Jan van der Greef

Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis (2007)

Kleemann, Robert, Verschuren, Lars, Van Erk, Marjan J, Nikolsky, Yuri, Cnubben, Nicole HP, Verheij, Elwin R, ...

Abstract Background Increased dietary cholesterol intake is associated with atherosclerosis. Atherosclerosis development requires a lipid and an inflammatory component. It is unclear where and how...

Statistical validation of megavariate effects in ASCA (2007)

Vis, Daniel J, Westerhuis, Johan A, Smilde, Age K, Van Der Greef, Jan

Abstract Background Innovative extensions of (M) ANOVA gain common ground for the analysis of designed metabolomics experiments. ASCA is such a multivariate analysis method; it has successfully...

Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis

Kleemann, Robert, Verschuren, Lars, Van Erk, Marjan J, Nikolsky, Yuri, Cnubben, Nicole HP, Verheij, Elwin R, ...

With increasing dietary cholesterol intake the liver switches from a mainly resilient to a predominantly inflammatory state, which is associated with early lesion formation.