Jean-Charles Schwartz

An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients. (2008)

Lin, Jian Sheng, Dauvilliers, Yves, Arnulf, Isabelle, Bastuji, Hélène, Anaclet, Christelle, Parmentier, Régis, ...

Narcolepsy is characterized by excessive daytime sleepiness (EDS), cataplexy, direct onsets of rapid eye movement (REM) sleep from wakefulness (DREMs) and deficiency of orexins, neuropeptides that...

An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients. (2008)

Lin, Jian Sheng, Dauvilliers, Yves, Arnulf, Isabelle, Bastuji, Hélène, Anaclet, Christelle, Parmentier, Régis, ...

Narcolepsy is characterized by excessive daytime sleepiness (EDS), cataplexy, direct onsets of rapid eye movement (REM) sleep from wakefulness (DREMs) and deficiency of orexins, neuropeptides that...

Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649. (2007)

Ligneau, Xavier, Landais, Laurent, Perrin, David, Piriou, Johanne, Uguen, Marilyne, Denis, Emmanuel, ...

BF2.649, a high affinity and selective non-imidazole histamine H(3)-receptor antagonist/inverse agonist, was found to easily enter the brain after oral administration to mice: it displayed a ratio of...

Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649. (2007)

Ligneau, Xavier, Landais, Laurent, Perrin, David, Piriou, Johanne, Uguen, Marilyne, Denis, Emmanuel, ...

BF2.649, a high affinity and selective non-imidazole histamine H(3)-receptor antagonist/inverse agonist, was found to easily enter the brain after oral administration to mice: it displayed a ratio of...

Induction of dopamine D3 receptor expression as a mechanism of behavioral sensitization to levodopa

Bordet, Régis, Ridray, Sophie, Carboni, Suzanna, Diaz, Jorge, Sokoloff, Pierre, Schwartz, Jean-Charles

In rats with unilateral lesions of the nigrostriatal dopamine pathway with 6-hydroxydopamine, the motor stimulating effects of levodopa, an indirect dopamine receptor agonist, evidenced by...

Protean agonism at histamine H3 receptors in vitro and in vivo

Gbahou, Florence, Rouleau, Agnès, Morisset, Séverine, Parmentier, Régis, Crochet, Sylvain, Lin, Jian-Sheng, ...

G protein-coupled receptors (GPCRs) are allosteric proteins that adopt inactive (R) and active (R*) conformations in equilibrium. R* is promoted by agonists or occurs spontaneously, leading to...

Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin.

Rose, Christiane, Voisin, Stéphanie, Gros, Claude, Schwartz, Jean-Charles, Ouimet, Tanja

Neprilysin (NEP) 2 is a recently cloned glycoprotein displaying a high degree of sequence identity with neprilysin (EC 3.4.24.11), the prototypical member of the M13 subfamily of metalloproteases....

Linkage analysis of schizophrenia with five dopamine receptor genes in nine pedigrees

Coon, Hilary, Byerley, William, Holik, John, Hoff, Mark, Myles-Worsley, Marina, Lannfelt, Lars, ...

Alterations in dopamine neurotransmission have been strongly implicated in the pathogenesis of schizophrenia for nearly 2 decades. Recently, the genes for five dopamine receptors have been cloned and...

Induction of dopamine D3 receptor expression as a mechanism of behavioral sensitization to levodopa

Bordet, Régis, Ridray, Sophie, Carboni, Suzanna, Diaz, Jorge, Sokoloff, Pierre, Schwartz, Jean-Charles

In rats with unilateral lesions of the nigrostriatal dopamine pathway with 6-hydroxydopamine, the motor stimulating effects of levodopa, an indirect dopamine receptor agonist, evidenced by...

Protean agonism at histamine H3 receptors in vitro and in vivo

Gbahou, Florence, Rouleau, Agnès, Morisset, Séverine, Parmentier, Régis, Crochet, Sylvain, Lin, Jian-Sheng, ...

G protein-coupled receptors (GPCRs) are allosteric proteins that adopt inactive (R) and active (R*) conformations in equilibrium. R* is promoted by agonists or occurs spontaneously, leading to...

Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin.

Rose, Christiane, Voisin, Stéphanie, Gros, Claude, Schwartz, Jean-Charles, Ouimet, Tanja

Neprilysin (NEP) 2 is a recently cloned glycoprotein displaying a high degree of sequence identity with neprilysin (EC 3.4.24.11), the prototypical member of the M13 subfamily of metalloproteases....

Linkage analysis of schizophrenia with five dopamine receptor genes in nine pedigrees

Coon, Hilary, Byerley, William, Holik, John, Hoff, Mark, Myles-Worsley, Marina, Lannfelt, Lars, ...

Alterations in dopamine neurotransmission have been strongly implicated in the pathogenesis of schizophrenia for nearly 2 decades. Recently, the genes for five dopamine receptors have been cloned and...