Jaeman Byun

Bromination of deoxycytidine by eosinophil peroxidase: A mechanism for mutagenesis by oxidative damage of nucleotide precursors

Henderson, Jeffrey P., Byun, Jaeman, Williams, Michelle V., McCormick, Michael L., Parks, William C., Ridnour, Lisa A., ...

Oxidants generated by eosinophils during chronic inflammation may lead to mutagenesis in adjacent epithelial cells. Eosinophil peroxidase, a heme enzyme released by eosinophils, generates hypobromous...

Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis

Gaut, Joseph P., Yeh, George C., Tran, Hung Duy, Byun, Jaeman, Henderson, Jeffrey P., Richter, Grace M., ...

The myeloperoxidase system of neutrophils uses hydrogen peroxide and chloride to generate hypochlorous acid, a potent bactericidal oxidant in vitro. In a mouse model of polymicrobial sepsis, we...

Myeloperoxidase produces nitrating oxidants in vivo

Gaut, Joseph P., Byun, Jaeman, Tran, Hung D., Lauber, Wendy M., Carroll, James A., Hotchkiss, Richard S., ...

Despite intense interest in pathways that generate reactive nitrogen species, the physiologically relevant mechanisms for inflammatory tissue injury remain poorly understood. One possible mediator is...

The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport

Bergt, Constanze, Pennathur, Subramaniam, Fu, Xiaoyun, Byun, Jaeman, O'Brien, Kevin, McDonald, Thomas O., ...

Although oxidatively damaged lipoproteins are implicated in vascular injury, there is little information regarding the role of high-density lipoprotein (HDL) oxidation in atherogenesis. One potential...

Bromination of deoxycytidine by eosinophil peroxidase: A mechanism for mutagenesis by oxidative damage of nucleotide precursors

Henderson, Jeffrey P., Byun, Jaeman, Williams, Michelle V., McCormick, Michael L., Parks, William C., Ridnour, Lisa A., ...

Oxidants generated by eosinophils during chronic inflammation may lead to mutagenesis in adjacent epithelial cells. Eosinophil peroxidase, a heme enzyme released by eosinophils, generates hypobromous...

Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis

Gaut, Joseph P., Yeh, George C., Tran, Hung Duy, Byun, Jaeman, Henderson, Jeffrey P., Richter, Grace M., ...

The myeloperoxidase system of neutrophils uses hydrogen peroxide and chloride to generate hypochlorous acid, a potent bactericidal oxidant in vitro. In a mouse model of polymicrobial sepsis, we...

Myeloperoxidase produces nitrating oxidants in vivo

Gaut, Joseph P., Byun, Jaeman, Tran, Hung D., Lauber, Wendy M., Carroll, James A., Hotchkiss, Richard S., ...

Despite intense interest in pathways that generate reactive nitrogen species, the physiologically relevant mechanisms for inflammatory tissue injury remain poorly understood. One possible mediator is...

The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport

Bergt, Constanze, Pennathur, Subramaniam, Fu, Xiaoyun, Byun, Jaeman, O'Brien, Kevin, McDonald, Thomas O., ...

Although oxidatively damaged lipoproteins are implicated in vascular injury, there is little information regarding the role of high-density lipoprotein (HDL) oxidation in atherogenesis. One potential...

Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL

Vaisar, Tomas, Pennathur, Subramaniam, Green, Pattie S., Gharib, Sina A., Hoofnagle, Andrew N., Cheung, Marian C., ...

HDL lowers the risk for atherosclerotic cardiovascular disease by promoting cholesterol efflux from macrophage foam cells. However, other antiatherosclerotic properties of HDL are poorly understood....