Copy Number Variants and Segmental Duplications Show Different Formation Signatures (2007)
Kim, Philip M., Korbel, Jan O., Chen, Xueying, Gerstein, Mark B.
In addition to variation in terms of single nucleotide polymorphisms (SNPs), whole regions ranging from several kilobases up to a megabase in length differ in copy number among individuals. These...
Prediction of effective genome size in metagenomic samples (2007)
Raes, Jeroen, Korbel, Jan O, Lercher, Martin J, Von Mering, Christian, Bork, Peer
Abstract We introduce a novel computational approach to predict effective genome size (EGS; a measure that includes multiple plasmid copies, inserted sequences, and associated phages and viruses)...
Systematic Association of Genes to Phenotypes by Genome and Literature Mining (2005)
Jan O. Korbel, Tobias Doerks, Lars J. Jensen, Carolina Perez-Iratxeta, Szymon Kaczanowski, Sean D. Hooper, ...
The combination of text mining and comparative genomics is shown to be a powerful approach to predicting phenotypes that are associated with particular genes in bacterial genomes.
Systematic Association of Genes to Phenotypes by Genome and Literature Mining (2005)
Jan O. Korbel, Tobias Doerks, Lars J. Jensen, Carolina Perez-Iratxeta, Szymon Kaczanowski, Sean D. Hooper, ...
One of the major challenges of functional genomics is to unravel the connection between genotype and phenotype. So far no global analysis has attempted to explore those connections in the light of...
Systematic Association of Genes to Phenotypes by Genome and Literature Mining
Korbel, Jan O, Doerks, Tobias, Jensen, Lars J, Perez-Iratxeta, Carolina, Kaczanowski, Szymon, Hooper, Sean D, ...
One of the major challenges of functional genomics is to unravel the connection between genotype and phenotype. So far no global analysis has attempted to explore those connections in the light of...
Urban, Alexander Eckehart, Korbel, Jan O., Selzer, Rebecca, Richmond, Todd, Hacker, April, Popescu, George V., ...
Deletions and amplifications of the human genomic sequence (copy number polymorphisms) are the cause of numerous diseases and a potential cause of phenotypic variation in the normal population....
Systematic Association of Genes to Phenotypes by Genome and Literature Mining
Korbel, Jan O, Doerks, Tobias, Jensen, Lars J, Perez-Iratxeta, Carolina, Kaczanowski, Szymon, Hooper, Sean D, ...
One of the major challenges of functional genomics is to unravel the connection between genotype and phenotype. So far no global analysis has attempted to explore those connections in the light of...
Urban, Alexander Eckehart, Korbel, Jan O., Selzer, Rebecca, Richmond, Todd, Hacker, April, Popescu, George V., ...
Deletions and amplifications of the human genomic sequence (copy number polymorphisms) are the cause of numerous diseases and a potential cause of phenotypic variation in the normal population....
Prediction of effective genome size in metagenomic samples
Raes, Jeroen, Korbel, Jan O, Lercher, Martin J, Von Mering, Christian, Bork, Peer
A novel computational approach shows a link between genome size and habitat from analysis of environmental metagenomic DNA reads.
Rozowsky, Joel S., Newburger, Daniel, Sayward, Fred, Wu, Jiaqian, Jordan, Greg, Korbel, Jan O., ...
For the ∼1% of the human genome in the ENCODE regions, only about half of the transcriptionally active regions (TARs) identified with tiling microarrays correspond to annotated exons. Here we...
Structured RNAs in the ENCODE selected regions of the human genome
Washietl, Stefan, Pedersen, Jakob S., Korbel, Jan O., Stocsits, Claudia, Gruber, Andreas R., Hackermüller, Jörg, ...
Functional RNA structures play an important role both in the context of noncoding RNA transcripts as well as regulatory elements in mRNAs. Here we present a computational study to detect functional...
Korbel, Jan O., Urban, Alexander Eckehart, Grubert, Fabian, Du, Jiang, Royce, Thomas E., Starr, Peter, ...
Copy-number variants (CNVs) are an abundant form of genetic variation in humans. However, approaches for determining exact CNV breakpoint sequences (physical deletion or duplication boundaries)...
Kim, Philip M., Korbel, Jan O., Gerstein, Mark B.
Because of recent advances in genotyping and sequencing, human genetic variation and adaptive evolution in the primate lineage have become major research foci. Here, we examine the relationship...
High-Resolution Copy-Number Variation Map Reflects Human Olfactory Receptor Diversity and Evolution
Hasin, Yehudit, Olender, Tsviya, Khen, Miriam, Gonzaga-Jauregui, Claudia, Kim, Philip M., Urban, Alexander Eckehart, ...
Olfactory receptors (ORs), which are involved in odorant recognition, form the largest mammalian protein superfamily. The genomic content of OR genes is considerably reduced in humans, as reflected...