Proliferation is necessary for both repair and mutation in transgenic mouse cells
Bielas, Jason H., Heddle, John A.
Proliferating cells are often presumed to be more mutable than quiescent cells because they have less time to repair DNA damage before DNA replication. Direct tests of this hypothesis have been...
Bielas, Jason H., Heddle, John A.
p53, the most commonly mutated gene in human tumors, is believed to play a crucial role in the prevention of cancer by protecting cells from mutation, a theory commonly known as the “Guardian of...
Proliferation is necessary for both repair and mutation in transgenic mouse cells
Bielas, Jason H., Heddle, John A.
Proliferating cells are often presumed to be more mutable than quiescent cells because they have less time to repair DNA damage before DNA replication. Direct tests of this hypothesis have been...
Bielas, Jason H., Heddle, John A.
p53, the most commonly mutated gene in human tumors, is believed to play a crucial role in the prevention of cancer by protecting cells from mutation, a theory commonly known as the “Guardian of...
Human cancers express a mutator phenotype
Bielas, Jason H., Loeb, Keith R., Rubin, Brian P., True, Lawrence D., Loeb, Lawrence A.
Cancer cells contain numerous clonal mutations, i.e., mutations that are present in most or all malignant cells of a tumor and have presumably been selected because they confer a proliferative...