Metz, Alexandra, Soret, Johann, Vourc'H, Claire, Tazi, Jamal, Jolly, Caroline
Exposure of cells to stressful conditions results in the rapid synthesis of a subset of specialized proteins termed heat shock proteins (HSPs) which function in protecting the cell against damage....
Metz, Alexandra, Soret, Johann, Vourc'H, Claire, Tazi, Jamal, Jolly, Caroline
Exposure of cells to stressful conditions results in the rapid synthesis of a subset of specialized proteins termed heat shock proteins (HSPs) which function in protecting the cell against damage....
Baldin, Véronique, Militello, Muriel, Thomas, Yann, Doucet, Christine, Fic, Weronika, Boireau, Stephanie, ...
In eukaryotic cells, proteasomes play an essential role in intracellular proteolysis and are involved in the control of most biological processes through regulated degradation of key proteins....
Baldin, Véronique, Militello, Muriel, Thomas, Yann, Doucet, Christine, Fic, Weronika, Boireau, Stephanie, ...
In eukaryotic cells, proteasomes play an essential role in intracellular proteolysis and are involved in the control of most biological processes through regulated degradation of key proteins....
Durand, Sébastien, Cougot, Nicolas, Mahuteau-Betzer, Florence, Nguyen, Chi-Hung, Grierson, David, Bertrand, Edouard, ...
In mammals, nonsense-mediated mRNA decay (NMD) is a quality control mechanism that degrades mRNAs harboring a premature termination codon, in order to prevent the synthesis of truncated proteins. To...
Durand, Sébastien, Cougot, Nicolas, Mahuteau-Betzer, Florence, Nguyen, Chi-Hung, Grierson, David, Bertrand, Edouard, ...
In mammals, nonsense-mediated mRNA decay (NMD) is a quality control mechanism that degrades mRNAs harboring a premature termination codon, in order to prevent the synthesis of truncated proteins. To...
Nadia Bakkour, Yea-Lih Lin, Sophie Maire, Lilia Ayadi, Florence Mahuteau-Betzer, Chi Hung Nguyen, ...
The development of multidrug-resistant viruses compromises antiretroviral therapy efficacy and limits therapeutic options. Therefore, it is an ongoing task to identify new targets for antiretroviral...
Mouaikel, John, Narayanan, Usha, Verheggen, C Line, Matera, A. Gregory, Bertrand, Edouard, Tazi, Jamal, ...
The biogenesis of spliceosomal small nuclear ribonucleoproteins (snRNPs) requires the cytoplasmic assembly of the Sm-core complex, followed by the hypermethylation of the small nuclear RNA (snRNA) 5'...
Allemand, Eric, Gattoni, Renata, Bourbon, Henri-Marc, Stevenin, James, Cáceres, Javier F., Soret, Johann, ...
The human splicing factor 2, also called human alternative splicing factor (hASF), is the prototype of the highly conserved SR protein family involved in constitutive and regulated splicing of...
Tourrière, Hélène, Gallouzi, Imed-eddine, Chebli, Karim, Capony, Jean Paul, Mouaikel, John, Van Der Geer, Peter, ...
Mitogen activation of mRNA decay pathways likely involves specific endoribonucleases, such as G3BP, a phosphorylation-dependent endoribonuclease that associates with RasGAP in dividing but not...
Lacroix, Laurent, Liénard, Hélène, Labourier, Emmanuel, Djavaheri-Mergny, Mojgan, Lacoste, Jérôme, Leffers, Henrik, ...
Most studies on the structure of DNA in telomeres have been dedicated to the double-stranded region or the guanosine-rich strand and consequently little is known about the factors that may bind to...
Gallouzi, Imed-eddine, Parker, Fabienne, Chebli, Karim, Maurier, Florence, Labourier, Emmanuel, Barlat, Isabelle, ...
A potential p120 GTPase-activating protein (RasGAP) effector, G3BP (RasGAP Src homology 3 [SH3] binding protein), was previously identified based on its ability to bind the SH3 domain of RasGAP. Here...
Interaction of human DNA topoisomerase I with G-quartet structures
Arimondo, Paola B., Riou, Jean-François, Mergny, Jean-Louis, Tazi, Jamal, Sun, Jian-Sheng, Garestier, Thérèse, ...
Because of their role in the control of the topological state of DNA, topoisomerases are ubiquitous and vital enzymes, which participate in nearly all events related to DNA metabolism including...
Allemand, Eric, Dokudovskaya, Svetlana, Bordonné, Rémy, Tazi, Jamal
Members of the highly conserved serine/arginine-rich (SR) protein family are nuclear factors involved in splicing of metazoan mRNA precursors. In mammals, two nuclear import receptors, transportin...
Sequence–structure–function relationships of Tgs1, the yeast snRNA/snoRNA cap hypermethylase
Mouaikel, John, Bujnicki, Janusz M., Tazi, Jamal, Bordonné, Rémy
The Saccharomyces cerevisiae Tgs1 methyltransferase (MTase) is responsible for conversion of the m7G caps of snRNAs and snoRNAs to a 2,2,7- trimethylguanosine structure. To learn more about the...
Labourier, Emmanuel, Bourbon, Henri-Marc, Gallouzi, Imed-eddine, Fostier, Maggy, Allemand, Eric, Tazi, Jamal
Specific recognition of splice sites within metazoan mRNA precursors (pre-mRNAs) is a potential stage for gene regulation by alternative splicing. Splicing factors of the SR protein family play a...
Gabut, Mathieu, Miné, Manuèle, Marsac, Cécile, Brivet, Michèle, Tazi, Jamal, Soret, Johann
Pyruvate dehydrogenase (PDH) complex deficiency is a major cause of lactic acidosis and Leigh's encephalomyelopathies in infancy and childhood, resulting in early death in the majority of patients....
Soret, Johann, Bakkour, Nadia, Maire, Sophie, Durand, Sébastien, Zekri, Latifa, Gabut, Mathieu, ...
The prevalence of alternative splicing as a target for alterations leading to human genetic disorders makes it highly relevant for therapy. Here we have used in vitro splicing reactions with...
Control of Fetal Growth and Neonatal Survival by the RasGAP-Associated Endoribonuclease G3BP
Zekri, Latifa, Chebli, Karim, Tourrière, Hélène, Nielsen, Finn C., Hansen, Thomas V. O., Rami, Abdelhaq, ...
The regulation of mRNA stability plays a major role in the control of gene expression during cell proliferation, differentiation, and development. Here, we show that inactivation of the...
Mouaikel, John, Narayanan, Usha, Verheggen, Céline, Matera, A. Gregory, Bertrand, Edouard, Tazi, Jamal, ...
The biogenesis of spliceosomal small nuclear ribonucleoproteins (snRNPs) requires the cytoplasmic assembly of the Sm-core complex, followed by the hypermethylation of the small nuclear RNA (snRNA)...
Allemand, Eric, Gattoni, Renata, Bourbon, Henri-Marc, Stevenin, James, Cáceres, Javier F., Soret, Johann, ...
The human splicing factor 2, also called human alternative splicing factor (hASF), is the prototype of the highly conserved SR protein family involved in constitutive and regulated splicing of...
Tourrière, Hélène, Gallouzi, Imed-eddine, Chebli, Karim, Capony, Jean Paul, Mouaikel, John, Van Der Geer, Peter, ...
Mitogen activation of mRNA decay pathways likely involves specific endoribonucleases, such as G3BP, a phosphorylation-dependent endoribonuclease that associates with RasGAP in dividing but not...
Lacroix, Laurent, Liénard, Hélène, Labourier, Emmanuel, Djavaheri-Mergny, Mojgan, Lacoste, Jérôme, Leffers, Henrik, ...
Most studies on the structure of DNA in telomeres have been dedicated to the double-stranded region or the guanosine-rich strand and consequently little is known about the factors that may bind to...
Gallouzi, Imed-eddine, Parker, Fabienne, Chebli, Karim, Maurier, Florence, Labourier, Emmanuel, Barlat, Isabelle, ...
A potential p120 GTPase-activating protein (RasGAP) effector, G3BP (RasGAP Src homology 3 [SH3] binding protein), was previously identified based on its ability to bind the SH3 domain of RasGAP. Here...
Interaction of human DNA topoisomerase I with G-quartet structures
Arimondo, Paola B., Riou, Jean-François, Mergny, Jean-Louis, Tazi, Jamal, Sun, Jian-Sheng, Garestier, Thérèse, ...
Because of their role in the control of the topological state of DNA, topoisomerases are ubiquitous and vital enzymes, which participate in nearly all events related to DNA metabolism including...
Allemand, Eric, Dokudovskaya, Svetlana, Bordonné, Rémy, Tazi, Jamal
Members of the highly conserved serine/arginine-rich (SR) protein family are nuclear factors involved in splicing of metazoan mRNA precursors. In mammals, two nuclear import receptors, transportin...
Sequence–structure–function relationships of Tgs1, the yeast snRNA/snoRNA cap hypermethylase
Mouaikel, John, Bujnicki, Janusz M., Tazi, Jamal, Bordonné, Rémy
The Saccharomyces cerevisiae Tgs1 methyltransferase (MTase) is responsible for conversion of the m7G caps of snRNAs and snoRNAs to a 2,2,7- trimethylguanosine structure. To learn more about the...
Labourier, Emmanuel, Bourbon, Henri-Marc, Gallouzi, Imed-eddine, Fostier, Maggy, Allemand, Eric, Tazi, Jamal
Specific recognition of splice sites within metazoan mRNA precursors (pre-mRNAs) is a potential stage for gene regulation by alternative splicing. Splicing factors of the SR protein family play a...
Gabut, Mathieu, Miné, Manuèle, Marsac, Cécile, Brivet, Michèle, Tazi, Jamal, Soret, Johann
Pyruvate dehydrogenase (PDH) complex deficiency is a major cause of lactic acidosis and Leigh's encephalomyelopathies in infancy and childhood, resulting in early death in the majority of patients....
Soret, Johann, Bakkour, Nadia, Maire, Sophie, Durand, Sébastien, Zekri, Latifa, Gabut, Mathieu, ...
The prevalence of alternative splicing as a target for alterations leading to human genetic disorders makes it highly relevant for therapy. Here we have used in vitro splicing reactions with...
Control of Fetal Growth and Neonatal Survival by the RasGAP-Associated Endoribonuclease G3BP
Zekri, Latifa, Chebli, Karim, Tourrière, Hélène, Nielsen, Finn C., Hansen, Thomas V. O., Rami, Abdelhaq, ...
The regulation of mRNA stability plays a major role in the control of gene expression during cell proliferation, differentiation, and development. Here, we show that inactivation of the...
Mouaikel, John, Narayanan, Usha, Verheggen, Céline, Matera, A. Gregory, Bertrand, Edouard, Tazi, Jamal, ...
The biogenesis of spliceosomal small nuclear ribonucleoproteins (snRNPs) requires the cytoplasmic assembly of the Sm-core complex, followed by the hypermethylation of the small nuclear RNA (snRNA)...
Eye Development under the control of SRp55/B52-Mediated Alternative Splicing of eyeless
Fic, Weronika, Juge, François, Soret, Johann, Tazi, Jamal
The genetic programs specifying eye development are highly conserved during evolution and involve the vertebrate Pax-6 gene and its Drosophila melanogaster homolog eyeless (ey). Here we report that...
Gabut, Mathieu, Dejardin, Jérôme, Tazi, Jamal, Soret, Johann
Deciphering the role of alternative splicing in developmental processes relies on the identification of key genes whose expression is controlled by splicing regulators throughout the growth of a...
Bakkour, Nadia, Lin, Yea-Lih, Maire, Sophie, Ayadi, Lilia, Mahuteau-Betzer, Florence, Nguyen, Chi Hung, ...
The development of multidrug-resistant viruses compromises antiretroviral therapy efficacy and limits therapeutic options. Therefore, it is an ongoing task to identify new targets for antiretroviral...
Durand, Sébastien, Cougot, Nicolas, Mahuteau-Betzer, Florence, Nguyen, Chi-Hung, Grierson, David S., Bertrand, Edouard, ...
In mammals, nonsense-mediated mRNA decay (NMD) is a quality-control mechanism that degrades mRNA harboring a premature termination codon to prevent the synthesis of truncated proteins. To gain...
The RasGAP-associated endoribonuclease G3BP assembles stress granules
Tourrière, Hélène, Chebli, Karim, Zekri, Latifa, Courselaud, Brice, Blanchard, Jean Marie, Bertrand, Edouard, ...
Stress granules (SGs) are formed in the cytoplasm in response to various toxic agents, and are believed to play a critical role in the regulation of mRNA metabolism during stress. In SGs, mRNAs are...
A Novel Role for PA28γ-Proteasome in Nuclear Speckle Organization and SR Protein Trafficking
Baldin, Véronique, Militello, Muriel, Thomas, Yann, Doucet, Christine, Fic, Weronika, Boireau, Stephanie, ...
In eukaryotic cells, proteasomes play an essential role in intracellular proteolysis and are involved in the control of most biological processes through regulated degradation of key proteins....