Cathepsin K Is the Principal Protease in Giant Cell Tumor of Bone
Lindeman, Jan H.N., Hanemaaijer, Roeland, Mulder, Adri, Dijkstra, P.D. Sander, Szuhai, Károly, Bromme, Dieter, ...
Giant cell tumor (GCT) of bone is a neoplasm of bone characterized by a localized osteolytic lesion. The nature of GCT is an enigma and the cell type(s) and protease(s) responsible for the extensive...
Abdul-Hussien, Hazem, Soekhoe, Ratna G.V., Weber, Ekkehard, Von Der Thüsen, Jan H., Kleemann, Robert, Mulder, Adri, ...
Growth and rupture of abdominal aortic aneurysms (AAAs) result from increased collagen turnover. Collagen turnover critically depends on specific collagenases that cleave the triple helical region of...