Molecular Recognition in Gels, Monolayers, and Solids (2000)
Prime, Kevin L., Chu, Yen-Ho, Schmid, Walther, Seto, Christopher T., Chen, James K.
This paper describes work in four area:affinity electrophoresis of carbonic anhydrase in cross-linked polyacrylamide-derived gels containing immobilized derivatives of aryl sulfonamides; inhibition...
Small molecule modulation of Smoothened activity
Chen, James K., Taipale, Jussi, Young, Keith E., Maiti, Tapan, Beachy, Philip A.
Smoothened (Smo), a distant relative of G protein-coupled receptors, mediates Hedgehog (Hh) signaling during embryonic development and can initiate or transmit ligand-independent pathway activation...
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
Chen, James K., Taipale, Jussi, Cooper, Michael K., Beachy, Philip A.
The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from its ability to specifically block cellular responses to vertebrate Hedgehog signaling. We show here,...
Small molecule modulation of Smoothened activity
Chen, James K., Taipale, Jussi, Young, Keith E., Maiti, Tapan, Beachy, Philip A.
Smoothened (Smo), a distant relative of G protein-coupled receptors, mediates Hedgehog (Hh) signaling during embryonic development and can initiate or transmit ligand-independent pathway activation...
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
Chen, James K., Taipale, Jussi, Cooper, Michael K., Beachy, Philip A.
The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from its ability to specifically block cellular responses to vertebrate Hedgehog signaling. We show here,...
Smoothened Signal Transduction Is Promoted by G Protein-Coupled Receptor Kinase 2▿
Meloni, Alison R., Fralish, Gregory B., Kelly, Patrick, Salahpour, Ali, Chen, James K., Wechsler-Reya, Robert J., ...
Deregulation of the Sonic hedgehog pathway has been implicated in an increasing number of human cancers. In this pathway, the seven-transmembrane (7TM) signaling protein Smoothened regulates cellular...