James A. Wechsler

Isolation and Characterization of Thermosensitive Escherichia coli Mutants Defective in Deoxyribonucleic Acid Replication

Wechsler, James A., Nüsslein, Volker, Otto, Bernd, Klein, Albrecht, Bonhoeffer, Friedrich, Herrmann, Richard, ...

Thermosensitive deoxyribonucleic acid replication-defective mutants have been isolated by using an autoradiographic selection method. The mutants have been analyzed genetically and biochemically....

Antipolarity in the ilv Operon of Escherichia coli K-12

Wechsler, James A., Adelberg, E. A.

The genes governing three of the enzymes of the isoleucine-valine biosynthetic pathway form the operon: operator-ilvA-ilvD-ilvE. The enzymes are: ilvA, l-threonine deaminase; ilvD, dihydroxy acid...

Analysis of DNA Polymerases II and III in Mutants of Escherichia coli Thermosensitive for DNA Synthesis

Gefter, Malcolm L., Hirota, Yukinori, Kornberg, Thomas, Wechsler, James A., Barnoux, C.

A series of double mutants carrying one of the thermosensitive mutations for DNA synthesis (dnaA, B, C, D, E, F, and G) and the polA1 mutation of DeLucia and Cairns, were constructed. Enzyme...

High Frequency of Genetic Duplications in the dnaB Region of the ESCHERICHIA COLI K12 Chromosome

Sclafani, Robert A., Wechsler, James A.

The region that includes the dnaB locus on the E. coli K12 chromosome was shown to be duplicated at high frequency in cell populations. The duplications were shown to be arranged in tandem and...

Isolation and Characterization of Thermosensitive Escherichia coli Mutants Defective in Deoxyribonucleic Acid Replication

Wechsler, James A., Nüsslein, Volker, Otto, Bernd, Klein, Albrecht, Bonhoeffer, Friedrich, Herrmann, Richard, ...

Thermosensitive deoxyribonucleic acid replication-defective mutants have been isolated by using an autoradiographic selection method. The mutants have been analyzed genetically and biochemically....

Antipolarity in the ilv Operon of Escherichia coli K-12

Wechsler, James A., Adelberg, E. A.

The genes governing three of the enzymes of the isoleucine-valine biosynthetic pathway form the operon: operator-ilvA-ilvD-ilvE. The enzymes are: ilvA, l-threonine deaminase; ilvD, dihydroxy acid...

Analysis of DNA Polymerases II and III in Mutants of Escherichia coli Thermosensitive for DNA Synthesis

Gefter, Malcolm L., Hirota, Yukinori, Kornberg, Thomas, Wechsler, James A., Barnoux, C.

A series of double mutants carrying one of the thermosensitive mutations for DNA synthesis (dnaA, B, C, D, E, F, and G) and the polA1 mutation of DeLucia and Cairns, were constructed. Enzyme...

High Frequency of Genetic Duplications in the dnaB Region of the ESCHERICHIA COLI K12 Chromosome

Sclafani, Robert A., Wechsler, James A.

The region that includes the dnaB locus on the E. coli K12 chromosome was shown to be duplicated at high frequency in cell populations. The duplications were shown to be arranged in tandem and...