Holterhus, Paul-Martin, Deppe, Uta, Werner, Ralf, Richter-Unruh, Annette, Bebermeier, Jan-Hendrik, Wünsch, Lutz, ...
Abstract Background To better understand the molecular programs of normal and abnormal genital development, clear-cut definition of androgen-dependent gene expression patterns, without the influence...
Modest induction of phase 2 enzyme activity in the F-344 rat prostate (2006)
Jones, Sunita B, Brooks, James D
Abstract Background Prostate cancer is the most commonly diagnosed malignancy in men and is thought to arise as a result of endogenous oxidative stress in the face of compromised carcinogen defenses....
Gene Expression Profiling Predicts Survival in Conventional Renal Cell Carcinoma (2006)
Hongjuan Zhao, Börje Ljungberg, Kjell Grankvist, Torgny Rasmuson, Robert Tibshirani, James D. Brooks
Molecular heterogeneity of renal cell carcinomas can be used to distinguish subgroups that correlated with long term survival.
Gene Expression Profiling Predicts Survival in Conventional Renal Cell Carcinoma (2006)
Hongjuan Zhao, Börje Ljungberg, Kjell Grankvist, Torgny Rasmuson, Robert Tibshirani, James D. Brooks
Background Conventional renal cell carcinoma (cRCC) accounts for most of the deaths due to kidney cancer. Tumor stage, grade, and patient performance status are used currently to predict survival...
A Transcriptional Profile of Aging in the Human Kidney (2004)
Rebecca Sonu, Jacob M. Zahn, James Lund, Julie Wilhelmy, Lingli Wang, ...
A study of human aging in the kidney reveals similar changes in the transcriptional profile in cortex and medulla, suggesting that a common underlying aging process is taking place.
A Transcriptional Profile of Aging in the Human Kidney (2004)
Rebecca Sonu, Jacob M. Zahn, James Lund, Julie Wilhelmy, Lingli Wang, ...
In this study, we found 985 genes that change expression in the cortex and the medulla of the kidney with age. Some of the genes whose transcripts increase in abundance with age are known to be...
Holterhus, Paul-Martin, Hiort, Olaf, Demeter, Janos, Brown, Patrick O, Brooks, James D
Abstract Background Androgen insensitivity syndrome (AIS) comprises a range of phenotypes from male infertility to complete feminization. Most individuals with AIS carry germline mutations of the...
Patterns Cancer Prevention Through Induction of Phase 2 Enzymes (2003)
Virtually all human prostate cancers lose expression of glutathione S-transferase-II, an enzyme that protects against oxidative electrophiles that attack the DNA and result in cancer. Based on this...
Prostate Cancer Prevention Through Induction of Phase 2 Enzymes (2003)
Virtually all human prostate cancers harbor a common somatically acquired genetic lesion - loss of expression of the carcinogen defense enzyme glutathione S-transferase-pi (GST-pi) due to methylation...
Transcriptional programs activated by exposure of human prostate cancer cells to androgen (2002)
DePrimo, Samuel E, Diehn, Maximilian, Nelson, Joel B, Reiter, Robert E, Matese, John, Fero, Mike, ...
Abstract Background Androgens are required for both normal prostate development and prostate carcinogenesis. We used DNA microarrays, representing approximately 18,000 genes, to examine the temporal...
Prostate Cancer Prevention Through Induction of Phase 2 Enzymes (2002)
Virtually all human prostate cancers lose expression of glutathione S-transferase-n, an enzyme that protects against oxidative electrophiles that attack the DNA and result in cancer. Based on this...
Transcriptional programs activated by exposure of human prostate cancer cells to androgen
DePrimo, Samuel E, Diehn, Maximilian, Nelson, Joel B, Reiter, Robert E, Matese, John, Fero, Mike, ...
DNA microarrays were used to examine the temporal program of gene expression following treatment of a human prostate cancer cell line with androgen. Significant changes in levels of transcripts of...
Holterhus, Paul-Martin, Hiort, Olaf, Demeter, Janos, Brown, Patrick O, Brooks, James D
Most individuals with androgen insensitivity syndrome (AIS) carry germline mutations of the androgen receptor (AR) that interfere with or ablate its function. As genital fibroblasts retain expression...
Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors
Sperger, Jamie M., Chen, Xin, Draper, Jonathan S., Antosiewicz, Jessica E., Chon, Chris H., Jones, Sunita B., ...
Remarkably little is known about the transcriptional profiles of human embryonic stem (ES) cells or the molecular mechanisms that underlie their pluripotency. To identify commonalties among the...
Gene expression profiling identifies clinically relevant subtypes of prostate cancer
Lapointe, Jacques, Li, Chunde, Higgins, John P., Van De Rijn, Matt, Bair, Eric, Montgomery, Kelli, ...
Prostate cancer, a leading cause of cancer death, displays a broad range of clinical behavior from relatively indolent to aggressive metastatic disease. To explore potential molecular variation...
Zhao, Hongjuan, Whitfield, Michael L., Xu, Tong, Botstein, David, Brooks, James D.
Methylseleninic acid (MSA) has been shown to have potent anticancer activity and is an excellent compound for studying the anticancer effects of selenium in vitro. To gain insights into the effects...
Gene Expression in the Normal Adult Human Kidney Assessed by Complementary DNA Microarray
Higgins, John P.T., Wang, Lingli, Kambham, Neeraja, Montgomery, Kelli, Mason, Veronica, Vogelmann, Stefanie U., ...
The kidney is a highly specialized organ with a complex, stereotyped architecture and a great diversity of functions and cell types. Because the microscopic organization of the nephron, the...
A Transcriptional Profile of Aging in the Human Kidney
Rodwell, Graham E. J, Sonu, Rebecca, Zahn, Jacob M, Lund, James, Wilhelmy, Julie, Wang, Lingli, ...
In this study, we found 985 genes that change expression in the cortex and the medulla of the kidney with age. Some of the genes whose transcripts increase in abundance with age are known to be...
Gene Expression Profiling Predicts Survival in Conventional Renal Cell Carcinoma
Zhao, Hongjuan, Ljungberg, Börje, Grankvist, Kjell, Rasmuson, Torgny, Tibshirani, Robert, Brooks, James D
Molecular heterogeneity of renal cell carcinomas can be used to distinguish subgroups that correlated with long term survival.
Transcriptional programs activated by exposure of human prostate cancer cells to androgen
DePrimo, Samuel E, Diehn, Maximilian, Nelson, Joel B, Reiter, Robert E, Matese, John, Fero, Mike, ...
DNA microarrays were used to examine the temporal program of gene expression following treatment of a human prostate cancer cell line with androgen. Significant changes in levels of transcripts of...
Holterhus, Paul-Martin, Hiort, Olaf, Demeter, Janos, Brown, Patrick O, Brooks, James D
Most individuals with androgen insensitivity syndrome (AIS) carry germline mutations of the androgen receptor (AR) that interfere with or ablate its function. As genital fibroblasts retain expression...
Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors
Sperger, Jamie M., Chen, Xin, Draper, Jonathan S., Antosiewicz, Jessica E., Chon, Chris H., Jones, Sunita B., ...
Remarkably little is known about the transcriptional profiles of human embryonic stem (ES) cells or the molecular mechanisms that underlie their pluripotency. To identify commonalties among the...
Gene expression profiling identifies clinically relevant subtypes of prostate cancer
Lapointe, Jacques, Li, Chunde, Higgins, John P., Van De Rijn, Matt, Bair, Eric, Montgomery, Kelli, ...
Prostate cancer, a leading cause of cancer death, displays a broad range of clinical behavior from relatively indolent to aggressive metastatic disease. To explore potential molecular variation...
Zhao, Hongjuan, Whitfield, Michael L., Xu, Tong, Botstein, David, Brooks, James D.
Methylseleninic acid (MSA) has been shown to have potent anticancer activity and is an excellent compound for studying the anticancer effects of selenium in vitro. To gain insights into the effects...
Gene Expression in the Normal Adult Human Kidney Assessed by Complementary DNA Microarray
Higgins, John P.T., Wang, Lingli, Kambham, Neeraja, Montgomery, Kelli, Mason, Veronica, Vogelmann, Stefanie U., ...
The kidney is a highly specialized organ with a complex, stereotyped architecture and a great diversity of functions and cell types. Because the microscopic organization of the nephron, the...
A Transcriptional Profile of Aging in the Human Kidney
Rodwell, Graham E. J, Sonu, Rebecca, Zahn, Jacob M, Lund, James, Wilhelmy, Julie, Wang, Lingli, ...
In this study, we found 985 genes that change expression in the cortex and the medulla of the kidney with age. Some of the genes whose transcripts increase in abundance with age are known to be...
Gene Expression Profiling Predicts Survival in Conventional Renal Cell Carcinoma
Zhao, Hongjuan, Ljungberg, Börje, Grankvist, Kjell, Rasmuson, Torgny, Tibshirani, Robert, Brooks, James D
Molecular heterogeneity of renal cell carcinomas can be used to distinguish subgroups that correlated with long term survival.
A promoting role of androgen receptor in androgen-sensitive and -insensitive prostate cancer cells
Li, Tzu-Huey, Zhao, Hongjuan, Peng, Yue, Beliakoff, Jason, Brooks, James D., Sun, Zijie
Although the vital role of the androgen receptor (AR) has been well demonstrated in primary prostate cancers, its role in the androgen-insensitive prostate cancers still remains unclear. Here, we...
Lin, Xiaohui, Tascilar, Metin, Lee, Wen-Hsiang, Vles, Wouter J., Lee, Byron H., Veeraswamy, Ravi, ...
GSTP1 CpG island hypermethylation is the most common somatic genome alteration described for human prostate cancer (PCA); lack of GSTP1 expression is characteristic of human PCA cells in vivo. We...
Gene Expression Patterns in Renal Cell Carcinoma Assessed by Complementary DNA Microarray
Higgins, John P.T., Shinghal, Rajesh, Gill, Harcharan, Reese, Jeffrey H., Terris, Martha, Cohen, Ronald J., ...
Renal cell carcinoma comprises several histological types with different clinical behavior. Accurate pathological characterization is important in the clinical management of these tumors. We describe...