also play a role in ribosome synthesis, since it accumulates...
Functional Conservation of the Transportin Nuclear Import Pathway in Divergent Organisms
Siomi, Mikiko C., Fromont, Micheline, Rain, Jean-Christophe, Wan, Lili, Wang, Fan, Legrain, Pierre, ...
Human transportin1 (hTRN1) is the nuclear import receptor for a group of pre-mRNA/mRNA-binding proteins (heterogeneous nuclear ribonucleoproteins [hnRNP]) represented by hnRNP A1, which shuttle...
Antiviral Drug Discovery Strategy Using Combinatorial Libraries of Structurally Constrained Peptides
Real, Eléonore, Rain, Jean-Christophe, Battaglia, Véronique, Jallet, Corinne, Perrin, Pierre, Tordo, Noël, ...
We have developed a new strategy for antiviral peptide discovery by using lyssaviruses (rabies virus and rabies-related viruses) as models. Based on the mimicry of natural bioactive peptides, two...
The Splicing ATPase Prp43p Is a Component of Multiple Preribosomal Particles
Lebaron, Simon, Froment, Carine, Fromont-Racine, Micheline, Rain, Jean-Christophe, Monsarrat, Bernard, Caizergues-Ferrer, Michèle, ...
Prp43p is a putative helicase of the DEAH family which is required for the release of the lariat intron from the spliceosome. Prp43p could also play a role in ribosome synthesis, since it accumulates...
A functional network involved in the recycling of nucleocytoplasmic pre-60S factors
Lebreton, Alice, Saveanu, Cosmin, Decourty, Laurence, Rain, Jean-Christophe, Jacquier, Alain, Fromont-Racine, Micheline
Eukaryotic pre-ribosomes go through cytoplasmic maturation steps before entering translation. The nucleocytoplasmic proteins participating in these late stages of maturation are reimported to the...
Mousnier, Aurélie, Kubat, Nicole, Massias-Simon, Aurélie, Ségéral, Emmanuel, Rain, Jean-Christophe, Benarous, Richard, ...
HIV-1 integrase, the viral enzyme responsible for provirus integration into the host genome, can be actively degraded by the ubiquitin–proteasome pathway. Here, we identify von Hippel–Lindau...
Functional and physical interaction between Bcl-XL and a BH3-like domain in Beclin-1
Maiuri, M Chiara, Le Toumelin, Gaëtane, Criollo, Alfredo, Rain, Jean-Christophe, Gautier, Fabien, Juin, Philippe, ...
The anti-apoptotic proteins Bcl-2 and Bcl-XL bind and inhibit Beclin-1, an essential mediator of autophagy. Here, we demonstrate that this interaction involves a BH3 domain within Beclin-1 (residues...
Lemay, Julie, Maidou-Peindara, Priscilla, Bader, Thomas, Ennifar, Eric, Rain, Jean-Christophe, Benarous, Richard, ...
Reverse transcription of the genetic material of human immunodeficiency virus type 1 (HIV-1) is a critical step in the replication cycle of this virus. This process, catalyzed by reverse...
Genome-Wide Protein Interaction Screens Reveal Functional Networks Involving Sm-Like Proteins
Fromont-Racine, Micheline, Mayes, Andrew E., Brunet-Simon, Adeline, Rain, Jean-Christophe, Colley, Alan, Dix, Ian, ...
A set of seven structurally related Sm proteins forms the core of the snRNP particles containing the spliceosomal U1, U2, U4 and U5 snRNAs. A search of the genomic sequence of Saccharomyces...