Jahn M. Nesland

The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas (2008)

Wang, Zhihui, Tropè, Claes G, Suo, Zhenhe, Trøen, Gunhild, Yang, Guanrui, Nesland, Jahn M, ...

Abstract Background 14-3-3 sigma (σ) promotes G2/M cell cycle arrest by sequestering cyclin B1-CDC2 complex in cytoplasm. Down-regulation of 14-3-3σ, which has been demonstrated in various...

DNA methylation profiling of ovarian carcinomas and their in vitromodels identifies HOXA9, HOXB5, SCGB3A1, and CRABP1as novel targets (2007)

Wu, Qinghua, Lothe, Ragnhild A, Ahlquist, Terje, Silins, Ilvars, Tropé, Claes G, Micci, Francesca, ...

Abstract Background The epigenetics of ovarian carcinogenesis remains poorly described. We have in the present study investigated the promoter methylation status of 13 genes in primary ovarian...

TP53mutation status and gene expression profiles are powerful prognostic markers of breast cancer (2007)

Langerød, Anita, Zhao, Hongjuan, Borgan, Ørnulf, Nesland, Jahn M, Bukholm, Ida RK, Ikdahl, Tone, ...

Abstract Introduction Gene expression profiling of breast carcinomas has increased our understanding of the heterogeneous biology of this disease and promises to impact clinical care. The aim of this...

Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses (2007)

Kleivi, Kristine, Lind, Guro E, Diep, Chieu B, Meling, Gunn I, Brandal, Lin T, Nesland, Jahn M, ...

Abstract Background Despite the fact that metastases are the leading cause of colorectal cancer deaths, little is known about the underlying molecular changes in these advanced disease stages. Few...

Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situhybridization analysis (2005)

Reis-Filho, Jorge S, Milanezi, Fernanda, Carvalho, Silvia, Simpson, Pete T, Steele, Dawn, Savage, Kay, ...

Abstract Introduction Metaplastic breast carcinomas constitute a heterogeneous group of neoplasms, accounting for less than 1% of all invasive mammary carcinomas. Approximately 70–80% of...

TP53 mutations in ovarian carcinomas from sporadic cases and carriers of two distinct BRCA1founder mutations; relation to age at diagnosis and survival (2005)

Kringen, Pedro, Wang, Yun, Dumeaux, Vanessa, Nesland, Jahn M, Kristensen, Gunnar, Borresen-Dale, Anne-Lise, ...

Abstract Background Ovarian carcinomas from 30 BRCA1 germ-line carriers of two distinct high penetrant founder mutations, 20 carrying the 1675delA and 10 the 1135insA, and 100 sporadic cases were...

Variation in gene expression patterns in effusions and primary tumors from serous ovarian cancer patients (2005)

Schaner, Marci E, Davidson, Ben, Skrede, Martina, Reich, Reuven, Flørenes, Vivi, Risberg, Björn, ...

Abstract Background While numerous studies have characterized primary ovarian tumors, little information is available regarding expression patterns of metastatic sites of this cancer. To define sets...

Genome characteristics of primary carcinomas, local recurrences, carcinomatoses, and liver metastases from colorectal cancer patients (2004)

Diep, Chieu B, Teixeira, Manuel R, Thorstensen, Lin, Wiig, Johan N, Eknæs, Mette, Nesland, Jahn M, ...

Abstract Background Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths in the Western world, and despite the fact that metastases are usually the ultimate cause of...

Frameshift-mutation-derived peptides as tumor-specific antigens in inherited and spontaneous colorectal cancer

Sæterdal, Ingvil, Bjørheim, Jens, Lislerud, Kari, Gjertsen, Marianne K., Bukholm, Ida K., Olsen, Ole Christian, ...

The functional role and specificity of tumor infiltrating lymphocytes (TIL) is generally not well characterized. Prominent lymphocyte infiltration is the hallmark of the most common form of...

Different Gene Expression Patterns in Invasive Lobular and Ductal Carcinomas of the Breast

Zhao, Hongjuan, Langerød, Anita, Ji, Youngran, Nowels, Kent W., Nesland, Jahn M., Tibshirani, Rob, ...

Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) are the two major histological types of breast cancer worldwide. Whereas IDC incidence has remained stable, ILC is the most...

Candidate Genes for Testicular Cancer Evaluated by In Situ Protein Expression Analyses on Tissue Microarrays1

Skotheim, Rolf I, Abeler, Vera M, Nesland, Jahn M, Fosså, Sophie D, Holm, Ruth, Wagner, Urs, ...

By the use of high-throughput molecular technologies, the number of genes and proteins potentially relevant to testicular germ cell tumor (TGCT) and other diseases will increase rapidly. In a recent...

Evaluation of 1p Losses in Primary Carcinomas, Local Recurrences and Peripheral Metastases from Colorectal Cancer Patients1

Thorstensen, Lin, Qvist, Hanne, Heim, Sverre, Liefers, Gerrit-Jan, Nesland, Jahn M, Giercksky, Karl-Erik, ...

Cytogenetic and molecular genetic analyses of colorectal adenomas and carcinomas have shown that loss of the distal part of chromosome arm 1p is common, particularly in tumors of the left colon....

Frameshift-mutation-derived peptides as tumor-specific antigens in inherited and spontaneous colorectal cancer

Sæterdal, Ingvil, Bjørheim, Jens, Lislerud, Kari, Gjertsen, Marianne K., Bukholm, Ida K., Olsen, Ole Christian, ...

The functional role and specificity of tumor infiltrating lymphocytes (TIL) is generally not well characterized. Prominent lymphocyte infiltration is the hallmark of the most common form of...

Different Gene Expression Patterns in Invasive Lobular and Ductal Carcinomas of the Breast

Zhao, Hongjuan, Langerød, Anita, Ji, Youngran, Nowels, Kent W., Nesland, Jahn M., Tibshirani, Rob, ...

Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) are the two major histological types of breast cancer worldwide. Whereas IDC incidence has remained stable, ILC is the most...

Candidate Genes for Testicular Cancer Evaluated by In Situ Protein Expression Analyses on Tissue Microarrays1

Skotheim, Rolf I, Abeler, Vera M, Nesland, Jahn M, Fosså, Sophie D, Holm, Ruth, Wagner, Urs, ...

By the use of high-throughput molecular technologies, the number of genes and proteins potentially relevant to testicular germ cell tumor (TGCT) and other diseases will increase rapidly. In a recent...

Evaluation of 1p Losses in Primary Carcinomas, Local Recurrences and Peripheral Metastases from Colorectal Cancer Patients1

Thorstensen, Lin, Qvist, Hanne, Heim, Sverre, Liefers, Gerrit-Jan, Nesland, Jahn M, Giercksky, Karl-Erik, ...

Cytogenetic and molecular genetic analyses of colorectal adenomas and carcinomas have shown that loss of the distal part of chromosome arm 1p is common, particularly in tumors of the left colon....

Protein Expression of the Cell-Cycle Inhibitor p27Kip1 in Malignant Melanoma : Inverse Correlation with Disease-Free Survival

Flørenes, Vivi Ann, Mælandsmo, Gunhild M., Kerbel, Robert S., Slingerland, Joyce M., Nesland, Jahn M., Holm, Ruth

In the present study we analyzed, by immunohistochemistry, a panel of human melanomas for protein expression of the cyclin-dependent kinase (cdk) inhibitor p27Kip1 and evaluated whether deregulated...

NKX3.1 Expression Is Lost in Testicular Germ Cell Tumors

Skotheim, Rolf I., Korkmaz, Kemal S., Klokk, Tove I., Abeler, Vera M., Korkmaz, Ceren G., Nesland, Jahn M., ...

NKX3.1 is a homeobox gene which exhibits prostate and testis specific expression. Loss of NKX3.1 expression has been implicated in prostate development and tumorigenesis, but the role of NKX3.1 in...