A targeted mutation in the IL-4Rα gene protects mice against autoimmune diabetes
Radu, Dorel L., Noben-Trauth, Nancy, Hu-Li, Jane, Paul, William E., Bona, Constantin A.
Autoimmune insulin-dependent diabetes mellitus (IDDM) occurs spontaneously in mice-bearing transgenes encoding the influenza hemagglutinin under the control of the rat insulin promoter and a T cell...
Hu-Li, Jane, Huang, Hua, Ryan, John, Paul, William E.
CD4+ T cells from T cell receptor transgenic mice that have been vigorously primed to be interleukin (IL)-4 producers (TH2 cells) are capable of producing IL-4 even if restimulated in the absence of...
T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6
Dent, Alexander L., Hu-Li, Jane, Paul, William E., Staudt, Louis M.
An important signaling pathway for the differentiation of T helper type 2 (TH2) cells from uncommitted CD4 T cell precursors is activation of the STAT6 transcription factor by interleukin 4 (IL-4)....
Guo, Liying, Hu-Li, Jane, Zhu, Jinfang, Watson, Cynthia J., Difilippantonio, Michael J., Pannetier, Christophe, ...
TH2 clones may produce very variable amounts of IL-4. Among six TH2 clones prepared from homozygous or heterozygous mice in which Gfp replaced the first exon of Il4, a range of patterns of CpG...
Löhning, Max, Richter, Anne, Stamm, Torsten, Hu-Li, Jane, Assenmacher, Mario, Paul, William E., ...
T helper (Th) lymphocytes can develop memory for the expression of particular cytokines, like IL-4 or IL-10, in that reexpression of those cytokines is independent of the original costimulatory...
Interleukin 2 plays a central role in Th2 differentiation
Cote-Sierra, Javier, Foucras, Gilles, Guo, Liying, Chiodetti, Lynda, Young, Howard A., Hu-Li, Jane, ...
Differentiation of naïve CD4 T cells into T helper (Th) 2 cells requires signaling through the T cell receptor and an appropriate cytokine environment. IL-4 is critical for such Th2 differentiation....
A targeted mutation in the IL-4Rα gene protects mice against autoimmune diabetes
Radu, Dorel L., Noben-Trauth, Nancy, Hu-Li, Jane, Paul, William E., Bona, Constantin A.
Autoimmune insulin-dependent diabetes mellitus (IDDM) occurs spontaneously in mice-bearing transgenes encoding the influenza hemagglutinin under the control of the rat insulin promoter and a T cell...
Hu-Li, Jane, Huang, Hua, Ryan, John, Paul, William E.
CD4+ T cells from T cell receptor transgenic mice that have been vigorously primed to be interleukin (IL)-4 producers (TH2 cells) are capable of producing IL-4 even if restimulated in the absence of...
T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6
Dent, Alexander L., Hu-Li, Jane, Paul, William E., Staudt, Louis M.
An important signaling pathway for the differentiation of T helper type 2 (TH2) cells from uncommitted CD4 T cell precursors is activation of the STAT6 transcription factor by interleukin 4 (IL-4)....
Guo, Liying, Hu-Li, Jane, Zhu, Jinfang, Watson, Cynthia J., Difilippantonio, Michael J., Pannetier, Christophe, ...
TH2 clones may produce very variable amounts of IL-4. Among six TH2 clones prepared from homozygous or heterozygous mice in which Gfp replaced the first exon of Il4, a range of patterns of CpG...
Löhning, Max, Richter, Anne, Stamm, Torsten, Hu-Li, Jane, Assenmacher, Mario, Paul, William E., ...
T helper (Th) lymphocytes can develop memory for the expression of particular cytokines, like IL-4 or IL-10, in that reexpression of those cytokines is independent of the original costimulatory...
Interleukin 2 plays a central role in Th2 differentiation
Cote-Sierra, Javier, Foucras, Gilles, Guo, Liying, Chiodetti, Lynda, Young, Howard A., Hu-Li, Jane, ...
Differentiation of naïve CD4 T cells into T helper (Th) 2 cells requires signaling through the T cell receptor and an appropriate cytokine environment. IL-4 is critical for such Th2 differentiation....
Basophils Produce IL-4 and Accumulate in Tissues after Infection with a Th2-inducing Parasite
Min, Booki, Prout, Melanie, Hu-Li, Jane, Zhu, Jinfang, Jankovic, Dragana, Morgan, Ellen S., ...
Using mice in which the eGfp gene replaced the first exon of the Il4 gene (G4 mice), we examined production of interleukin (IL)-4 during infection by the intestinal nematode Nippostrongylus...
Smeltz, Ronald B., Chen, June, Hu-Li, Jane, Shevach, Ethan M.
Interleukin (IL)-18 has been well characterized as a costimulatory factor for the induction of IL-12–mediated interferon (IFN)-γ production by T helper (Th)1 cells, but also can induce IL-4...
Interferon γ Stabilizes the T Helper Cell Type 1 Phenotype
Zhang, Yongkang, Apilado, Ron, Coleman, John, Ben-Sasson, Shlomo, Tsang, Sharon, Hu-Li, Jane, ...
T helper cell (Th)1-primed CD4 T cells from wild-type donors make little interleukin (IL)-4 when restimulated under Th2 conditions. However, such restimulation of Th1-primed cells from interferon...
Transient Inhibition of Interleukin 4 Signaling by T Cell Receptor Ligation
Zhu, Jinfang, Huang, Hua, Guo, Liying, Stonehouse, Timothy, Watson, Cynthia J., Hu-Li, Jane, ...
Interleukin (IL)-4 and IL-12 together with T cell receptor (TCR) engagement are crucial for the differentiation of CD4+ T cells into T helper (Th)2 or Th1 cells, respectively. Although IL-4 receptors...