A Role for Perforin in Downregulating T-Cell Responses during Chronic Viral Infection
Matloubian, Mehrdad, Suresh, M., Glass, Alison, Galvan, Marisa, Chow, Kit, Whitmire, Jason K., ...
Cytotoxic T cells secrete perforin to kill virus-infected cells. In this study we show that perforin also plays a role in immune regulation. Perforin-deficient (perf −/−) mice chronically...
Long-Term CD4 Th1 and Th2 Memory following Acute Lymphocytic Choriomeningitis Virus Infection
Whitmire, Jason K., Asano, Mary S., Murali-Krishna, Kaja, Suresh, M., Ahmed, Rafi
CD4 T cells play a central role in viral immunity. They provide help for B cells and CD8 T cells and can act as effectors themselves. Despite their importance, relatively little is known about the...
Role of Lymphotoxin α in T-Cell Responses during an Acute Viral Infection
Suresh, M., Lanier, Gibson, Large, Mary Katherine, Whitmire, Jason K., Altman, John D., Ruddle, Nancy H., ...
The importance of lymphotoxin α (LTα) in lymphoid organogenesis is well established. Although LTα has been implicated in the pathogenesis of T-cell-mediated immunopathologies, the requirement for...
CD4 on CD8+ T cells directly enhances effector function and is a target for HIV infection
Kitchen, Scott G., Jones, Nicole R., LaForge, Stuart, Whitmire, Jason K., Vu, Bien-Aimee, Galic, Zoran, ...
Costimulation of purified CD8+ T lymphocytes induces de novo expression of CD4, suggesting a previously unrecognized function for this molecule in the immune response. Here, we report that the CD4...
Kitchen, Scott G., Whitmire, Jason K., Jones, Nicole R., Galic, Zoran, Kitchen, Christina M. R., Ahmed, Rafi, ...
CD8+ T lymphocytes play a major role in cellular-mediated immune responses to foreign antigen. We have previously demonstrated that costimulation of purified human CD8+ T cells induces de novo...
A Role for Perforin in Downregulating T-Cell Responses during Chronic Viral Infection
Matloubian, Mehrdad, Suresh, M., Glass, Alison, Galvan, Marisa, Chow, Kit, Whitmire, Jason K., ...
Cytotoxic T cells secrete perforin to kill virus-infected cells. In this study we show that perforin also plays a role in immune regulation. Perforin-deficient (perf −/−) mice chronically...
Long-Term CD4 Th1 and Th2 Memory following Acute Lymphocytic Choriomeningitis Virus Infection
Whitmire, Jason K., Asano, Mary S., Murali-Krishna, Kaja, Suresh, M., Ahmed, Rafi
CD4 T cells play a central role in viral immunity. They provide help for B cells and CD8 T cells and can act as effectors themselves. Despite their importance, relatively little is known about the...
Role of Lymphotoxin α in T-Cell Responses during an Acute Viral Infection
Suresh, M., Lanier, Gibson, Large, Mary Katherine, Whitmire, Jason K., Altman, John D., Ruddle, Nancy H., ...
The importance of lymphotoxin α (LTα) in lymphoid organogenesis is well established. Although LTα has been implicated in the pathogenesis of T-cell-mediated immunopathologies, the requirement for...
CD4 on CD8+ T cells directly enhances effector function and is a target for HIV infection
Kitchen, Scott G., Jones, Nicole R., LaForge, Stuart, Whitmire, Jason K., Vu, Bien-Aimee, Galic, Zoran, ...
Costimulation of purified CD8+ T lymphocytes induces de novo expression of CD4, suggesting a previously unrecognized function for this molecule in the immune response. Here, we report that the CD4...
Kitchen, Scott G., Whitmire, Jason K., Jones, Nicole R., Galic, Zoran, Kitchen, Christina M. R., Ahmed, Rafi, ...
CD8+ T lymphocytes play a major role in cellular-mediated immune responses to foreign antigen. We have previously demonstrated that costimulation of purified human CD8+ T cells induces de novo...
Crocker, Stephen J., Whitmire, Jason K., Frausto, Ricardo F., Chertboonmuang, Parntip, Soloway, Paul D., Whitton, J. Lindsay, ...
Increased leukocyte trafficking into the parenchyma during inflammatory responses in the central nervous system (CNS) is facilitated by the extracellular proteolytic activities of matrix...
HLA-A2-Restricted Protection against Lethal Lymphocytic Choriomeningitis▿ †
Botten, Jason, Whitton, J. Lindsay, Barrowman, Polly, Sidney, John, Whitmire, Jason K., Alexander, Jeff, ...
The consequences of human lymphocytic choriomeningitis virus (LCMV) infection can be severe, including aseptic meningitis in immunocompetent individuals, hydrocephalus or chorioretinitis in fetal...
Interferon-γ acts directly on CD8+ T cells to increase their abundance during virus infection
Whitmire, Jason K., Tan, Joyce T., Whitton, J. Lindsay
Interferon-γ (IFNγ) is important in regulating the adaptive immune response, and most current evidence suggests that it exerts a negative (proapoptotic) effect on CD8+ T cell responses. We have...
Tentative T Cells: Memory Cells Are Quick to Respond, but Slow to Divide
Whitmire, Jason K., Eam, Boreth, Whitton, J. Lindsay
T cell memory is a cornerstone of protective immunity, and is the key element in successful vaccination. Upon encountering the relevant pathogen, memory T cells are thought to initiate cell division...
Crocker, Stephen J., Frausto, Ricardo F., Whitmire, Jason K., Benning, Nicola, Milner, Richard, Whitton, J. Lindsay
Coxsackievirus B3 (CVB3) is a major cause of acute myocarditis, a serious condition that is refractory to treatment. Myocardial damage results in tissue remodeling that, if too extensive, may...
Iannacone, Matteo, Sitia, Giovanni, Isogawa, Masanori, Whitmire, Jason K., Marchese, Patrizia, Chisari, Francis V., ...
We found that mice infected with different isolates of lymphocytic choriomeningitis virus (LCMV) develop a mild hemorrhagic anemia, which becomes severe and eventually lethal in animals depleted of...
Sourdive, David J.D., Murali-Krishna, Kaja, Altman, John D., Zajac, Allan J., Whitmire, Jason K., Pannetier, Christophe, ...
Viral infections often induce potent CD8 T cell responses that play a key role in antiviral immunity. After viral clearance, the vast majority of the expanded CD8 T cells undergo apoptosis, leaving...