Janet Kelso

Representing default knowledge in biomedical ontologies: application to the integration of anatomy and phenotype ontologies (2007)

Hoehndorf, Robert, Loebe, Frank, Kelso, Janet, Herre, Heinrich

Abstract Background Current efforts within the biomedical ontology community focus on achieving interoperability between various biomedical ontologies that cover a range of diverse domains. Achieving...

Functionality of Intergenic Transcription: An Evolutionary Comparison (2006)

Philipp Khaitovich, Janet Kelso, Henriette Franz, Johann Visagie, Thomas Giger, Sabrina Joerchel, ...

Although a large proportion of human transcription occurs outside the boundaries of known genes, the functional significance of this transcription remains unknown. We have compared the expression...

Functionality of Intergenic Transcription: An Evolutionary Comparison (2006)

Philipp Khaitovich, Janet Kelso, Henriette Franz, Johann Visagie, Thomas Giger, Sabrina Joerchel, ...

Although a large proportion of human transcription occurs outside the boundaries of known genes, the functional significance of this transcription remains unknown. We have compared the expression...

Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones (2004)

Tadashi Imanishi, Takeshi Itoh, Yutaka Suzuki, Claire O'Donovan, Satoshi Fukuchi, Kanako O. Koyanagi, ...

An international team has systematically validated and annotated just over 21,000 human genes using full-length cDNA, thereby providing a valuable new resource for the human genetics community.

Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones (2004)

Tadashi Imanishi, Takeshi Itoh, Yutaka Suzuki, Claire O'Donovan, Satoshi Fukuchi, Kanako O. Koyanagi, ...

The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...

Transcriptome Analysis of Mouse Stem Cells and Early Embryos (2003)

Alexei A. Sharov, Yulan Piao, Ryo Matoba, Dawood B. Dudekula, Yong Qian, Vincent VanBuren, ...

250,000 EST sequences from oocytes, blastocysts, and embryonic and adult stem cells contribute to the annotation of the mouse genome and suggest genes that contribute to the unique features of these...

Transcriptome Analysis of Mouse Stem Cells and Early Embryos (2003)

Alexei A. Sharov, Yulan Piao, Ryo Matoba, Dawood B. Dudekula, Yong Qian, Vincent VanBuren, ...

Understanding and harnessing cellular potency are fundamental in biology and are also critical to the future therapeutic use of stem cells. Transcriptome analysis of these pluripotent cells is a...

The development and application of informatics-based systems for the analysis of the human transcriptome. (2003)

Kelso, Janet

Despite the fact that the sequence of the human genome is now complete it has become clear that the elucidation of the transcriptome is more complicated than previously expected. There is mounting...

The development and application of informatics-based systems for the analysis of the human transcriptome. (2003)

Kelso, Janet

Despite the fact that the sequence of the human genome is now complete it has become clear that the elucidation of the transcriptome is more complicated than previously expected. There is mounting...

Impact of the Presence of Paralogs on Sequence Divergence in a Set of Mouse-Human Orthologs

Nembaware, Victoria, Crum, Karen, Kelso, Janet, Seoighe, Cathal

Using a large set of orthologous human and mouse gene pairs, we have characterized genes that have been retained in duplicate in human over timescales comparable to the time of speciation of human...

Assembly, Verification, and Initial Annotation of the NIA Mouse 7.4K cDNA Clone Set

VanBuren, Vincent, Piao, Yulan, Dudekula, Dawood B., Qian, Yong, Carter, Mark G., Martin, Patrick R., ...

A set of 7407 cDNA clones (NIA mouse 7.4K) was assembled from >20 cDNA libraries constructed mainly from early mouse embryos, including several stem cell libraries. The clone set was assembled from...

The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags

Brentani, Helena, Caballero, Otávia L., Camargo, Anamaria A., Da Silva, Aline M., Da Silva, Wilson Araújo, Neto, Emmanuel Dias, ...

Whereas genome sequencing defines the genetic potential of an organism, transcript sequencing defines the utilization of this potential and links the genome with most areas of biology. To exploit the...

Transcriptome Analysis of Mouse Stem Cells and Early Embryos

Sharov, Alexei A, Piao, Yulan, Matoba, Ryo, Dudekula, Dawood B, Qian, Yong, VanBuren, Vincent, ...

Understanding and harnessing cellular potency are fundamental in biology and are also critical to the future therapeutic use of stem cells. Transcriptome analysis of these pluripotent cells is a...

Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones

Imanishi, Tadashi, Itoh, Takeshi, Suzuki, Yutaka, O'Donovan, Claire, Fukuchi, Satoshi, Koyanagi, Kanako O, ...

The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...

eVOC: A Controlled Vocabulary for Unifying Gene Expression Data

Kelso, Janet, Visagie, Johann, Theiler, Gregory, Christoffels, Alan, Bardien, Soraya, Smedley, Damian, ...

Expression data contribute significantly to the biological value of the sequenced human genome,providing extensive information about gene structure and the pattern of gene expression. ESTs,together...

The Human Anatomic Gene Expression Library (H-ANGEL), the H-Inv integrative display of human gene expression across disparate technologies and platforms

Tanino, Motohiko, Debily, Marie-Anne, Tamura, Takuro, Hishiki, Teruyoshi, Ogasawara, Osamu, Murakawa, Katsuji, ...

The Human Anatomic Gene Expression Library (H-ANGEL) is a resource for information concerning the anatomical distribution and expression of human gene transcripts. The tool contains protein...

Functionality of Intergenic Transcription: An Evolutionary Comparison

Khaitovich, Philipp, Kelso, Janet, Franz, Henriette, Visagie, Johann, Giger, Thomas, Joerchel, Sabrina, ...

Although a large proportion of human transcription occurs outside the boundaries of known genes, the functional significance of this transcription remains unknown. We have compared the expression...

Impact of the Presence of Paralogs on Sequence Divergence in a Set of Mouse-Human Orthologs

Nembaware, Victoria, Crum, Karen, Kelso, Janet, Seoighe, Cathal

Using a large set of orthologous human and mouse gene pairs, we have characterized genes that have been retained in duplicate in human over timescales comparable to the time of speciation of human...

Assembly, Verification, and Initial Annotation of the NIA Mouse 7.4K cDNA Clone Set

VanBuren, Vincent, Piao, Yulan, Dudekula, Dawood B., Qian, Yong, Carter, Mark G., Martin, Patrick R., ...

A set of 7407 cDNA clones (NIA mouse 7.4K) was assembled from >20 cDNA libraries constructed mainly from early mouse embryos, including several stem cell libraries. The clone set was assembled from...

The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags

Brentani, Helena, Caballero, Otávia L., Camargo, Anamaria A., Da Silva, Aline M., Da Silva, Wilson Araújo, Neto, Emmanuel Dias, ...

Whereas genome sequencing defines the genetic potential of an organism, transcript sequencing defines the utilization of this potential and links the genome with most areas of biology. To exploit the...

Transcriptome Analysis of Mouse Stem Cells and Early Embryos

Sharov, Alexei A, Piao, Yulan, Matoba, Ryo, Dudekula, Dawood B, Qian, Yong, VanBuren, Vincent, ...

Understanding and harnessing cellular potency are fundamental in biology and are also critical to the future therapeutic use of stem cells. Transcriptome analysis of these pluripotent cells is a...

Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones

Imanishi, Tadashi, Itoh, Takeshi, Suzuki, Yutaka, O'Donovan, Claire, Fukuchi, Satoshi, Koyanagi, Kanako O, ...

The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...

eVOC: A Controlled Vocabulary for Unifying Gene Expression Data

Kelso, Janet, Visagie, Johann, Theiler, Gregory, Christoffels, Alan, Bardien, Soraya, Smedley, Damian, ...

Expression data contribute significantly to the biological value of the sequenced human genome,providing extensive information about gene structure and the pattern of gene expression. ESTs,together...

The Human Anatomic Gene Expression Library (H-ANGEL), the H-Inv integrative display of human gene expression across disparate technologies and platforms

Tanino, Motohiko, Debily, Marie-Anne, Tamura, Takuro, Hishiki, Teruyoshi, Ogasawara, Osamu, Murakawa, Katsuji, ...

The Human Anatomic Gene Expression Library (H-ANGEL) is a resource for information concerning the anatomical distribution and expression of human gene transcripts. The tool contains protein...

Functionality of Intergenic Transcription: An Evolutionary Comparison

Khaitovich, Philipp, Kelso, Janet, Franz, Henriette, Visagie, Johann, Giger, Thomas, Joerchel, Sabrina, ...

Although a large proportion of human transcription occurs outside the boundaries of known genes, the functional significance of this transcription remains unknown. We have compared the expression...

Comparison of Protein and mRNA Expression Evolution in Humans and Chimpanzees

Fu, Ning, Drinnenberg, Ines, Kelso, Janet, Wu, Jia-Rui, Pääbo, Svante, Zeng, Rong, ...

Even though mRNA expression levels are commonly used as a proxy for estimating functional differences that occur at the protein level, the relation between mRNA and protein expression is not well...

Patterns of damage in genomic DNA sequences from a Neandertal

Briggs, Adrian W., Stenzel, Udo, Johnson, Philip L. F., Green, Richard E., Kelso, Janet, Prüfer, Kay, ...

High-throughput direct sequencing techniques have recently opened the possibility to sequence genomes from Pleistocene organisms. Here we analyze DNA sequences determined from a Neandertal, a...