Husain, S. Mazher, Usherwood, Edward J., Dyson, Heather, Coleclough, Christopher, Coppola, Michael A., Woodland, David L., ...
Murine gammaherpesvirus 68 (MHV-68) infection of mice is a potential model with which to address fundamental aspects of the pathobiology and host control of gammaherpesvirus latency. Control of...
Rta of Murine Gammaherpesvirus 68 Reactivates the Complete Lytic Cycle from Latency
Wu, Ting-Ting, Usherwood, Edward J., Stewart, James P., Nash, Anthony A., Sun, Ren
Herpesviruses are characterized as having two distinct life cycle phases: lytic replication and latency. The mechanisms of latency establishment and maintenance, as well as the switch from latency to...
Macrae, Alastair I., Dutia, Bernadette M., Milligan, Steven, Brownstein, David G., Allen, Deborah J., Mistrikova, Jela, ...
Role of Tachykinins in the Host Response to Murine Gammaherpesvirus Infection
Payne, Catherine M., Heggie, Caroline J., Brownstein, David G., Stewart, James P., Quinn, John P.
Tachykinins function not only as neurotransmitters but also as immunological mediators. We used infection of tachykinin-deficient (PPT-A−/−) mice and wild-type controls with murine...
Macrae, Alastair I., Dutia, Bernadette M., Milligan, Steven, Brownstein, David G., Allen, Deborah J., Mistrikova, Jela, ...
Infection of mice by murine gammaherpesvirus 68 (MHV-68) is an excellent small-animal model of gammaherpesvirus pathogenesis in a natural host. We have carried out comparative studies of another...
Latent Antigen Vaccination in a Model Gammaherpesvirus Infection
Usherwood, Edward J., Ward, Kimberley A., Blackman, Marcia A., Stewart, James P., Woodland, David L.
Vaccines that can reduce the load of latent gammaherpesvirus infections are eagerly sought. One attractive strategy is vaccination against latency-associated proteins, which may increase the...
Macrae, Alastair I., Usherwood, Edward J., Husain, S. Mazher, Flaño, Emilio, Kim, In-Jeong, Woodland, David L., ...
This work describes analyses of the function of the murid herpesvirus 4 strain 68 (MHV-68) M2 gene. A frameshift mutation was made in the M2 open reading frame that caused premature termination of...
Identification of Proteins Associated with Murine Gammaherpesvirus 68 Virions
Bortz, Eric, Whitelegge, Julian P., Jia, Qingmei, Zhou, Z. Hong, Stewart, James P., Wu, Ting-Ting, ...
Murine gammaherpesvirus 68 (MHV68 [also known as γHV-68]) is distinguished by its ability to replicate to high titers in cultured cells, making it an excellent candidate for studying...
Verzijl, Dennis, Fitzsimons, Carlos P., Van Dijk, Marie, Stewart, James P., Timmerman, Henk, Smit, Martine J., ...
Infection of mice with murine gammaherpesvirus 68 (MHV-68) is a well-characterized small animal model for the study of gammaherpesvirus infection. MHV-68 belongs to the same herpesvirus family as...
Douglas, Jill, Dutia, Bernadette, Rhind, Susan, Stewart, James P., Talbot, Simon J.
Murid herpesvirus 4 (commonly called MHV-68) is closely related to Kaposi's sarcoma-associated herpesvirus (KSHV) and provides an excellent model system for investigating gammaherpesvirus-associated...
Obar, Joshua J., Donovan, Douglas C., Crist, Sarah G., Silvia, Ondine, Stewart, James P., Usherwood, Edward J.
DNA vaccination with the M3 gene, encoding an immune evasion molecule expressed during both the acute lytic and persistent phases of murid gammaherpesvirus 68 infection, yielded a significantly lower...
Stewart, James P., Silvia, Ondine J., Atkin, Isobel M. D., Hughes, David J., Ebrahimi, Bahram, Adler, Heiko
The human gammaherpesviruses Epstein-Barr virus and Kaposi Sarcoma-associated herpesvirus both contain a glycoprotein (gp350/220 and K8.1, respectively) that mediates binding to target cells and has...
Husain, S. Mazher, Usherwood, Edward J., Dyson, Heather, Coleclough, Christopher, Coppola, Michael A., Woodland, David L., ...
Murine gammaherpesvirus 68 (MHV-68) infection of mice is a potential model with which to address fundamental aspects of the pathobiology and host control of gammaherpesvirus latency. Control of...
Rta of Murine Gammaherpesvirus 68 Reactivates the Complete Lytic Cycle from Latency
Wu, Ting-Ting, Usherwood, Edward J., Stewart, James P., Nash, Anthony A., Sun, Ren
Herpesviruses are characterized as having two distinct life cycle phases: lytic replication and latency. The mechanisms of latency establishment and maintenance, as well as the switch from latency to...
Macrae, Alastair I., Dutia, Bernadette M., Milligan, Steven, Brownstein, David G., Allen, Deborah J., Mistrikova, Jela, ...
Role of Tachykinins in the Host Response to Murine Gammaherpesvirus Infection
Payne, Catherine M., Heggie, Caroline J., Brownstein, David G., Stewart, James P., Quinn, John P.
Tachykinins function not only as neurotransmitters but also as immunological mediators. We used infection of tachykinin-deficient (PPT-A−/−) mice and wild-type controls with murine...
Macrae, Alastair I., Dutia, Bernadette M., Milligan, Steven, Brownstein, David G., Allen, Deborah J., Mistrikova, Jela, ...
Infection of mice by murine gammaherpesvirus 68 (MHV-68) is an excellent small-animal model of gammaherpesvirus pathogenesis in a natural host. We have carried out comparative studies of another...
Latent Antigen Vaccination in a Model Gammaherpesvirus Infection
Usherwood, Edward J., Ward, Kimberley A., Blackman, Marcia A., Stewart, James P., Woodland, David L.
Vaccines that can reduce the load of latent gammaherpesvirus infections are eagerly sought. One attractive strategy is vaccination against latency-associated proteins, which may increase the...
Macrae, Alastair I., Usherwood, Edward J., Husain, S. Mazher, Flaño, Emilio, Kim, In-Jeong, Woodland, David L., ...
This work describes analyses of the function of the murid herpesvirus 4 strain 68 (MHV-68) M2 gene. A frameshift mutation was made in the M2 open reading frame that caused premature termination of...
Identification of Proteins Associated with Murine Gammaherpesvirus 68 Virions
Bortz, Eric, Whitelegge, Julian P., Jia, Qingmei, Zhou, Z. Hong, Stewart, James P., Wu, Ting-Ting, ...
Murine gammaherpesvirus 68 (MHV68 [also known as γHV-68]) is distinguished by its ability to replicate to high titers in cultured cells, making it an excellent candidate for studying...
Verzijl, Dennis, Fitzsimons, Carlos P., Van Dijk, Marie, Stewart, James P., Timmerman, Henk, Smit, Martine J., ...
Infection of mice with murine gammaherpesvirus 68 (MHV-68) is a well-characterized small animal model for the study of gammaherpesvirus infection. MHV-68 belongs to the same herpesvirus family as...
Douglas, Jill, Dutia, Bernadette, Rhind, Susan, Stewart, James P., Talbot, Simon J.
Murid herpesvirus 4 (commonly called MHV-68) is closely related to Kaposi's sarcoma-associated herpesvirus (KSHV) and provides an excellent model system for investigating gammaherpesvirus-associated...
Obar, Joshua J., Donovan, Douglas C., Crist, Sarah G., Silvia, Ondine, Stewart, James P., Usherwood, Edward J.
DNA vaccination with the M3 gene, encoding an immune evasion molecule expressed during both the acute lytic and persistent phases of murid gammaherpesvirus 68 infection, yielded a significantly lower...
Stewart, James P., Silvia, Ondine J., Atkin, Isobel M. D., Hughes, David J., Ebrahimi, Bahram, Adler, Heiko
The human gammaherpesviruses Epstein-Barr virus and Kaposi Sarcoma-associated herpesvirus both contain a glycoprotein (gp350/220 and K8.1, respectively) that mediates binding to target cells and has...
Hanamura, Ichiro, Stewart, James P., Huang, Yongsheng, Zhan, Fenghuang, Santra, Madhumita, Sawyer, Jeffrey R., ...
Using fluorescence in situ hybridization we investigated amplification of chromosome band 1q21 (Amp1q21) in more than 500 untreated patients with monoclonal gammopathy of undetermined significance...
The molecular classification of multiple myeloma
Zhan, Fenghuang, Huang, Yongsheng, Colla, Simona, Stewart, James P., Hanamura, Ichiro, Gupta, Sushil, ...
To better define the molecular basis of multiple myeloma (MM), we performed unsupervised hierarchic clustering of mRNA expression profiles in CD138-enriched plasma cells from 414 newly diagnosed...
Semple, Malcolm G., Dankert, Hinke M., Ebrahimi, Bahram, Correia, Jailson B., Booth, J. Angela, Stewart, James P., ...
Identification of Novel Rodent Herpesviruses, Including the First Gammaherpesvirus of Mus musculus▿
Ehlers, Bernhard, Küchler, Judit, Yasmum, Nezlisah, Dural, Güzin, Voigt, Sebastian, Schmidt-Chanasit, Jonas, ...
Rodent herpesviruses such as murine cytomegalovirus (host, Mus musculus), rat cytomegalovirus (host, Rattus norvegicus), and murine gammaherpesvirus 68 (hosts, Apodemus species) are important tools...
Induction of Tachykinin Production in Airway Epithelia in Response to Viral Infection
Stewart, James P., Kipar, Anja, Cox, Helen, Payne, Catherine, Vasiliou, Sylvia, Quinn, John P.
Control of Gammaherpesvirus Latency by Latent Antigen-Specific Cd8+ T Cells
Usherwood, Edward J., Roy, Douglas J., Ward, Kim, Surman, Sherri L., Dutia, Bernadette M., Blackman, Marcia A., ...
The contribution of the latent antigen-specific CD8+ T cell response to the control of gammaherpesvirus latency is currently obscure. Some latent antigens induce potent T cell responses, but little...
Lung Epithelial Cells Are a Major Site of Murine Gammaherpesvirus Persistence
Stewart, James P., Usherwood, Edward J., Ross, Alan, Dyson, Heather, Nash, Tony
It is currently believed that latently infected, resting B lymphocytes are central to gammaherpesvirus persistence, whereas mucosal epithelial cells are considered nonessential. We have readdressed...
Zhan, Fenghuang, Colla, Simona, Wu, Xiaosong, Chen, Bangzheng, Stewart, James P., Kuehl, W. Michael, ...
Overexpression of CKS1B, a gene mapping within a minimally amplified region between 153 to 154 Mb of chromosome 1q21, is linked to a poor prognosis in multiple myeloma (MM). CKS1B binds to and...
Proteomic Analysis of Pathogenic and Attenuated Alcelaphine Herpesvirus 1▿
Dry, Inga, Haig, David M., Inglis, Neil F., Imrie, Lisa, Stewart, James P., Russell, George C.
The gammaherpesvirus alcelaphine herpesvirus 1 (AlHV-1) causes malignant catarrhal fever in susceptible ungulates but infects its natural host, wildebeest, without obvious clinical signs. In tissue...