The Caenorhabditis chemoreceptor gene families (2008)
Thomas, James H, Robertson, Hugh M
Abstract Background Chemoreceptor proteins mediate the first step in the transduction of environmental chemical stimuli, defining the breadth of detection and conferring stimulus specificity. Animal...
Greiner, Leo C., Matis, Howard S., Ritter, Hans G., Rose, Andrew A., Stezelberger, Thorsten, Sun, Xiangming, ...
We describe a three Mimostar-2 Monolithic Active Pixel Sensor (MAPS) sensor telescope prototype with an accompanying readout system incorporating on-the-fly data sparsification. The system has been...
Evolutionary conservation of regulated longevity assurance mechanisms (2007)
McElwee, Joshua J, Schuster, Eugene, Blanc, Eric, Piper, Matthew D, Thomas, James H, Patel, Dhaval S, ...
Abstract Background To what extent are the determinants of aging in animal species universal? Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) is an evolutionarily conserved (public)...
Rapid Birth–Death Evolution Specific to Xenobiotic Cytochrome P450 Genes in Vertebrates (2007)
Genes vary greatly in their long-term phylogenetic stability and there exists no general explanation for these differences. The cytochrome P450 (CYP450) gene superfamily is well suited to...
Managing Risk to the National Information Infrastructure (1998)
Now, more than ever, the survival of our information based society depends on the integrity of our National Information Infrastructure (NII). Our information systems are vulnerable to a wide spectrum...
A History of Land Tenure Arrangements in Northern Ireland (1997)
"This paper examines the history of land tenure arrangements in Northern Ireland. Much of the literature on land tenure systems suggests that a fixed tenure system will promote economic activity and...
Field project.
A pictured-key of the more conspicuous springflora for biology students in the Morenci area. (1953)
Practicum (M.A. Ed.)--Arizona State University, 1953--Biology.
Document ID: sl634
Document ID: sl634
Neurosecretory control of aging in Caenorhabditis elegans
Ailion, Michael, Inoue, Takao, Weaver, Carole I., Holdcraft, Robert W., Thomas, James H.
In the nematode Caenorhabditis elegans, an insulin receptor signaling pathway regulates adult life span and developmental arrest at the dauer larval stage. Here we show that the unc-64 and unc-31...
Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa
Darby, Creg, Cosma, Christine L., Thomas, James H., Manoil, Colin
Identification of host factors that interact with pathogens is crucial to an understanding of infectious disease, but direct screening for host mutations to aid in this task is not feasible in...
Schafer, Jenny C., Haycraft, Courtney J., Thomas, James H., Yoder, Bradley K., Swoboda, Peter
Intraflagellar transport (IFT) is a process required for flagella and cilia assembly that describes the dynein and kinesin mediated movement of particles along axonemes that consists of an A and a B...
Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy
Kraemer, Brian C., Zhang, Bin, Leverenz, James B., Thomas, James H., Trojanowski, John Q., Schellenberg, Gerard D.
Frontotemporal dementia with parkinsonism chromosome 17 type (FTDP-17) is caused by mutations in MAPT, the gene encoding tau. FTDP-17 begins with executive function deficits and other abnormal...
Paradis, Suzanne, Ailion, Michael, Toker, Alex, Thomas, James H., Ruvkun, Gary
An insulin receptor-like signaling pathway regulates Caenorhabditis elegans metabolism, development, and longevity. Inactivation of the insulin receptor homolog DAF-2, the AGE-1 PI3K, or the AKT-1...
Petersen, Christina I., McFarland, Toni R., Stepanovic, Svetlana Z., Yang, Ping, Reiner, David J., Hayashi, Kenshi, ...
Human ether-a-go-go-related gene (HERG) encodes the pore-forming subunit of IKr, a cardiac K+ channel. Although many commonly used drugs block IKr, in certain individuals, this action evokes a...
Thomas, James H., Kelley, Joanna L., Robertson, Hugh M., Ly, Kim, Swanson, Willie J.
We investigated the possibility of positive selection acting on members of the putative seven-pass chemoreceptor superfamily in Caenorhabditis elegans, which comprises ≈1,300 genes encoding...
Isolation and Characterization of Mutations in the β-Tubulin Gene of SACCHAROMYCES CEREVISIAE
Thomas, James H., Neff, Norma F., Botstein, David
Of 173 mutants of Saccharomyces cerevisiae resistant to the antimitotic drug benomyl (BenR), six also conferred cold-sensitivity for growth and three others conferred temperature-sensitivity for...
Thomas, James H., Botstein, David
Diploid Saccharomyces cerevisiae strains normally sporulate to produce tetrahedral unordered asci containing four spores (tetrads). We report that when newly formed zygotes are subjected to the same...
High Genetic Diversity in the Chemoreceptor Superfamily of Caenorhabditis elegans
Stewart, Mary K., Clark, Nathaniel L., Merrihew, Gennifer, Galloway, Evan M., Thomas, James H.
We investigated genetic polymorphism in the Caenorhabditis elegans srh and str chemoreceptor gene families, each of which consists of ∼300 genes encoding seven-pass G-protein-coupled receptors....
An algorithm for detecting local clusters of homologous genes was applied to the genome of Caenorhabditis elegans. Clusters of two or more homologous genes are abundant, totaling 1391 clusters...
Choy, Robert K. M., Kemner, John M., Thomas, James H.
Fluoxetine (Prozac) is one of the most widely prescribed pharmaceuticals, yet important aspects of its mechanism of action remain unknown. We previously reported that fluoxetine and related...
Concerted Evolution of Two Novel Protein Families in Caenorhabditis Species
Among a large number of homologous gene clusters in C. elegans, two gene families that appear to undergo concerted evolution were studied in detail. Both gene families are nematode specific and...
Ailion, Michael, Thomas, James H
Dauer formation in Caenorhabditis elegans is regulated by at least three signaling pathways, including an insulin receptor-signaling pathway. These pathways were defined by mutants that form dauers...
Neurosecretory control of aging in Caenorhabditis elegans
Ailion, Michael, Inoue, Takao, Weaver, Carole I., Holdcraft, Robert W., Thomas, James H.
In the nematode Caenorhabditis elegans, an insulin receptor signaling pathway regulates adult life span and developmental arrest at the dauer larval stage. Here we show that the unc-64 and unc-31...
Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa
Darby, Creg, Cosma, Christine L., Thomas, James H., Manoil, Colin
Identification of host factors that interact with pathogens is crucial to an understanding of infectious disease, but direct screening for host mutations to aid in this task is not feasible in...
Schafer, Jenny C., Haycraft, Courtney J., Thomas, James H., Yoder, Bradley K., Swoboda, Peter
Intraflagellar transport (IFT) is a process required for flagella and cilia assembly that describes the dynein and kinesin mediated movement of particles along axonemes that consists of an A and a B...
Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy
Kraemer, Brian C., Zhang, Bin, Leverenz, James B., Thomas, James H., Trojanowski, John Q., Schellenberg, Gerard D.
Frontotemporal dementia with parkinsonism chromosome 17 type (FTDP-17) is caused by mutations in MAPT, the gene encoding tau. FTDP-17 begins with executive function deficits and other abnormal...
Paradis, Suzanne, Ailion, Michael, Toker, Alex, Thomas, James H., Ruvkun, Gary
An insulin receptor-like signaling pathway regulates Caenorhabditis elegans metabolism, development, and longevity. Inactivation of the insulin receptor homolog DAF-2, the AGE-1 PI3K, or the AKT-1...
Petersen, Christina I., McFarland, Toni R., Stepanovic, Svetlana Z., Yang, Ping, Reiner, David J., Hayashi, Kenshi, ...
Human ether-a-go-go-related gene (HERG) encodes the pore-forming subunit of IKr, a cardiac K+ channel. Although many commonly used drugs block IKr, in certain individuals, this action evokes a...
Thomas, James H., Kelley, Joanna L., Robertson, Hugh M., Ly, Kim, Swanson, Willie J.
We investigated the possibility of positive selection acting on members of the putative seven-pass chemoreceptor superfamily in Caenorhabditis elegans, which comprises ≈1,300 genes encoding...
Isolation and Characterization of Mutations in the β-Tubulin Gene of SACCHAROMYCES CEREVISIAE
Thomas, James H., Neff, Norma F., Botstein, David
Of 173 mutants of Saccharomyces cerevisiae resistant to the antimitotic drug benomyl (BenR), six also conferred cold-sensitivity for growth and three others conferred temperature-sensitivity for...
Thomas, James H., Botstein, David
Diploid Saccharomyces cerevisiae strains normally sporulate to produce tetrahedral unordered asci containing four spores (tetrads). We report that when newly formed zygotes are subjected to the same...
High Genetic Diversity in the Chemoreceptor Superfamily of Caenorhabditis elegans
Stewart, Mary K., Clark, Nathaniel L., Merrihew, Gennifer, Galloway, Evan M., Thomas, James H.
We investigated genetic polymorphism in the Caenorhabditis elegans srh and str chemoreceptor gene families, each of which consists of ∼300 genes encoding seven-pass G-protein-coupled receptors....
An algorithm for detecting local clusters of homologous genes was applied to the genome of Caenorhabditis elegans. Clusters of two or more homologous genes are abundant, totaling 1391 clusters...
Choy, Robert K. M., Kemner, John M., Thomas, James H.
Fluoxetine (Prozac) is one of the most widely prescribed pharmaceuticals, yet important aspects of its mechanism of action remain unknown. We previously reported that fluoxetine and related...
Concerted Evolution of Two Novel Protein Families in Caenorhabditis Species
Among a large number of homologous gene clusters in C. elegans, two gene families that appear to undergo concerted evolution were studied in detail. Both gene families are nematode specific and...
Ailion, Michael, Thomas, James H
Dauer formation in Caenorhabditis elegans is regulated by at least three signaling pathways, including an insulin receptor-signaling pathway. These pathways were defined by mutants that form dauers...
Mutator Phenotype of Caenorhabditis elegans DNA Damage Checkpoint Mutants
Harris, Jasper, Lowden, Mia, Clejan, Iuval, Tzoneva, Monika, Thomas, James H., Hodgkin, Jonathan, ...
DNA damage response proteins identify sites of DNA damage and signal to downstream effectors that orchestrate either apoptosis or arrest of the cell cycle and DNA repair. The C. elegans DNA damage...
Adaptive evolution in two large families of ubiquitin-ligase adapters in nematodes and plants
Host–pathogen arms races can result in adaptive evolution (positive selection) of host genes that mediate pathogen recognition and defense. To identify such genes in nematodes, I used...
Identification of a Novel Gene Family Involved in Osmotic Stress Response in Caenorhabditis elegans
Wheeler, Jeanna M., Thomas, James H.
Organisms exposed to the damaging effects of high osmolarity accumulate solutes to increase cytoplasmic osmolarity. Yeast accumulates glycerol in response to osmotic stress, activated primarily by...
Rapid Birth–Death Evolution Specific to Xenobiotic Cytochrome P450 Genes in Vertebrates
Genes vary greatly in their long-term phylogenetic stability and there exists no general explanation for these differences. The cytochrome P450 (CYP450) gene superfamily is well suited to...
Zhao, Zhongying, Thomas, James H., Chen, Nansheng, Sheps, Jonathan A., Baillie, David L.
ABC transporters constitute one of the largest gene families in all species. They are mostly involved in transport of substrates across membranes. We have previously demonstrated that the...
Maydan, Jason S., Flibotte, Stephane, Edgley, Mark L., Lau, Joanne, Selzer, Rebecca R., Richmond, Todd A., ...
We have developed array Comparative Genomic Hybridization for Caenorhabditis elegans as a means of screening for novel induced deletions in this organism. We designed three microarrays consisting of...
Genetic Analysis of Dauer Formation in Caenorhabditis briggsae
Inoue, Takao, Ailion, Michael, Poon, Shirley, Kim, Hannah K., Thomas, James H., Sternberg, Paul W.
Molecular changes that underlie evolutionary changes in behavior and physiology are not well understood. Dauer formation in Caenorhabditis elegans is a temperature-sensitive process controlled...
Evolutionary conservation of regulated longevity assurance mechanisms
McElwee, Joshua J, Schuster, Eugene, Blanc, Eric, Piper, Matthew D, Thomas, James H, Patel, Dhaval S, ...
Short abstract: A multi-level cross-species comparative analysis of gene-expression changes accompanying increased longevity in mutant nematodes, fruit flies and mice with reduced insulin/IGF-1...
Quantitative evidence for conserved longevity pathways between divergent eukaryotic species
Smith, Erica D., Tsuchiya, Mitsuhiro, Fox, Lindsay A., Dang, Nick, Hu, Di, Kerr, Emily O., ...
Studies in invertebrate model organisms have been a driving force in aging research, leading to the identification of many genes that influence life span. Few of these genes have been examined in the...