Horizontal gene transfer among genomes: The complexity hypothesis
Jain, Ravi, Rivera, Maria C., Lake, James A.
Increasingly, studies of genes and genomes are indicating that considerable horizontal transfer has occurred between prokaryotes. Extensive horizontal transfer has occurred for operational genes...
Genomic evidence for two functionally distinct gene classes
Rivera, Maria C., Jain, Ravi, Moore, Jonathan E., Lake, James A.
Analyses of complete genomes indicate that a massive prokaryotic gene transfer (or transfers) preceded the formation of the eukaryotic cell. In comparisons of the entire set of Methanococcus...
A type IB topoisomerase with DNA repair activities
Belova, Galina I., Prasad, Rajendra, Kozyavkin, Sergei A., Lake, James A., Wilson, Samuel H., Slesarev, Alexei I.
Previously we have characterized type IB DNA topoisomerase V (topo V) in the hyperthermophile Methanopyrus kandleri. The enzyme has a powerful topoisomerase activity and is abundant in M. kandleri....
Gene structure prediction in syntenic DNA segments
Moore, Jonathan E., Lake, James A.
The accurate prediction of higher eukaryotic gene structures and regulatory elements directly from genomic sequences is an important early step in the understanding of newly assembled contigs and...
Localization of eukaryotic initiation factor 3 on native small ribosomal subunits
Emanuilov, Ivan, Sabatini, David D., Lake, James A., Freienstein, Christoph
The localization of eukaryotic initiation factor 3(eIF-3) on native small ribosomal subunits has been established by electron microscopy through a comparison of native small ribosomal subunits with...
Lake, James A., Pendergast, Maryanne, Kahan, Lawrence, Nomura, Masayasu
Binding sites for antibodies specific for proteins S4 and S14 of the small subunit of E. coli ribosomes have been mapped on the surface of the subunit by electron microscopy. Antibody binding to...
Decoding the genomic tree of life
Simonson, Anne B., Servin, Jacqueline A., Skophammer, Ryan G., Herbold, Craig W., Rivera, Maria C., Lake, James A.
Genomes hold within them the record of the evolution of life on Earth. But genome fusions and horizontal gene transfer (HGT) seem to have obscured sufficiently the gene sequence record such that it...
Horizontal gene transfer among genomes: The complexity hypothesis
Jain, Ravi, Rivera, Maria C., Lake, James A.
Increasingly, studies of genes and genomes are indicating that considerable horizontal transfer has occurred between prokaryotes. Extensive horizontal transfer has occurred for operational genes...
Genomic evidence for two functionally distinct gene classes
Rivera, Maria C., Jain, Ravi, Moore, Jonathan E., Lake, James A.
Analyses of complete genomes indicate that a massive prokaryotic gene transfer (or transfers) preceded the formation of the eukaryotic cell. In comparisons of the entire set of Methanococcus...
A type IB topoisomerase with DNA repair activities
Belova, Galina I., Prasad, Rajendra, Kozyavkin, Sergei A., Lake, James A., Wilson, Samuel H., Slesarev, Alexei I.
Previously we have characterized type IB DNA topoisomerase V (topo V) in the hyperthermophile Methanopyrus kandleri. The enzyme has a powerful topoisomerase activity and is abundant in M. kandleri....
Gene structure prediction in syntenic DNA segments
Moore, Jonathan E., Lake, James A.
The accurate prediction of higher eukaryotic gene structures and regulatory elements directly from genomic sequences is an important early step in the understanding of newly assembled contigs and...
Localization of eukaryotic initiation factor 3 on native small ribosomal subunits
Emanuilov, Ivan, Sabatini, David D., Lake, James A., Freienstein, Christoph
The localization of eukaryotic initiation factor 3(eIF-3) on native small ribosomal subunits has been established by electron microscopy through a comparison of native small ribosomal subunits with...
Lake, James A., Pendergast, Maryanne, Kahan, Lawrence, Nomura, Masayasu
Binding sites for antibodies specific for proteins S4 and S14 of the small subunit of E. coli ribosomes have been mapped on the surface of the subunit by electron microscopy. Antibody binding to...
Decoding the genomic tree of life
Simonson, Anne B., Servin, Jacqueline A., Skophammer, Ryan G., Herbold, Craig W., Rivera, Maria C., Lake, James A.
Genomes hold within them the record of the evolution of life on Earth. But genome fusions and horizontal gene transfer (HGT) seem to have obscured sufficiently the gene sequence record such that it...
An ancestral nuclear protein assembly: Crystal structure of the Methanopyrus kandleri histone
Fahrner, Richard L., Cascio, Duilio, Lake, James A., Slesarev, Alexei
Eukaryotic histone proteins condense DNA into compact structures called nucleosomes. Nucleosomes were viewed as a distinguishing feature of eukaryotes prior to ideication of histone orthologs in...